Physiology of ageing

Scott-Warren, Victoria; Maguire, Simon

doi:10.1016/j.mpaic.2016.10.015

Cited by 5 publications

(2 citation statements)

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“…At old age, a series of physiological changes occur in the organism and, when combined with the environment, these modifications may result in health problems [4]. Among these changes, we have observed modifications in circadian rhythm, a decrease in mobility or physical activity (PA) level, as well as a reduction in sleep duration [5,6].…”

Section: Introductionmentioning

confidence: 99%

Is rest-activity rhythm prospectively associated with all-cause mortality in older people regardless of sleep and physical activity level? The ‘Como Vai?’ Cohort study

Wendt,

Bielemann,

Wehrmeister

et al. 2024

PLoS ONE

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Objective This study aims to test the association of rest-activity rhythm (intradaily variability and interdaily stability) with all-cause mortality in an older adult cohort in Brazil. It also assesses whether the amount of time spent at each intensity level (i.e., physical activity and nocturnal sleep) interferes with this association. Methods This cohort study started in 2014 with older adults (≥60 years). We investigated deaths from all causes that occurred until April 2017. Rest-activity rhythm variables were obtained using accelerometry at baseline. Intradaily variability indicates higher rhythm fragmentation, while interdaily stability indicates higher rhythm stability. Cox proportional-hazard models were used to test the associations controlling for confounders. Results Among the 1451 older adults interviewed in 2014, 965 presented valid accelerometry data. During the follow-up period, 80 individuals died. After adjusting the analysis for sociodemographic, smoking, morbidity score, and number of medicines, an increase of one standard deviation in interdaily stability decreased 26% the risk of death. The adjustment for total sleep time and inactivity did not change this association. On the other hand, the association was no longer significant after adjusting for overall physical activity and moderate to vigorous physical activity. Conclusion Rest-activity rhythm pattern was not associated with mortality when physical activity was considered, possibly because this pattern could be driven by regular exercise. Promoting physical activity remains a relevant strategy to improve population health.

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Section: Introductionmentioning

confidence: 99%

Is rest-activity rhythm prospectively associated with all-cause mortality in older people regardless of sleep and physical activity level? The ‘Como Vai?’ Cohort study

Wendt,

Bielemann,

Wehrmeister

et al. 2024

PLoS ONE

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“…This is known as ventilation perfusion mismatch and is clinically manifest as a reduced arterial oxygen tension with consequent increased risk of perioperative hypoxia in the elderly. The lung volume changes in the elderly are demonstrated in(Chan & Welsh, 1998;Scott- Warren & Maguire, 2017).…”

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confidence: 99%

A study of work ability and associated factors in aging office workers with non-communicable diseases and musculoskeletal disorders

Rawdeng

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Aging workers has been linked with high prevalence of both musculoskeletal disorders (MSDs) and non-communicable diseases (NCDs). Health status has a significant impact on work ability. This study compared work ability, using the Work Ability Index (WAI), among aging office workers with and without MSDs and NCDs and determined factors associated with WAI scores. A cross-sectional study was conducted among office workers aged between 45-60 years. An online questionnaire was adopted to collect data. Analyses were conducted using Mann-Whitney U test and multivariable logistic regression model. The results of 689 workers, 34%, 13%, 12%, and 41% reported MSDs, NCDs, MSDs + NCDs, and no MSDs / NCDs, respectively, in the past year. Median scores (interquartile range) of WAI were 37.0 (6) for MSDs, 37.0 (4) for NCDs, 34.5 (6) for MSDs + NCDs, and 40.0 (4) for no MSDs / NCDs. Significant difference in WAI scores was found between the MSDs and MSDs + NCDs (p < 0.05); and between the NCDs and MSDs + NCDs (p < 0.05). Female (ORadj 1.77, 95% CI: 1.2 2.6), high work experience (ORadj 1.04, 95% CI: 1.0 1.1), and low job control (adjusted OR 0.95, 95% CI: 0.9 1.0) were associated with reduced WAI scores (WAI ? 36). Aging office workers with either MSDs or NCDs had reduced work ability compared to healthy workers. Having MSDs + NCDs further reduced work ability. Attention is needed to develop interventions to reduce the impact of MSDs and NCDs on work ability in aging office workers.

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