Physiologically based absorption modeling to predict the bioequivalence of two apixaban formulations
Ting Luo,
Lu Wang,
Zourong Ruan
et al.
Abstract:The equivalence of absorption rates and extents between generic drugs and their reference formulations is crucial for ensuring therapeutic comparability. Bioequivalence (BE) studies are widely utilized and play a pivotal role in substantiating the approval and promotional efforts for generic drugs. Virtual BE simulation is a valuable tool for mitigating risks and guiding clinical BE studies, thereby minimizing redundant in vivo BE assessments. Herein, we successfully developed a physiologically based absorptio… Show more
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