Physiology of fever

Broom, M.

doi:10.7748/paed2007.07.19.6.40.c4450

Cited by 18 publications

(24 citation statements)

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“…The hypothesis of a counterregulation provoked by treatment of fever was discussed by Keller et al [13] based on the mathematical models. The origin and mechanisms of thermoregulation of brain and body are very complex and the exact causes of set-point changes are discussed controversially [19][20][21]. Performing a kind of interval cooling to avoid or reduce triggering of potential counterregulation could be an alternative approach to attempt to extend the period of normalized brain temperature.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Resistant Fever: New Method of Local Cerebral Cooling

et al. 2010

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Background Fever in neurocritical care patients is common and has a negative impact on neurological outcome. The purpose of this prospective observational study was (1) to evaluate the practicability of cooling with newly developed neck pads in the daily setting of neurointensive care unit (NICU) patients and (2) to evaluate its effectiveness as a surrogate endpoint to indicate the feasibility of neck cooling as a new method for intractable fever. Methods Nine patients with ten episodes of intractable fever and aneurysmal subarachnoid hemorrhage were treated with one of two different shapes of specifically adapted cooling neck pads. Temperature values of the brain, blood, and urinary bladder were taken close meshed after application of the cooling neck pads up to hour 8.Results The brain, blood, and urinary bladder temperatures decreased significantly from hour 0 to a minimum in hour 5 (P < 0.01). After hour 5, instead of continuous cooling in all the patients, the temperature of all the three sites remounted. Conclusion This study showed the practicability of local cooling for intractable fever using the newly developed neck pads in the daily setting of NICU patients.

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Section: Discussionmentioning

confidence: 99%

Treatment of Resistant Fever: New Method of Local Cerebral Cooling

et al. 2010

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“…47 Fever is the result of endogenous or exogenous pyrogens that reset the hypothalamic set point, resulting in an elevation of body temperature. 7 In contrast to fever, hyperthermia is defined as an elevation of body temperature secondary to heat production, exceeding the body's ability to effectively dissipate heat. 4 Normal body processes that cool the body during times of heat stress, such as vasodilation and sweating, are not active during times of fever.…”

Section: Effects Of Exercise On the Immune Systemmentioning

confidence: 99%

“…4 Normal body processes that cool the body during times of heat stress, such as vasodilation and sweating, are not active during times of fever. 4,7 Fever is a multistep adaptive response to a variety of conditions, with the most common being infection. 7 This adaptive response is initiated by pyrogens that can be either endogenous or exogenous.…”

Section: Effects Of Exercise On the Immune Systemmentioning

confidence: 99%

“…4 The amplitude of febrile response depends on the number of circulating cytokines and prostaglandins, combined with the body's naturally occurring antipyretic molecules. 7 Sources differ on what is considered normal body temperature. Critical analysis suggests that the normal body temperature in young adults averages 98.2°F ± 0.7°F, with a nadir approximately 3 hours before waking and a peak 12 to 14 hours after waking.…”

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confidence: 99%

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Febrile Illness in the Athlete

Dick

Diehl

2013

Sports Health

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Context:Acute febrile illnesses are common in athletes over the course of training and competition seasons. Complete recovery and rapid yet safe return to participation are critical for competitive athletes. Alterations in thermoregulation, metabolism, fluid homeostasis, muscle strength, and endurance, as well as potential complications for the athlete and others, must be considered.Evidence Acquisition:The PubMed database was searched (1970-2013) for all English-language articles related to febrile illness in sport, using the keywords fever, febrile, body temperature, thermoregulation, infection, illness, disease, exercise, athlete, sport, performance, return to play, metabolism, hydration, and dehydration.Study Design:Clinical review.Level of Evidence:Level 4.Results:Limited data confirm that febrile illness is correlated with alterations in the body’s thermoregulatory system, with increases in metabolic rate, and with effects in fluid homeostasis. Human and animal studies demonstrate a decrease in muscle strength and endurance secondary to muscle catabolism in febrile illness. However, indirect evidence suggests that regular exercise enhances the immune response. No strong clinical research has been published on return to play during or following acute febrile illness, excluding mononucleosis and myocarditis.Conclusion:Fever is correlated with an increase in insensible fluid losses, dehydration, metabolic demands, and dysregulation of body temperature. Fever can have detrimental effects on the musculoskeletal system, including decreasing strength and endurance, generalized muscle catabolism, and increase in perceived fatigue. Participating in strenuous exercise during febrile illness can worsen the illness and has demonstrated increased lethality in animal models. No consensus recommendations support return to activity before resolution of fever, and training should be resumed gradually once fever and dehydration have resolved.

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“…According to some authors, non-malarial fevers can suppress low levels of parasitaemia through cytokine production [28]. Moreover, fever itself is a natural mechanism of defense, because it raises body temperature, increases the metabolic activities and makes the immune response more efficient [29-31]; it may, therefore, hinder the development of the parasite [32]. Conversely, others say fever can reduce the individual immunity and the low parasitaemia will be quickly boosted to reach the pyrogenic threshold and thus clinical malaria.…”

Section: Introductionmentioning

confidence: 99%

Distribution of Plasmodium falciparum gametocytes and malaria-attributable fraction of fever episodes along an altitudinal transect in Western Cameroon

Tchuinkam

Nyih-Kong

Fopa

et al. 2015

Malar J

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Background: Highland areas are hypoendemic zones of malaria and are therefore prone to epidemics, due to lack of protective immunity. So far, Cameroon has not succeeded in implementing a convenient and effective method to detect, prevent and forecast malaria epidemic in these peculiar zones. This monitoring and evaluation study aims to assess the operational feasibility of using the human malaria infectious reservoir (HMIR) and the malaria-attributable fraction of fever episodes (MAFE) as indicators, in designing a malaria epidemic early warning system (MEWS).

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Physiology of fever

Cited by 18 publications

References 0 publications

Treatment of Resistant Fever: New Method of Local Cerebral Cooling

Treatment of Resistant Fever: New Method of Local Cerebral Cooling

Febrile Illness in the Athlete

Distribution of Plasmodium falciparum gametocytes and malaria-attributable fraction of fever episodes along an altitudinal transect in Western Cameroon

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