Physiologically‐based pharmacokinetic model of in vitro porcine ear skin permeation for drug delivery research
Laura Krumpholz,
Sebastian Polak,
Barbara Wiśniowska
Abstract:In silico techniques, such as physiologically based pharmacokinetic modeling (PBKP), are recently gaining importance. Computational methods in drug discovery and development and the generic drugs industry enhance research effectiveness by saving time and money and avoiding ethical issues. One key advantage is the ability to conduct toxicology studies without risking harm to living beings. This study aimed to repurpose the multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) PBPK model for sim… Show more
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