Abstract:Aim Long-acting cabotegravir and rilpivirine have been approved to
manage HIV in adults, but data regarding safe use in pregnancy are
limited. Physiologically-based pharmacokinetic modelling (PBPK) can
predict drug disposition in complex populations. Approved dosing
regimens were simulated in pregnancy to explore if Ctrough was
maintained above target concentrations (664 ng/ml and 50 ng/ml
respectively). Methods An adult PBPK model was developed and validated
using clinical data of cabotegravir and rilpivirine… Show more
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