Physiological Sleep Tendency on a Simulated Night Shift: Adaptation and Effects of Triazolam

Alertness, performance and off-duty sleep on 8-hour and 12-hour night shifts in a simulated continuous operations control room setting

“…However, the main finding in this study is that objectively measured alertness did not differ between 12-hr and 8-hr shifts. There was improvement in objective alertness across nights of shift in both protocols, which corroborates previous laboratory simulation studies of 8-hr night shifts (Walsh et al, 1988).…”

“…The MSLT is a standard pxucedm for determining sleep tendency and impaired alertness, used widely in clinical and research settings (Carskadon and Dement, 1981; (Carskadon and Dement, 1981;Walsh et al, 1988). Previous experimental data can be extrapolated to predict sleep latency for each hour in any given shiftwork scenario, such as the night shifts simulated in the present research study (Fig.…”

Measures to counteract the negative effects of night work

“…Several simulation studies of shift work have shown increased daytime sleep following administration of hypnotics such as triazolam, zopiclone, flunitrazepam, estazolam, and temazepam in the morning (102)(103)(104)(105)(106)(107), but findings regarding alertness or performance-enhancing effects on the following night shift are more equivocal. Some studies have reported no improvement (104,108) while others have noted improved alertness and performance (102,105,106).…”

A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Armodafinil for Excessive Sleepiness Associated With Jet Lag Disorder

“…Similar findings have been seen in connection with other circadian rhythm disorders. 22 To our knowledge, this is the first clinical study to evaluate a wakefulness-promoting medication in a population with a history of jet lag symptoms. Other medications have been studied to treat the excessive sleepiness or insomnia symptoms associated with jet lag disorder, such as melatonin, tasimelteon, and slow-release caffeine.…”