Physiologically based pharmacokinetic modeling of ethyl acetate and ethanol in rodents and humans

Crowell, Susan; Smith, Jordan N.; Creim, Jeffrey A.; Faber, Willem; Teeguarden, Justin G.

doi:10.1016/j.yrtph.2015.07.021

Cited by 13 publications

(5 citation statements)

References 18 publications

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“…DBTDL is a common and economic catalyst, CO is bio renewable raw material, 28,29 and EA is an industrially and widely utilized solvent or raw material. 30,31 We studied the reprocessing properties of PUVs with 1 wt%, 2 wt% and 3 wt% catalyst (PUV-1, PUV-2 and PUV-3, respectively) under the same process conditions and quantitatively discussed the mechanical properties of pristine PUVs and reprocessed PUVs. We also explored the behavior of thermally-induced dual-SME and self-welding.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional polyurethane-vitrimers completely based on transcarbamoylation of carbamates: thermally-induced dual-shape memory effect and self-welding

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Multifunctional polyurethane-vitrimers completely based on transcarbamoylation of carbamates: thermally-induced dual-shape memory effect and self-welding

et al. 2017

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“…In recent years, PBPK modeling has found successful applications in drug discovery and development and to support human risk assessment at regulatory agencies . A growing number of PBPK models have been developed for PAHs. ,− This novel metabolism data will allow further development of phenanthrene and retene PBPK models.…”

Section: Discussionmentioning

confidence: 99%

Activity-Based Protein Profiling to Probe Relationships between Cytochrome P450 Enzymes and Early-Age Metabolism of Two Polycyclic Aromatic Hydrocarbons (PAHs): Phenanthrene and Retene

Gaither,

Garcia,

Tyrrell

et al. 2024

Chem. Res. Toxicol.

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A growing body of literature has linked early-life exposures to polycyclic aromatic hydrocarbons (PAH) with adverse neurodevelopmental effects. Once in the body, metabolism serves as a powerful mediator of PAH toxicity by bioactivating and detoxifying PAH metabolites. Since enzyme expression and activity vary considerably throughout human development, we evaluated infant metabolism of PAHs as a potential contributing factor to PAH susceptibility. We measured and compared rates of phenanthrene and retene (two primary PAH constituents of woodsmoke) metabolism in human hepatic microsomes from individuals ≤21 months of age to a pooled sample (n = 200) consisting primarily of adults. We used activity-based protein profiling (ABPP) to characterize cytochrome P450 enzymes (CYPs) in the same hepatic microsome samples. Once incubated in microsomes, phenanthrene demonstrated rapid depletion. Best-fit models for phenanthrene metabolism demonstrated either 1 or 2 phases, depending on the sample, indicating that multiple enzymes could metabolize phenanthrene. We observed no statistically significant differences in phenanthrene metabolism as a function of age, although samples from the youngest individuals had the slowest phenanthrene metabolism rates. We observed slower rates of retene metabolism compared with phenanthrene also in multiple phases. Rates of retene metabolism increased in an age-dependent manner until adult (pooled) metabolism rates were achieved at ∼12 months. ABPP identified 28 unique CYPs among all samples, and we observed lower amounts of active CYPs in individuals ≤21 months of age compared to the pooled sample. Phenanthrene metabolism correlated to CYPs 1A1, 1A2, 2C8, 4A22, 3A4, and 3A43 and retene metabolism correlated to CYPs 1A1, 1A2, and 2C8 measured by ABPP and vendor-supplied substrate marker activities. These results will aid efforts to determine human health risk and susceptibility to PAHs exposure during early life.

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“…Regarding the toxicity of the four components of our new compound contrast agent, no adverse reactions have been reported when they were used in small doses [ [36] , [37] , [38] , [39] ]. NaI, the first-generation X-ray contrast agent [ 37 ] has been extensively used in medicine for treating respiratory and thyroid diseases.…”

Section: Discussionmentioning

confidence: 99%

The exploration of a compound cone-beam CT contrast agent for diagnosis of human extracted cracked tooth

Hu,

et al. 2024

Heliyon

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Physiologically based pharmacokinetic modeling of ethyl acetate and ethanol in rodents and humans

Cited by 13 publications

References 18 publications

Multifunctional polyurethane-vitrimers completely based on transcarbamoylation of carbamates: thermally-induced dual-shape memory effect and self-welding

Multifunctional polyurethane-vitrimers completely based on transcarbamoylation of carbamates: thermally-induced dual-shape memory effect and self-welding

Activity-Based Protein Profiling to Probe Relationships between Cytochrome P450 Enzymes and Early-Age Metabolism of Two Polycyclic Aromatic Hydrocarbons (PAHs): Phenanthrene and Retene

The exploration of a compound cone-beam CT contrast agent for diagnosis of human extracted cracked tooth

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