Physiology of Helicobacter pylori

Influence of Culture Conditions on the Fatty Acid Profiles of Laboratory-Adapted and Freshly Isolated Strains of Helicobacter pylori

“…One property that is unusual but characteristic is the fatty acid distribution among the different lipid classes. The phospholipids are predominantly substituted with 14:0 and 19:0 cyclo fatty acids, whereas ␤-hydroxy or unsaturated fatty acids can only be detected, if at all, in small amounts, which may account for unusual membrane properties (4,15,18). The lipopolysaccharide (LPS) of H. pylori is predominantly different from those of other bacteria and has octadecanoic acid (18:0) and longer-chain 3-hydroxy fatty acids, like 3-hydroxy-hexadecanoic acid (3-OH 16:0) and 3-hydroxy-octadecanoic acid (3-OH 18:0), which may explain the low endotoxic and biological activities of H. pylori LPS (4,(13)(14)(15).…”