Physiopathologie du diabète

Tenenbaum, Mathie; Bonnefond, Amélie; Froguel, Philippe; Abderrahmani, Amar

doi:10.1016/s1773-035x(18)30145-x

Cited by 6 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In several epidemiological studies, postprandial glycemia is a major independent risk factor for cardiovascular disease in both glucose intolerant and type 2 diabetic patients. People with low glucose tolerance or diabetes often have high postprandial blood glucose levels for long periods [46,47]. Alpha-amylase and alpha-glucosidase are two enzymes responsible for the degradation of carbohydrates.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Mineral Content, Chemical Analysis, In Vitro Antidiabetic and Antioxidant Activities, and Antibacterial Power of Aqueous and Organic Extracts of Moroccan Leopoldia comosa (L.) Parl. Bulbs

Boulfia

Lamchouri

Senhaji

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Medicinal plants are a rich source of bioactive phytochemicals or bionutrients. Studies carried out during the past few decades have shown that these phytochemicals play an important role in preventing metabolic diseases such as cancer and diabetes. The present study was dedicated to the analysis of mineral and chemical composition and evaluation of antidiabetic, antioxidant, and antibacterial properties of aqueous and organic extracts of Leopoldia comosa, a plant with a long history of therapeutic and food use. Mineral content was determined using inductively coupled plasma atomic emission spectroscopy. Chemical composition was carried out by extraction of essential oils, preparation of aqueous and organic extracts, and qualitative and quantitative analysis. The biological study consisted of the evaluation of antidiabetic activity by inhibition of three enzymes, antioxidant activity by five tests, and antibacterial activity by the disc diffusion method. The correlation between chemical composition and antidiabetic and antioxidant properties was explored by PCA. The results showed that L. comosa contains high levels of Fe, K, P, Na, Cu, Mg, and Ca with values, respectively, in the order of 33552, 1843.14, 756.36, 439.65, 303.9, 272.37, and 20.55 mg/kg. Quantitative analysis showed that the diethyl ether extract had the highest content of polyphenols (129.75 ± 0.29 µg GAE/mg E), flavonoids (988.26 ± 0.18 µg QE/mg E), and tannins (30.22 ± 0.15 µg CE/mg E). All extracts of L. comosa possess inhibitory activity of alpha-amylase, alpha-glucosidase, and beta-galactosidase enzymes, mainly the decocted and the acetone extract. The antioxidant results showed that organic extracts are more active than aqueous extracts especially diethyl ether extract which was similarly found to have an antibacterial effect on Listeria innocua and Proteus mirabilis. PCA allowed us to deduce that phenolic compounds, flavonoids, and tannins are strongly correlated with antioxidant and antidiabetic activity. L. comosa may have potential remedy in the prevention of metabolic disease.

show abstract

Section: Antidiabetic Activitymentioning

confidence: 99%

Mineral Content, Chemical Analysis, In Vitro Antidiabetic and Antioxidant Activities, and Antibacterial Power of Aqueous and Organic Extracts of Moroccan Leopoldia comosa (L.) Parl. Bulbs

Boulfia

Lamchouri

Senhaji

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Diabetes is a metabolic disorder that occurs when the body is unable to produce enough insulin or use insulin effectively [1]. It is characterized either by a state of chronic hyperglycaemia or by fasting blood glucose levels above 1.26 g/L (7mmol/L) or above 2 g/L at any time of testing [2].…”

Section: Introductionmentioning

confidence: 99%

“…Although there are different forms of diabetes, the best known are type 1 diabetes and type 2 diabetes [3] [1]. Type 1 diabetes (T1DM) is caused by a deficiency in insulin secretion [4].…”

Section: Introductionmentioning

confidence: 99%

Level of Knowledge, Physical Activity and Dietary Behaviour of Type 2 Diabetics at the Abidjan Diabetes Center

Jean-Paul,

N’Guessan,

Josi-Noelline

et al. 2023

EJNFS

View full text Add to dashboard Cite

Aims: Type 2 diabetes, commonly known as diabetes mellitus, is a major public health problem due to its prevalence worldwide. This chronic disease is the 9th leading cause of death worldwide. However, in addition to medical treatment, its management requires appropriate hygienic and dietary measures, in particular a suitable diet and regular physical activity. The aim of this study was to assess the level of knowledge and practice of physical activity and the quality of the diet of diabetics at the Abidjan Anti-diabetic Center (CADA). Methodology: This study was a survey with 50 diabetics of CADA. A questionnaire sheet served as a data collection tool to research the level of knowledge and practice of physical activity as well as the quality of the diet of the respondents. Results: The results showed that the sample included 38 women (76%) and 12 men (24%) aged between 33 and 75 years. 70% of the respondents had been ill for at least 5 years. The results also showed that 48 (96%) diabetics had a low level of general knowledge of physical activity. Before the diagnosis of diabetes, 45 respondents (90%) had a low level of physical activity. After diagnosis, 37 diabetics (74%) had a low level of physical activity. The results also showed that the proportion of diabetics with a good level of physical activity after the diagnosis of diabetes was statistically higher (p < 0.05) than the proportion of diabetics with a good level of physical activity before the disease. With regard to diet quality, the results show that all patients (100%) had a poor diet quality before the diagnosis of diabetes. After being declared diabetic, only 6% of diabetics surveyed had a good quality diet. Conclusion: It is important to conduct information and awareness-raising campaigns among the general population, and especially among diabetics, on the importance of hygienic-dietary measures, i.e. a suitable diet and regular exercise.

show abstract

“…Diabetes mellitus is characterized by chronic hyperglycemia and disorders of carbohydrate, lipid, and protein metabolism associated with absolute or relative deficits in insulin action and/or secretion [ 1 , 2 ]. The World Health Organization (WHO) has predicted that between 2014 and 2045, the number of people with diabetes will increase from 422 million to approximately 629 million [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Mineral Analysis, In Vitro Evaluation of Alpha-Amylase, Alpha-Glucosidase, and Beta-Galactosidase Inhibition, and Antibacterial Activities of Juglans regia L. Bark Extracts

Boulfia

Lamchouri

Toufik

2021

BioMed Research International

View full text Add to dashboard Cite

In traditional medicine, various parts of the plant Juglans regia L. are used to treat several pathological conditions including diabetes and infectious and periodontal diseases. This includes the bark of Juglans regia. The present study is aimed at evaluating for the first time the mineral composition, investigating the antidiabetic and antibacterial properties of Moroccan J. regia bark, and finally determining the correlations between the chemical composition of the tested extracts and their biological activities. The mineral composition was determined using inductively coupled plasma atomic emission spectroscopy. Then, nine extracts were prepared by different methods and modalities of extractions and investigated for their antidiabetic activities, via tests of inhibition of alpha-amylase, alpha-glucosidase, and beta-galactosidase enzymes, and for their antibacterial activities against six strains involved in infectious diseases and periodontology. Finally, the correlation between the chemical compositions of the different extracts prepared and their antidiabetic and antibacterial potencies was determined by Principal Component Analysis (PCA). J. regia is an important source of mineral elements, mainly Fe (19849.8), K (3487.8), Mg (2631.03), and P (691.02) mg/kg plant material. All the extracts of J. regia possess antidiabetic activity, and in particular, the macerated acetone extract gave the highest inhibitory activity against alpha-amylase ( I C 50 value of 5445.33 ± 82.58 μ g / mL ), alpha-glucosidase ( I C 50 value of 323.7 ± 1.71 μ g / mL ), and beta-galactosidase ( I C 50 value of 811.2 ± 8.32 μ g / mL ). For the results of antibacterial activity, the macerated acetone extract at the concentration of 80 mg/mL was found to be the most active by inducing inhibition diameters of 12, 17, 18, 11, 14.5, and 16 mm against Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, and Listeria innocua, respectively. PCA allowed us to deduce that the extracts richer in polyphenols, in particular, the two acetone and ethanol macerates, have a better antidiabetic activity against alpha-glucosidase as well as a better antibacterial activity. The results of the present study revealed that the aqueous and organic macerate extracts showed a better antidiabetic activity and justified the use of J. regia bark as an antibacterial and antiseptic agent in traditional Moroccan medicine in the treatment of dental affections.

show abstract

Physiopathologie du diabète

Cited by 6 publications

References 34 publications

Mineral Content, Chemical Analysis, In Vitro Antidiabetic and Antioxidant Activities, and Antibacterial Power of Aqueous and Organic Extracts of Moroccan Leopoldia comosa (L.) Parl. Bulbs

Mineral Content, Chemical Analysis, In Vitro Antidiabetic and Antioxidant Activities, and Antibacterial Power of Aqueous and Organic Extracts of Moroccan Leopoldia comosa (L.) Parl. Bulbs

Level of Knowledge, Physical Activity and Dietary Behaviour of Type 2 Diabetics at the Abidjan Diabetes Center

Mineral Analysis, In Vitro Evaluation of Alpha-Amylase, Alpha-Glucosidase, and Beta-Galactosidase Inhibition, and Antibacterial Activities of Juglans regia L. Bark Extracts

Contact Info

Product

Resources

About