Phythämagglutinin (PHA) und Serumproteine in der Lymphocytenkultur

Havemann, K.; Hm, Dosch; Bürger, S

doi:10.1007/bf02048091

Cited by 13 publications

(2 citation statements)

References 25 publications

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“…In recent years there have been reports indicating an association between a2-macroglobulin (a2M, MW 820 000) and the development and function of lymphocytes (McNeill, 1970;Havemann, Dosch, and Burger, 1970;Chase, 1972;Ford, Caspary, and Shenton, 1973). There are also indications that it is present on the surface of a subpopulation of lymphocytes (Sell, 1970;McCormick, Nelson, Tunstall, and James, 1973;James, Tunstall, Parker, and McCormick, 1974) and may be synthesized by peripheral blood lymphocytes (van Furth, Shuit, and Hijmans, 1966;Tunstall and James, 1974).…”

mentioning

confidence: 99%

Normal and pathological serum levels of alpha2-macroglobulins in men and mice.

Tunstall¹,

Merriman²,

Milne³

et al. 1975

J Clin Pathol

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The serum levels of alpha2-macroglobulin have been measured in normal men and mice and in a number of immunopathological conditions. Normal human concentrations are high in youth, reach their minimum in middle age, and gradually increase with old age. In all age groups the mean is higher in the female than in the male. Conversely, in normal mice the alpha2M level is low in youth, maximum in middle age, and shows a slight depression with old age, and the levels are frequently higher in males than in females; there are also strain variations. In human immunopathological conditions, there are some deviations from the normal alpha2M level but these are seen to be changes from the normal distribution of values around the mean, rather than significant elevation or depression of mean values. In some disease states studied there are differences between the sexes in the deviation from normal. "Abnormal" strains of mice had alpha2M levels within the range exhibited by "normal" mice but changes in the levels are seen in mice with various myelomas.

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mentioning

confidence: 99%

Normal and pathological serum levels of alpha2-macroglobulins in men and mice.

Tunstall¹,

Merriman²,

Milne³

et al. 1975

J Clin Pathol

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“…Die Wirkung von PHA auf Lymphozyten ist somit als ausserordentlich komplex anzusehen. Neben dem direkten Effekt auf den Lymphozyten [5,6,8] …”

Section: Diskussionunclassified

Untersuchungen zur wachstumsfördernden Wirkung von Antiproteasen auf Lymphozyten <i>in vitro</i>

Havemann¹,

Bürger²,

Dosch³

1971

Acta Haematol

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The influence of esterases and antiproteases on lymphocytes cultures has been investigated. Phytohaemagglutinin (PHA) and certain PHA fractions exhibited antiprotease activity. Some plant- and animal-antiproteases showed growth promoting activity in stimulated lymphocyte cultures, an effect which could be reduced considerably by incubation with trypsin. Cell homogenates and cell-free supernatants from stimulated lymphocyte cultures contained esterase activity. There is some evidence that these esterases are bound to antiproteases, a process which might be necessary for optimal lymphocyte growth.

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Der Einfluß von Serumfraktionen und von Polynucleotiden (Poly I:C) auf die Knochenmarksregeneration subletal bestrahlter Ratten

Hedrich

Havemann

et al. 1972

Verhandlungen Der Deutschen Gesellschaft Für Innere Medizin

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Phythämagglutinin (PHA) und Serumproteine in der Lymphocytenkultur

Cited by 13 publications

References 25 publications

Normal and pathological serum levels of alpha2-macroglobulins in men and mice.

Normal and pathological serum levels of alpha2-macroglobulins in men and mice.

Untersuchungen zur wachstumsfördernden Wirkung von Antiproteasen auf Lymphozyten <i>in vitro</i>

Der Einfluß von Serumfraktionen und von Polynucleotiden (Poly I:C) auf die Knochenmarksregeneration subletal bestrahlter Ratten

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