PHYSIOLOGICAL STATE OF
            <i>ESCHERICHIA COLI</i>
            AND THE INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS BY PHENETHYL ALCOHOL

Treick, Ronald W.; Konetzka, Walter A.

doi:10.1128/jb.88.6.1580-1584.1964

Cited by 82 publications

(22 citation statements)

References 9 publications

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“…Findings demonstrating non-specificity of the inhihitor have been reported for other organisms as well (Slepecky 1963. Xonoyama and Ikeda 1964, White and White 1964, Treick and Konetzka 1964, Kosenkranz et al 1964).…”

Section: Introductionmentioning

confidence: 72%

Effects of Phenylethyl Alcohol on Chlorella pyrenoidosa

Knutsen

1966

Physiologia Plantarum

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Asynchronous as well as synchronous cultures were used to study the effect of phenylethyl alcohol on Chlorella pyrenoidosa. The following observations were made: Autotrophic growth and the synthesis of DNA and chlorophyll were inhibited more than 80% by 8.4 mM phenylethyl alcohol when added to synchronous suspensions containing autospores. Autospore formation did not occur when fully grown cells capable of division were transferred to 4.2 mM phenylethyl alcohol. Photosynthetic oxygen evolution of asynchronous cultures was inhibited more than 70 % by 21 mM phenylethyl alcohol. Endogenous respiration in the dark was stimulated by 8.4 mM, while higher concentrations were inhibitory. Glucose respiration in the dark was inhibited by all concentrations in the range from 8.4 mM to 21 mM. Assimilation of glucose in darkness was retarded by phenylethyl alcohol at concentrations which gave maximal stimulation of endogenous respiration. It is concluded that phenylethyl alcohol is not a specific inhibitor of DNA synthesis. The prime effect appears to be on respiration and photosynthesis.

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Section: Introductionmentioning

confidence: 72%

Effects of Phenylethyl Alcohol on Chlorella pyrenoidosa

Knutsen

1966

Physiologia Plantarum

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“…It was reported that the bacteriostatic action of phenethyl alcohol was characterized by the specific and reversible inhibition of DNA synthesis [3]. It was reported that the DNA being replicated at the time of phenethyl alcohol addition completes its replication cycle and, although there is gal net synthesis of RNA and protein, no initiation of a second cycle of DNA replication occurs until the removal of the inhibitor [19].…”

Section: Discussionmentioning

confidence: 99%

Replication and Transfer of the R Factor in a Synchronized Culture of Escherichia coli

Yabe

Mitsuhashi

1971

Japanese Journal of Microbiology

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According to mutation mapping after nitrosoguanidine treatment of successive samples obtained from a synchronized culture of Escherichia coli K12 carrying an R factor, it was found that the majority of mutations of the R factor were produced after a maximum peak of galactose mutant production. According to the order of the chromosome replication and the initiation point of the replication, these facts suggest that the replication of the R factor occurs after the replication of the galactose gene. The transfer frequency of the R factor from a synchronized donor culture to the nonsynchronized recipient was the highest after the replication of the chloramphenicol gene on the R factor, probably after the replication of the R factor genome. The recipient ability of the R factor in a synchronized recipient culture from a nonsynchronized donor was the highest after a maximum peak of the galactose mutation, and probably after the cell division in the recipient.

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“…Alcohpl on Bacterial Generation-The effect of phenethyl alcohol on the generation of E. coli NlHJ JC-2 was measured to ascertain the concentration which wdbld effectively retard bacterial generation by the inhibition of DNA synthesis (9). The results ( Fig.…”

Section: Effect Of C E L L Cycle At the Time Of Drug Addition-effect mentioning

confidence: 99%

Kinetic Analysis and Characterization of the Bacterial Regrowth after Treatment of Escherichia coli with β-Lactam Antibiotics

Hamano

Tsuji

Asano

et al. 1984

Journal of Pharmaceutical Sciences

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PHYSIOLOGICAL STATE OF ESCHERICHIA COLI AND THE INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS BY PHENETHYL ALCOHOL

Cited by 82 publications

References 9 publications

Effects of Phenylethyl Alcohol on Chlorella pyrenoidosa

Effects of Phenylethyl Alcohol on Chlorella pyrenoidosa

Replication and Transfer of the R Factor in a Synchronized Culture of Escherichia coli

Kinetic Analysis and Characterization of the Bacterial Regrowth after Treatment of Escherichia coli with β-Lactam Antibiotics

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