Physiopathology and Management of Uterine Fibroids

Tochie, Joël Noutakdie; Badjang, Gaelle Therese; Ayissi, Gregory; Dohbit, Julius Sama

doi:10.5772/intechopen.94162

Cited by 5 publications

(3 citation statements)

References 27 publications

(27 reference statements)

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“…Haji Adam Malik General Hospital is a class A general hospital and serves as a referral center for the North Sumatra region and its surroundings, along with the development of the medical profession because there are more and more obstetrics and gynecology specialists in the area who play a role in early diagnosis of cases of both AUB and malignancy, so that referrals are made to more competent health facilities when screening patients in regional hospitals. 13 17 in Cameroon showed similar results and found that the majority of leiomyoma locations were submucosal (89.4%).…”

Section: Resultssupporting

confidence: 58%

Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia

Nainggolan

Rusda

Faradina

et al. 2023

MOG

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HIGHLIGHTS Leiomyoma is still the most common case in women aged 41–50 years. Women who have an obese BMI are the main risk factor for abnormal uterine bleeding, so it is urged for women to maintain an ideal weight because it can be bad for health. ABSTRACT Objective: This study identified the incidence of Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, Indonesia, in 2020-2021. Materials and Methods: This was a descriptive study with a cross-sectional design. Sampling was taken using total sampling and using retrospective data in the form of medical records with a diagnosis of AUB at Haji Adam Malik General Hospital Medan in 2020–2021. Results: There were 197 cases of AUB, with the highest distribution in the age group of 41–50 years with 84 people (42.6%). The most cases of AUB with an obese BMI were 91 people (46.2%), married status as many as 176 people (89.3%), had the last education level of senior high school as many as 99 people (50.3%), 144 people (73.1%) got their first menstruation when they were >12 years old, 80 people (40.6%) had multiparity, 90 people (45.7%) received medical therapy. Based on the PALM-COEIN classification, the most AUB cases were AUB-L with 99 people (50.3%). Based on the classification of AUB-L locations, most locations were submucosa with 38.6%. Conclusion: AUB-L cases were still the most common cases at Haji Adam Malik General Hospital, Medan, Indonesia, in 2020–2021.

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Section: Resultssupporting

confidence: 58%

Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia

Nainggolan

Rusda

Faradina

et al. 2023

MOG

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“…Л ейоміому матки (ЛМ) на сьогодні розглядають як доброякісну істинну пухлину матки, що не просто розвивається в міометрії, а виникає з гладком'язової тканини міометрію незалежно від наявності або відсутності фібропластичного компонента у вузлах пухлини і рівня гормонозалежності. ЛМ є моноклональною пухлиною, тобто зростання її походить з од-нієї первинної мутантної клітини, яка набуває здатності нерегульованого поділу [24]. Поширеність ЛМ під час вагітності коливається в межах від 10,7% до 16,7% [4,16].…”

Section: вступunclassified

Prevention of complications during pregnancy and childbirth in women with uterine leiomyoma

Golyanovskiy,

Supruniuk

2024

UJHW

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Purpose - to evaluate the clinical effectiveness of the proposed preventive and therapeutic complex using modern drugs and organ-preserving methods of surgical treatment in pregnant women with uterine leiomyoma FIGO (International Federation of Gynecology and Obstetrics) type 3-6. Materials and methods. This prospective study was conducted with a comprehensive examination, selection of optimal tactics for pregnancy management and delivery in 70 pregnant women with uterine leiomyoma using the complex developed by us (main group), 41 pregnant women with uterine leiomyoma with standard pregnancy management (comparison group) and 50 pregnant women without uterine leiomyomas in the II-III trimesters of pregnancy and after childbirth at 4 clinical bases of the Department of Obstetrics and Gynecology No. 1 of the Shupyk National Healthcare University of Ukraine for 3 years - 2020-2023. Results. 70 pregnant women of the main group, who used the treatment and prevention complex developed by us, had significantly lower rates of iron deficiency anemia, the frequency of the threat of premature birth, fetal distress, and hypotonic labor compared to the comparison group and approached the rates of the control group (p<0.05). A 1.8-fold decrease in the risk of premature birth among women in the main group was also noted, as well as a 1.3-fold decrease in the cesarean section rate. PPH volume during vaginal delivery and cesarean section in the main group was significantly lower compared to the comparison group (p<0.01) and had no statistical difference with the control group (p>0.05). Conclusions. Pregnant women with uterine leiomyoma have an increased risk of iron-deficiency anemia, the threat of premature birth, weakness in labor, fetal distress, cesarean section, and PPH development. The treatment and prevention complex proposed by us and the optimal technique for performing cesarean sections allowed not only to reduce the frequency of complications during pregnancy and childbirth, but also to reduce the rate of PPH and reduce the indicators of maternal morbidity. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

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“…Cytogenetic studies have shown that approximately 40%–50% of UF harbor chromosomal abnormalities and linked to changes in a number of genes, including MED12, HMGA2, COL4A5/COL4A6, and FH genes ( McGuire et al, 2012 ; Segars et al, 2014 ). Studies have demonstrated that from total genetic aberration, about 70%–80% of uterine leiomyoma’s shown site-specific somatic mutation on mediator complex subunit 12 ( MED12 ) genes in different populations, including Finnish (Caucasian), northern United States regions, and South African women ( Mittal et al, 2015 ; Noutakdie Tochie et al, 2021 ). These studies suggest the need to have ethnic or population specific genetic data to gain insight into the disease etiology.…”

Section: Introductionmentioning

confidence: 99%

Gene variants polymorphisms and uterine leiomyoma: an updated review

Upadhyay,

Dubey

2024

Front. Genet.

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Uterine leiomyoma, commonly referred to as fibroids, is a benign tumor that develops in the muscular wall of the uterus. These growths are non-cancerous and can vary in size, ranging from tiny nodules to larger masses. Uterine leiomyomas often occur during a woman’s reproductive years and can lead to symptoms such as heavy menstrual bleeding, pelvic pain, and pressure on nearby organs. While the exact cause is not fully understood, hormonal factors, particularly estrogen and progesterone, are believed to play a role in their development. The exploration of connections between genetic variants and uterine leiomyoma has captivated scientific attention for numerous years. The results from investigations remain a subject of intrigue within the scientific community. To date, the findings regarding the relationships between single nucleotide polymorphisms (SNPs) and uterine leiomyoma have exhibited some inconsistencies. However, amidst these inconsistencies, several promising outcomes have emerged that hold the potential to shape future research endeavors. These promising leads could pave the way for the development of innovative targeted therapies and novel prognostic biomarkers. This review specifically centers on accentuating the existing literature data concerning genetic variants that have been explored for their potential connections to uterine leiomyoma. Additionally, it underscores the prospects of employing genetic variations as diagnostic and prognostic biomarkers for individuals diagnosed with uterine leiomyoma.

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Physiopathology and Management of Uterine Fibroids

Cited by 5 publications

References 27 publications

Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia

Abnormal Uterine Bleeding (AUB) at Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia

Prevention of complications during pregnancy and childbirth in women with uterine leiomyoma

Gene variants polymorphisms and uterine leiomyoma: an updated review

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