2023
DOI: 10.1007/s12272-023-01472-z
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Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes

Chang-Keun Cho,
Pureum Kang,
Choon-Gon Jang
et al.
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Cited by 3 publications
(1 citation statement)
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“…The metabolism of ARBs by CYP2C9, has been a focal point of recent pharmacogenomic research. Studies have investigated the relationship between CYP2C9 polymorphisms and the response to irbesartan [ 28 ], utilizing physiologically based pharmacokinetic (PBPK) modeling for predicting drug pharmacokinetics across various CYP2C9 genotypes [ 29 ]. Despite these efforts, research by Liu et al .…”
Section: Discussionmentioning
confidence: 99%
“…The metabolism of ARBs by CYP2C9, has been a focal point of recent pharmacogenomic research. Studies have investigated the relationship between CYP2C9 polymorphisms and the response to irbesartan [ 28 ], utilizing physiologically based pharmacokinetic (PBPK) modeling for predicting drug pharmacokinetics across various CYP2C9 genotypes [ 29 ]. Despite these efforts, research by Liu et al .…”
Section: Discussionmentioning
confidence: 99%