Phytochemical analysis and in vitro and in vivo evaluation of biological activities of artichoke (Cynara scolymus L.) floral stems: Towards the valorization of food by-products

Mejri, Faiza; Baâti, Tarek; Martins, Alice; Selmi, Slimen; Serralheiro, Maria Luísa; Falé, Pedro L.; Rauter, Amélia P.; Casabianca, Hervé; Hosni, Karim

doi:10.1016/j.foodchem.2020.127506

Cited by 24 publications

(16 citation statements)

References 37 publications

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“…Flower and bracts contain Luteo-lin-7-O-glucoside (cynaroside), 3-O-Caffeoylquinic acid (Neo Chlorogenic acid). 5-O-Caffeoylquinic acid (Chlorogenic acid), Luteolin 7-O-malonylglucoside, 1,5-di-O-Caffeoylquinic acid, 3,5-Di-O-caffeoylquinic Acid, also reported in [ 41 , 53 , 54 ] Chlorogenic Acid, Luteolin, luteolin-7- O -rutinoside and Apigenin are existing in the three parts with considerable difference in concentration as reported in [ 41 , 45 , 56 ], and this finding agrees with our study. These polyphenols exhibited cytotoxic effects and apoptosis-induction activity that help in the treatment of prostate and lung cancer.…”

Section: Discussionmentioning

confidence: 94%

Comparative Estimation of the Cytotoxic Activity of Different Parts of Cynara scolymus L.: Crude Extracts versus Green Synthesized Silver Nanoparticles with Apoptotic Investigation

et al. 2022

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Different parts of Cynara scolymus L. and their green synthesized eco-friendly silver nanoparticles (AgNPs) were screened for their cytotoxicity and apoptotic activity. Results showed that flower extract AgNPs exhibited more potent cytotoxicity compared to the normal form against PC-3 and A549 cell lines with IC50 values of 2.47 μg/mL and 1.35 μg/mL, respectively. The results were compared to doxorubicin (IC50 = 5.13 and 6.19 μg/mL, respectively). For apoptosis-induction, AgNPs prepared from the flower extract induced cell death by apoptosis by 41.34-fold change and induced necrotic cell death by 10.2-fold. Additionally, they induced total prostate apoptotic cell death by a 16.18-fold change, and it slightly induced necrotic cell death by 2.7-fold. Hence, green synthesized flower extract AgNPs exhibited cytotoxicity in A549 and PC-3 through apoptosis-induction in both cells. Consequently, synthesized AgNPs were further tested for apoptosis and increased gene and protein expression of pro-apoptotic markers while decreasing expression of anti-apoptotic genes. As a result, this formula may serve as a promising source for anti-cancer candidates. Finally, liquid chromatography combined with electrospray mass spectrometry (LC-ESI-MS) analysis was assessed to identify the common bioactive metabolites in crude extracts of stem, flower, and bract.

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Section: Discussionmentioning

confidence: 94%

Comparative Estimation of the Cytotoxic Activity of Different Parts of Cynara scolymus L.: Crude Extracts versus Green Synthesized Silver Nanoparticles with Apoptotic Investigation

et al. 2022

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“…The administration of the extract resulted in a decrease in the serum profile levels and blood glucose. [184] var. altilis DC.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Silva

Jacinto

Coutinho

2022

Foods

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Cardoon (Cynara cardunculus L.) is a Mediterranean plant and member of the Asteraceae family that includes three botanical taxa, the wild perennial cardoon (C. cardunculus L. var. sylvestris (Lamk) Fiori), globe artichoke (C. cardunculus L. var. scolymus L. Fiori), and domesticated cardoon (C. cardunculus L. var. altilis DC.). Cardoon has been widely used in the Mediterranean diet and folk medicine since ancient times. Today, cardoon is recognized as a plant with great industrial potential and is considered as a functional food, with important nutritional value, being an interesting source of bioactive compounds, such as phenolics, minerals, inulin, fiber, and sesquiterpene lactones. These bioactive compounds have been vastly described in the literature, exhibiting a wide range of beneficial effects, such as antimicrobial, anti-inflammatory, anticancer, antioxidant, lipid-lowering, cytotoxic, antidiabetic, antihemorrhoidal, cardiotonic, and choleretic activity. In this review, an overview of the cardoon nutritional and phytochemical composition, as well as its biological potential, is provided, highlighting the main therapeutic effects of the different parts of the cardoon plant on metabolic disorders, specifically associated with hepatoprotective, hypolipidemic, and antidiabetic activity.

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“…O aumento na resistência à insulina diminui a translocação de GLUT, diminui captação e absorção de glicose (Al-Ishaq et al, 2019). Segundo Mejri et al (2020), a apigenina presente na alcachofra são benéficas na redução glicêmica, protegendo as células beta-pancreáticas de danos oxidativos, aumenta a secreção de insulina e possibilita maior captação de glicose pelos transportadores (GLUT).…”

Section: Transporte De Glicoseunclassified

“…No entanto, o uso de plantas medicinais já vem sendo usado há bastante tempo, a alcachofra é uma planta importante estudada por diversos trabalhos, sendo abordada devido à capacidade de atuarem no diabetes mellitus. Uma das ações da alcachofra é na proteção das células β pancreáticas foi demonstrado que os ácidos cafeoilquínicos presentes na alcachofra, como o ácido feoilquínico 5-O-caf; Ácido 3,4-dicafeoilquínico; Ácido 3,5-dicafeoilquínico; Ácido 4,5-dicafeoilquínico; e seus derivados de metila e etila são os principais responsáveis pela proteção das células β pancreáticas, estimulação da secreção de insulina e inibição de α-glicosidase (Mejri et al, 2020).…”

Section: Secreção De Insulinaunclassified

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Mecanismo de ação da alcachofra (Cynara Scolymus L.) no controle glicêmico: Uma revisão sistemática

Oliveira

Domingueti

Santos

et al. 2021

RSD

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O diabetes mellitus gera um grave problema ao sistema de saúde e aos indivíduos, sendo caracterizado por um distúrbio crônico, que afeta o metabolismo de carboidratos, gorduras e proteínas. O presente estudo tem por objetivo realizar uma revisão de literatura demonstrando os mecanismos de ação da alcachofra no controle glicêmico. Foi efetuada uma busca eletrônica noScielo, Pubmed,Science direct e Google Scholar, comparando as diferentes informações encontradas nestas plataformas, listando os mecanismos de ação da alcachofra no controle glicêmico no diabetes mellitus. Foram levantados 63 artigos científicos na língua portuguesa, inglesa e espanhola, dos quais 17,5% abordaram sobre a alcachofra sua composição, conteúdos fenólicos e efeitos anti-hiperglicêmicos, 13 % descrevem sobre os polifenóis, flavonoides e sua ação anti hiperglicêmica, 16 % relata sobre a regulação da α-glicosidase, 6% aborda sobre o transporte de glicose via GLUT; 6% sobre a secreção de insulina pelas células beta pancreáticas, 13% relata a regulação do metabolismo de glicose hepática, 11 % relata a eliminação renal de glicose, 9,5% sobre o diabetes e suas complicações e 8% aborda outras plantas e compostos naturais com ação semelhante a alcachofra. De acordo com resultados a possível ação da alcachofra e seus metabólitos especiais está na inibição da alfa-glicosidase, e acrescentar sua importante ação na redução dos radicais livre, redução do glucagon, manutenção hepática do metabolismo glicêmico, proteção das células beta-pancreática, aumento nos níveis de insulina, e captação de glicose nos tecidos, sendo importante fatores na homeostase glicêmica. Por outro lado, a utilização de flavonoides é um dos alvos mais utilizados pela literatura no controle glicêmico a médio e longo prazo. Com a presente revisão é possível concluir que todas as vias mencionadas acima, torna-se algo promissor na busca por tratamento complementar do controle glicêmico de indivíduos portadores do diabetes mellitus.

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Phytochemical analysis and in vitro and in vivo evaluation of biological activities of artichoke (Cynara scolymus L.) floral stems: Towards the valorization of food by-products

Cited by 24 publications

References 37 publications

Comparative Estimation of the Cytotoxic Activity of Different Parts of Cynara scolymus L.: Crude Extracts versus Green Synthesized Silver Nanoparticles with Apoptotic Investigation

Comparative Estimation of the Cytotoxic Activity of Different Parts of Cynara scolymus L.: Crude Extracts versus Green Synthesized Silver Nanoparticles with Apoptotic Investigation

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Mecanismo de ação da alcachofra (Cynara Scolymus L.) no controle glicêmico: Uma revisão sistemática

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