Phytochemical Analysis and Dermo-Cosmetic Evaluation of Cymbidium Sw. cultivation by-products. Circular economy in North Aegean island of Samos.

Axiotis, Evangelos; Angelis, Apostolis; Antoniadi, Lemonia; Petrakis, Eleftherios A.; Skaltsounis, LA

doi:10.1055/s-0041-1736904

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All four isolated compounds (1-4) from V. bensonii have been reported to be isolated from a variety of sources [15][16][17][18][19][20][21][22][23][24][25][26][27][28], but the information regarding their roles in anticancer activities, especially for antimetastatic roles, is still limited. To develop secondary malignant sites, cancer cells migrate and invade into vascular and lymphatic systems [11,12,14].…”

Section: Discussionmentioning

confidence: 99%

“…Li et al [19] also found this compound in Gastrodia elata, an herbal composition of a Chinese "Tianshu" formula for migraine therapy. The compound possesses diverse bioactivities, including anticancer [18] and anti-collagenase properties [20]. The anticancer activity of this phytochemical was assessed with human small cell lung cancer (NCI-H187) cells, and its IC50 value was 3.73 μM, which was greater and weaker than that of the positive controls, ellipticine (17.09 μM) and doxorubicin (0.24 μM), respectively [18].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Phytochemicals from Vanda bensonii and Their Bioactivities to Inhibit Growth and Metastasis of Non-Small Cell Lung Cancer Cells

et al. 2022

View full text Add to dashboard Cite

The most prevalent lung cancer is non-small cell lung cancer (NSCLC). This lung cancer type often develops other organ-specific metastases that are critical burdens in the treatment process. Orchid species in the genus Vanda have shown their potential in folkloric medication of diverse diseases but not all its species have been investigated, and little is known about their anticancer activities against NSCLC. Here, we firstly profiled the specialized metabolites of Vanda bensonii and examined their capability to inhibit growth and metastasis of NSCLC using NCI-H460 cells as a study model. Four phytochemicals, including phloretic acid methyl ester (1), cymbinodin-A (2), ephemeranthoquinone B (3), and protocatechuic acid (4), were isolated from the whole plant methanolic extract of V. bensonii. The most distinguished cytotoxic effect on NCI-H460 cells was observed in the treatments with crude methanolic extract and compound 2 with the half maximal inhibitory concentrations of 40.39 μg mL−1 and 50.82 μM, respectively. At non-cytotoxic doses (10 μg mL−1 or 10 μM), only compound 1 could significantly limit NCI-H460 cell proliferation when treated for 48 h, while others excluding compound 4 showed significant reduction in cell proliferation after treating for 72 h. Compound 1 also significantly decreased the migration rate of NCI-H460 cells examined through a wound-healing assay. Additionally, the crude extract and compound 1 strongly affected survival and growth of NCI-H460 cells under anchorage-independent conditions. Our findings proved that natural products from V. bensonii could be promising candidates for the future pharmacotherapy of NSCLC.

show abstract