Physiopathologie et tableaux cliniques des rhabdomyolyses

Guis, Sandrine; Mattei, Jean‐Pierre; Cozzone, Patrick J.; Bendahan, David

doi:10.1016/j.rhum.2004.04.015

Cited by 7 publications

(10 citation statements)

References 59 publications

(58 reference statements)

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“…A positive diagnosis requires raised CK levels, in correlating clinical circumstances 1. Rhabdomyolysis is defined when CK are five times higher than normal values (1000 UI/L) and severe rhabdomyolysis when CK values are above 5000 UI/L 2. The different aetiologies can be classified by traumatic causes consisting of decreased energetic supplies and increased pressure in muscles and non-traumatic causes like toxicity 1.…”

Section: Discussionmentioning

confidence: 99%

“…The different aetiologies can be classified by traumatic causes consisting of decreased energetic supplies and increased pressure in muscles and non-traumatic causes like toxicity 1. In non-traumatic causes, alcohol and drugs (antipsychotics, statins) are responsible for 80% of cases in the adult population 2. Strength training, infectious syndromes and metabolic disorders are also often found in patients with rhabdomyolysis,1 and 50% of cases have multiple aetiologies 3.…”

Section: Discussionmentioning

confidence: 99%

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Severe rhabdomyolysis induced by quetiapine and mirtazapine in a French military soldier

et al. 2018

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Rhabdomyolysis is a potential complication of psychotropic drugs use and may potentially lead to life-threatening complications, such as an acute renal failure. We describe the case of a 40-year-old military soldier suffering from post-traumatic stress disorder was admitted for an adaptation of his treatment. Mirtazapine was introduced and quetiapine increased. Two days later, the patient presented with severe rhabdomyolysis syndrome. Mirtazapine administration was paused and intravenous hydration commenced. Shortly after the creatine kinase levels decreased enabling mirtazapine to be reintroduced without complication. It is our opinion that 5-hydroxytryptamine 2a serotonergic receptors inhibition (related to mirtazapine and quetiapine) associated with muscle training was responsible for inducing rhabdomyolysis. This must be kept in mind when psychotropic medications are adjusted, especially in an athletic population such as military.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Severe rhabdomyolysis induced by quetiapine and mirtazapine in a French military soldier

et al. 2018

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“…However, haemolysis and muscle damage will result in hyperkalaemia and will affect normal neuronal conduction in the heart, leading to cardiac fibrillation and ultimately death. This fibrillation will be exacerbated if high circulating adrenalin from the adrenals is present (Harthoorn, 1976; Guis et al , 2005).…”

Section: Capture Myopathy Presentation In Animalsmentioning

confidence: 99%

“…This capture shock syndrome has a similar underlying pathophysiology to neurological vasogenic shock. The main distinguishing factor between the two is the presence of rhabdomyolysis in capture shock syndrome and the resultant myoglobin protein detected in the renal tubules, which is the main cause of the kidney injury (Vanholder et al , 2000; Guis et al , 2005; Oberem and Oberem, 2011). Distinguishing between these two conditions does not make them mutually exclusive.…”

Section: Capture Myopathy Presentation In Animalsmentioning

confidence: 99%

“…Although not yet understood, opioids are thought to cause hyperthermia through sympathetic stimulation, which increases metabolism and resultant heat production (Meyer, 2009; Atkinson et al , 2012). Furthermore, many of the drugs that are used in wildlife like ketamine, haloperidol, diazepam, naltrexone and succinyl choline are known to induce rhabdomyolysis directly in humans (Guis et al , 2005).…”

Section: Prevention Of Capture Myopathymentioning

confidence: 99%

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Conserving wildlife in a changing world: Understanding capture myopathy—a malignant outcome of stress during capture and translocation

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Meyer

Steyl

et al. 2019

Conservation Physiology

136

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The number of species that merit conservation interventions is increasing daily with ongoing habitat destruction, increased fragmentation and loss of population connectivity. Desertification and climate change reduce suitable conservation areas. Physiological stress is an inevitable part of the capture and translocation process of wild animals. Globally, capture myopathy—a malignant outcome of stress during capture operations—accounts for the highest number of deaths associated with wildlife translocation. These deaths may not only have considerable impacts on conservation efforts but also have direct and indirect financial implications. Such deaths usually are indicative of how well animal welfare was considered and addressed during a translocation exercise. Importantly, devastating consequences on the continued existence of threatened and endangered species succumbing to this known risk during capture and movement may result. Since first recorded in 1964 in Kenya, many cases of capture myopathy have been described, but the exact causes, pathophysiological mechanisms and treatment for this condition remain to be adequately studied and fully elucidated. Capture myopathy is a condition with marked morbidity and mortality that occur predominantly in wild animals around the globe. It arises from inflicted stress and physical exertion that would typically occur with prolonged or short intense pursuit, capture, restraint or transportation of wild animals. The condition carries a grave prognosis, and despite intensive extended and largely non-specific supportive treatment, the success rate is poor. Although not as common as in wildlife, domestic animals and humans are also affected by conditions with similar pathophysiology. This review aims to highlight the current state of knowledge related to the clinical and pathophysiological presentation, potential treatments, preventative measures and, importantly, the hypothetical causes and proposed pathomechanisms by comparing conditions found in domestic animals and humans. Future comparative strategies and research directions are proposed to help better understand the pathophysiology of capture myopathy.

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The pathophysiology of rhabdomyolysis in ungulates and rats: towards the development of a rodent model of capture myopathy

et al. 2022

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Capture myopathy (CM), which is associated with the capture and translocation of wildlife, is a life-threatening condition that causes noteworthy morbidity and mortality in captured animals. Such wildlife deaths have a significant impact on nature conservation efforts and the socio-economic wellbeing of communities reliant on ecotourism. Several strategies are used to minimise the adverse consequences associated with wildlife capture, especially in ungulates, but no successful preventative or curative measures have yet been developed. The primary cause of death in wild animals diagnosed with CM stems from kidney or multiple organ failure as secondary complications to capture-induced rhabdomyolysis. Ergo, the development of accurate and robust model frameworks is vital to improve our understanding of CM. Still, since CM-related complications are borne from biological and behavioural factors that may be unique to wildlife, e.g. skeletal muscle architecture or flighty nature, certain differences between the physiology and stress responses of wildlife and rodents need consideration in such endeavours. Therefore, the purpose of this review is to summarise some of the major etiological and pathological mechanisms of the condition as it is observed in wildlife and what is currently known of CM-like syndromes, i.e. rhabdomyolysis, in laboratory rats. Additionally, we will highlight some key aspects for consideration in the development and application of potential future rodent models.

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Physiopathologie et tableaux cliniques des rhabdomyolyses

Cited by 7 publications

References 59 publications

Severe rhabdomyolysis induced by quetiapine and mirtazapine in a French military soldier

Severe rhabdomyolysis induced by quetiapine and mirtazapine in a French military soldier

Conserving wildlife in a changing world: Understanding capture myopathy—a malignant outcome of stress during capture and translocation

The pathophysiology of rhabdomyolysis in ungulates and rats: towards the development of a rodent model of capture myopathy

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