1981
DOI: 10.1007/bf01857093
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Physiology and pathology of rheumatoid factors

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Cited by 46 publications
(18 citation statements)
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“…A limitation of this study was the absence, from the trial data available to us, of information on rheumatoid factor, which may affect response to treatment (22,23). In addition, only 3 trials had HAQ data available as a measure of physical function, with the remainder of trials providing grip strength data.…”
Section: Discussionmentioning
confidence: 99%
“…A limitation of this study was the absence, from the trial data available to us, of information on rheumatoid factor, which may affect response to treatment (22,23). In addition, only 3 trials had HAQ data available as a measure of physical function, with the remainder of trials providing grip strength data.…”
Section: Discussionmentioning
confidence: 99%
“…It is well established that there is a direct correlation between the severity of the disease and the titer of these antibodies in patients with RA (19,43). Although the precise pathogenic role of RF in RA has not been defined, a great deal of evidence suggests its participation in sustaining inflammatory synovitis (5,38,43).…”
mentioning
confidence: 99%
“…Hybridization studies indicate that the human germ line contains only 25-50V1 genes (18,26,34,35). Strong selective pressures must have operated to conserve the basic RF V1 sequence during the evolution and dispersion of the human species (36,37). Possibly, the V1(Rf)-encoded light chain, in combination with an appropriate heavy chain, generates an antibody against an important environmental pathogen.…”
Section: Resultsmentioning
confidence: 99%