Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L. for in vitro antioxidant activities

Senguttuvan, Jamuna; Paulsamy, S.; Krishnamoorthy, Karthika

doi:10.12980/apjtb.4.2014c1030

Cited by 256 publications

(199 citation statements)

References 25 publications

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“…It also has antifungal and antimicrobial activity (17 (19,20). Juglone also showed antifungal activity comparable to that of other medications such as griseofulvin, clotrimazole, and tolnaftate (19). Furthermore, the antifungal activity of juglone has been demonstrated in other studies (21, 22).…”

Section: Introductionmentioning

confidence: 84%

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Comparison of the Effects of Juglans nigra Green Husk and Clotrimazole on Candida albicans in Rats

Abedi

Honarmandpour

Fatahinia

et al. 2017

Jundishapur J Microbiol

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Background: Black walnut (Juglans nigra) is known to have antimicrobial and antifungal effects in vitro. Objectives: This study aimed to compare the effects of extracts derived from green-husked walnut with clotrimazole against Candida albicans in female rats. Methods: In this study, 35 female Wistar rats were randomly assigned to 5 groups. A total of 4 groups of rats were infected vaginally with C. albicans and 1 group was not infected (negative control). The 4 infected groups received the following treatments: 2 groups received vaginal creams containing 2% or 4% of J. nigra extracts, respectively, 1 group received 1% clotrimazole, and 1 group did not receive any treatment (positive control). All rats received treatments for 2 weeks.

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Section: Introductionmentioning

confidence: 84%

“…Juglone can also tighten the skin, relieve irritation (15), and improve cardiovascular status (16). It also has antifungal and antimicrobial activity (17 (19,20). Juglone also showed antifungal activity comparable to that of other medications such as griseofulvin, clotrimazole, and tolnaftate (19).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effects of Juglans nigra Green Husk and Clotrimazole on Candida albicans in Rats

Abedi

Honarmandpour

Fatahinia

et al. 2017

Jundishapur J Microbiol

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“…The leaves were then grinded by denotes of motor pistal followed by filtration so as to abstract the solid waste. Solvent extraction [48][49][50] of leaves was then done using 30% ethanol and water. The extract was then stored at 4°C for further use [51][52][53].…”

Section: Collection Of Leaves and Extract Preparationmentioning

confidence: 99%

Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

Chauhan

Shrivastava

Prasad

et al. 2018

Asian J Pharm Clin Res

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Methods: Extraction of Syzygium cumini was done and was used for silver nanoparticle synthesis. The synthesized nanoparticles were characterized by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy, which confirms the availability of nanosilver particles with marginally spherical morphology. The particles were then carried forward for treating impaired diabetic wounds in Wistar rat models. Regular photography was done and wound healing parameters were monitored throughout the study along with analyzing other parameters such as biochemical, hematological, and histological parameters. Results:The study showed that the sizes of the synthesized nanoparticles are below 100 nm. The results obtained from in vivo studies showed efficient wound healing potential of silver nanoparticles as compared to pre-existing drug povidone-iodine, i.e., the percentage reduction in wound area after therapy is 96.09% in case of biosynthesized silver nanoparticle-treated group, 97.7% reduction in chemically synthesized silver nanoparticle-treated group, 64.28% reduction in case of pre-existing drug povidone-iodine-treated group, 37.5% reduction in case of diabetic control group (diabetic), and 97.5% reduction in normal control group (non-diabetic). Results showed that biosynthesized silver nanoparticles showed less toxicity with respect to liver and kidney functions. Skin histology results showed increased sign of wound healing in biosynthesized silver nanoparticles. Hematology results showed no such variation. Conclusion:The study will help to synthesize new economically viable potential biosynthesized nanoparticles along with providing the approach to develop the medication at nanoscale level.

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“…Then the seeds were crushed manually to a powder with a mortar and pestle at room temperature in the absence of sunlight. Powered material was subjected to successive extraction by maceration in petroleum ether, chloroform, ethanol and water (increasing order of their polarity).Extract was then filtered and evaporated to obtain concentrate [37].…”

Section: In Vitro Approach 221 Plant Materials and Extract Preparationmentioning

confidence: 99%

Strategies in the Design of Antidiabetic Drugs from Terminalia Chebula Retz. Using in silico and in vitro Approach

Bansode

Salalkar

2016

Preprint

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Diabetes mellitus is the fifth deadliest disease in the developing countries. Even with all the research and new drugs available, combating diabetes is still challenging. There are successes in finding new cost effective drugs without side effects, even if not perfect. In our investigation we studied binding mechanism of secondary metabolite of T. chebula in silico. It was observed that three compounds out of 16 have a higher binding affinity for the target proteins. Ellagic acid showed highest binding affinity with alpha amylase, beta glucosidase and alpha glucosidase with lesser binding energies -4.5kcal/mol, -5.36kcal/mol and -4.48kcal/mol respectively. Arjungenin has lesser binding energy of 4.77 kcal/mol with glucokinase while luteoline has binding energy of -7.25kcal/mol for enzyme glycogen synthase kinase. These entire compounds interacted with non-covalent interaction. Petroleum ether extract showed the significant alpha amylase inhibitory activity i.e. 51.22% as compared to standard drug (65.99%).TLC analysis revealed the presence of total 9 compounds in different plant extracts one of them might be a lead compound which could be further exploited for the development of novel safer and potent antidiabetic drug.

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Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L. for in vitro antioxidant activities

Abstract: From this study, it can be concluded that the species is effective in scavenging free radicals and has the potential to be a powerful antioxidant.

Cited by 256 publications

References 25 publications

Comparison of the Effects of Juglans nigra Green Husk and Clotrimazole on Candida albicans in Rats

Comparison of the Effects of Juglans nigra Green Husk and Clotrimazole on Candida albicans in Rats

Effect of Silver Nanoparticle-Mediated Wound Therapy on Biochemical, Hematological, and Histological Parameters

Strategies in the Design of Antidiabetic Drugs from <em>Terminalia Chebula Retz.</em> Using <em>in silico</em> and <em>in vitro</em> Approach

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