Physiologically-based toxicokinetic modeling of human dermal exposure to diethyl phthalate: Application to health risk assessment

Hu, Man; Zhang, Yining; Zhan, Mei; He, Gengsheng; Qu, Weidong; Zhou, Ying

doi:10.1016/j.chemosphere.2022.135931

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…In the drug review process conducted by the United States Food and Drug Administration (FDA), submitted PBTK models from drug developers were assessed for adequacy at different stages of drug development to achieve desired objectives. Previous studies had solely focused on developing rat-based PBTK models to assess risks associated with oral exposure to diethyl phthalate (DEP), and Hu et al [5] developed a human dermal pathway-specific model for assessing health risks when exposed to DEP, which suggested that dermal exposure to DEP posed a greater risk to human health compared with oral exposure.…”

Section: Introductionmentioning

confidence: 99%

The Application of a Physiologically Based Toxicokinetic Model in Health Risk Assessment

Chen,

Du,

Zhang

et al. 2023

Toxics

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Toxicokinetics plays a crucial role in the health risk assessments of xenobiotics. Classical compartmental models are limited in their ability to determine chemical concentrations in specific organs or tissues, particularly target organs or tissues, and their limited interspecific and exposure route extrapolation hinders satisfactory health risk assessment. In contrast, physiologically based toxicokinetic (PBTK) models quantitatively describe the absorption, distribution, metabolism, and excretion of chemicals across various exposure routes and doses in organisms, establishing correlations with toxic effects. Consequently, PBTK models serve as potent tools for extrapolation and provide a theoretical foundation for health risk assessment and management. This review outlines the construction and application of PBTK models in health risk assessment while analyzing their limitations and future perspectives.

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Section: Introductionmentioning

confidence: 99%