Physiologically Based Pharmacokinetic Modelling

Abstract

This chapter presents the readers with a primer on the subject of physiologically based pharmacokinetic (PBPK) modelling. It discusses the theory and principles of PBPK modelling, and compares and contrasts it with classical pharmacokinetic modelling. It describes the multiple steps involved in developing PBPK models, and includes a compilation, with complete referencing, of published PBPK models for environmental chemicals that have been developed to date. The many applications of PBPK modelling to address issues in toxicology and health risk assessment are discussed with relevant examples. It concludes with some discussion of the problems and limitations in PBPK modelling, and offers some observations about future directions for this rapidly emerging field.

Medical image of the week: acute pneumonitis secondary to boric acid exposure

“…toxicologically important chemical substances, both volatile and nonvolatile Leung 1993). PBPK models for a particular substance require estimates of the chemical substancespecific physicochemical parameters, and species-specific physiological and biological parameters.…”

Characterizing Golden Eagle Risk to Lead and Anticoagulant Rodenticide Exposure: A Review

“…In the early 1990s, validated PBPK models were developed for a number of toxicologically important chemical substances, both volatile and nonvolatile Leung 1993). PBPK models for a particular substance require estimates of the chemical substancespecific physicochemical parameters, and species-specific physiological and biological parameters.…”

Immune System Modifications Induced in a Mouse Model of Chronic Exposure to90Sr

“…The PBPK model for a chemical substance is developed in four interconnected steps: (1) Leung 1993). PBPK models for a particular substance require estimates of the chemical substancespecific physicochemical parameters, and species-specific physiological and biological parameters.…”