Physiology of the motor cortex in polio survivors

Lupu, Vitalie D.; Danielian, Laura E.; Johnsen, J. A.; Vasconcelos, Olavo M.; Prokhorenko, Olga; Jabbari, Bahman; Campbell, W. W.; Floeter, Mary Kay

doi:10.1002/mus.20913

Cited by 11 publications

(13 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, mixed nerve studies (median, ulnar, peroneal, and tibial posterior compound motor action potentials and F-wave responses), performed at the collaborating site (NIH), showed no evidence of neuropathy. 19 No significant difference in frequency of SEP abnormalities between patients with PPS and without PPS may reflect a comparable age between these two groups. In theory, patients of both groups have an equal chance of developing SEP abnormalities due to the remote polio infection in the past.…”

Section: They Included Lengthening Of Tight Ligaments Of Heel Cord (Amentioning

confidence: 98%

Sensory physiology assessed by evoked potentials in survivors of poliomyelitis

et al. 2008

Self Cite

View full text Add to dashboard Cite

Evidence suggests that sensory loss may occur in a proportion of patients affected by poliomyelitis. We hypothesize that sensory problems may be a lasting sequela in some polio survivors. Sensory pathways in polio survivors were evaluated clinically and electrophysiologically using sensory evoked potentials (SEPs). Patients with sensory deficits or abnormal SEPs were further evaluated by magnetic resonance imaging (MRI). Twenty-two patients were studied. The mean age was 64.7 years (age range: 56-81 years). Clinically, sensory impairments were found in 4 patients. Upper limb SEPs were normal. Lower limb SEPs were abnormal in 10 patients. In 1 patient, clinical and electrographic findings correlated with a patch of atrophy in the spinal cord, as shown by MRI. Sensory derangements may be found in a proportion of aging polio survivors. SEP studies may add sensitivity when evaluating sensory function in this cohort. It remains unclear whether these sensory abnormalities are related to remote poliomyelitis. Further studies are necessary.

show abstract

Section: They Included Lengthening Of Tight Ligaments Of Heel Cord (Amentioning

confidence: 98%

Sensory physiology assessed by evoked potentials in survivors of poliomyelitis

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ce phénomène serait aggravé par une activation musculaire intense et prolongée [6]. Enfin, l'hypothèse d'une fatigabilité de la commande motrice d'origine corticale objectivée par l'altération des potentiels évoqués moteurs post-effort est avancée [7].…”

Section: Histoire Naturelle De La Poliomyéliteunclassified

“…Lupu et al ont observé que l'amplitude des PEM était plus altérée après la réalisation d'un effort musculaire chez des sujets atteints de séquelles de poliomyélite exprimant cette fatigue en comparaison de ceux qui ne l'exprimaient pas [7].…”

Section: Fatigueunclassified

Living and aging with poliomyelitis

Tiffreau¹

2009

Lett Med Phys Readapt

View full text Add to dashboard Cite

Les séquelles de poliomyélite affectent plus de 50 000 personnes en France, âgées de plus de 40 ans. À ce stade, les déficiences neuromusculaires séquellaires sont considérées comme stabilisées, mais les patients sont confrontés à des complications tardives. Ces complications sont principalement d'ordre mécanique : ostéoarticulaires ou musculotendineuses, mais également neurologiques ou cardiorespiratoires. De nouveaux symptômes tels que les douleurs, la fatigue, une aggravation des déficiences musculaires sont possibles et altèrent la qualité de vie des patients. Les conséquences tardives de la poliomyélite justifient une surveillance médicale et une prise en charge rééducative. Elles nécessitent également la mise en place de stratégies adaptatives afin de ne pas dépasser en permanence le seuil de fatigabilité. Mots clés Vieillissement · Poliomyélite · Complications tardivesAbstract More than 50,000 people are affected by the consequences of poliomyelitis in France. After the recovery phase, neuromuscular effects caused by poliomyelitis are considered stable but patients suffer from late complications that affect the musculoskeletal, neuromuscular and cardiorespiratory systems. New symptoms such as pain, fatigue and weakness occur and affect quality of life. A medical followup is justified in cases of late complications of poliomyelitis. Rehabilitation may be necessary and coping strategies are also recommended in cases of fatigue and overwork.

show abstract

“…Conversely, recent neurophysiology studies detected changes suggestive of a compensatory functional reorganisation of the motor cortex. [34,35] From a clinical perspective, PPS remains a diagnosis of exclusion and the March of Dimes diagnostic criteriais typically applied. [8,9] Despite coordinated research efforts, the aetiology is not convincingly established, the underlying pathophysiology is not confirmed, [36] and no validated prognostic and monitoring markers currently exist.…”

Section: Introductionmentioning

confidence: 99%

Increased cerebral integrity metrics in poliomyelitis survivors: putative adaptation to longstanding lower motor neuron degeneration

Shing

Lope

McKenna

et al. 2021

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Background: Post-polio syndrome (PPS) has been traditionally considered a slowly progressive condition that affects poliomyelitis survivors decades after their initial infection. Cerebral changes in poliomyelitis survivors are poorly characterised and the few existing studies are strikingly conflicting. Objective: The overarching aim of this study is the comprehensive characterisation of cerebral grey and white matter alterations in poliomyelitis survivors with reference to healthy-and disease-controls using quantitative imaging metrics. Methods: Thirty-six poliomyelitis survivors, 88 patients with ALS and 117 healthy individuals were recruited in a prospective, single-centre neuroimaging study using uniform MRI acquisition parameters. All participants underwent standardised clinical assessments, T1-weighted structural and diffusion tensor imaging. Whole-brain and region-of-interest morphometric analyses were undertaken to evaluate patterns of grey matter changes. Tract-based spatial statistics were performed to evaluate diffusivity alterations in a study-specific whiter matter skeleton. Results: In contrast to healthy controls, poliomyelitis survivors exhibited increased grey matter partial volumes in the brainstem, cerebellum and occipital lobe, accompanied by increased FA in the corticospinal tracts, cerebellum, bilateral mesial temporal lobes and inferior frontal tracts. Polio survivors exhibited increased integrity metrics in the same anatomical regions where ALS patients showed degenerative changes. Conclusions: Our findings indicate considerable cortical and white matter reorganisation in poliomyelitis survivors which may be interpreted as compensatory, adaptive change in response to severe lower motor neuron injury in infancy.

show abstract

Physiology of the motor cortex in polio survivors

Cited by 11 publications

References 28 publications

Sensory physiology assessed by evoked potentials in survivors of poliomyelitis

Sensory physiology assessed by evoked potentials in survivors of poliomyelitis

Living and aging with poliomyelitis

Increased cerebral integrity metrics in poliomyelitis survivors: putative adaptation to longstanding lower motor neuron degeneration

Contact Info

Product

Resources

About