Physiology of Bone Formation, Remodeling, and Metabolism

Kini, Usha; Nandeesh, B N

doi:10.1007/978-3-642-02400-9_2

Cited by 229 publications

(261 citation statements)

References 76 publications

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“…This situation has to do with the release of Ca 2+ through the lyse of hydroxyapatite crystals from the bone fraction, but also from the free fraction mobilization as a consequence of osteclasts' stimulated activity enhanced at fragment reabsorptions and fracture end tops. During the first 24 hours post-trauma an acute inflammatory response is established releasing strong and important inflammatory mediators, namely IL-1, IL-6 and TNF-α, responsible among other things for the increased distance between top ends and certainly the indirect bone regeneration process 16,17,18,19,20,21,22 .…”

Section: Discussionmentioning

confidence: 99%

Serum Ionized Calcium Variations in Simple and Comminuted Fractures in the Dog’s Appendicular Skeleton and Consequent Risks of a Hypercalcemic Condition

2017

ARC Journal of Animal and Veterinary Sciences

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Section: Discussionmentioning

confidence: 99%

Serum Ionized Calcium Variations in Simple and Comminuted Fractures in the Dog’s Appendicular Skeleton and Consequent Risks of a Hypercalcemic Condition

2017

ARC Journal of Animal and Veterinary Sciences

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“…Osteoblasts have the capacity to secrete bone matrix, during the differentiation process and part of them are immobilized and involved in their own bone matrix and give rise to osteocytes ( Figure 3) [40,41]. These are the most abundant cells in bone, representing 90-95% of the total bone cells [36].…”

Section: Osteocytesmentioning

confidence: 99%

“…Indeed, it is precisely in the third decade when bone mass is at the maximum, and this is maintained with small variations until the age of 50. Posteriorly, resorption predominates and bone mass start to decrease [3,40,43].…”

Section: Bone Remodelingmentioning

confidence: 99%

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Neto¹,

Ferreira²

2018

Preprint

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Bone is a dynamic tissue with the capacity of repair and regeneration in specific conditions. Nevertheless, due to the increased incidence of bone disorders, the need of bone grafts has been growing over the past decades and the development of a bone graft with optimal properties remains a clinical challenge. This review addresses the bone properties (morphology, composition and their repair and regeneration capacity) and then is focused on the potential strategies for bone repair and regeneration. It describes the requirements for designing a suitable scaffold material, types of materials (polymers, ceramics and composites) and techniques to obtain the porous structures (additive manufacturing techniques/robocasting or derived from marine skeletons) for bone tissue engineering applications. The main objective of this review is to gather the knowledge on the materials and methods for the production of scaffolds for bone tissue engineering and highlight that natural materials, namely the marine skeletons represent a promising alternative.

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“…The OPG is a RANKL inhibitor; it binds with high affinity to RANKL and prevents its interaction with RANK on the osteoclast. Therefore, OPG downregulates osteoclast formation and prevents osteoporosis 6,7 . Both estrogens and the TGF-beta increase the production of OPG, consequently decreasing the differentiation and activation of osteoclasts and inducing apoptosis 6 .…”

mentioning

confidence: 99%

“…Therefore, OPG downregulates osteoclast formation and prevents osteoporosis 6,7 . Both estrogens and the TGF-beta increase the production of OPG, consequently decreasing the differentiation and activation of osteoclasts and inducing apoptosis 6 . Thus, the high rate of bone resorption observed when the suppression of this hormone occurs can be explained.…”

mentioning

confidence: 99%

Effect of ovariectomy in bone structure of mandibular condyle

et al. 2017

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Effect of ovariectomy in bone structure of mandibular condyle 1 6-Experimental SurgeryActa Cir Bras. 2017;32(10):843-852 AbstractPurpose: To evaluate the bone structure of the mandibular condyle through an animal model, after ovariectomy. Methods: Thirty-six female Wistar rats were divided into 2 groups. The OVX group was submitted to bilateral ovariectomy, the SHAM group underwent the same surgical treatment, but without removal of the ovaries. After 90, 105 and 135 days after surgery, six animals from each group were submitted to euthanasia and the part containing the condyle was removed.Results: The microscopic analysis shows an increase in marrow spaces over time in the OVX group. The morphometric study shows reduction in the amount of bone tissue in the OVX group 135 days period in comparison with for the initial period (90 days) (p <0.05, ANOVA, Tukey). Conclusion:The estrogen deficiency also affects the bone structure of the condyle.

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Physiology of Bone Formation, Remodeling, and Metabolism

Cited by 229 publications

References 76 publications

Serum Ionized Calcium Variations in Simple and Comminuted Fractures in the Dog’s Appendicular Skeleton and Consequent Risks of a Hypercalcemic Condition

Serum Ionized Calcium Variations in Simple and Comminuted Fractures in the Dog’s Appendicular Skeleton and Consequent Risks of a Hypercalcemic Condition

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Effect of ovariectomy in bone structure of mandibular condyle

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