Physiological significance of coronary flow velocity and changing stenosis geometry during coronary vasodilation in awake dogs.

Does the quantitative assessment of coronary artery dimensions predict the physiologic significance of a coronary stenosis?

“…Approaches that integrate all angiographic dimensions are conceptually attractive,2' but limited by the fact that coronary flow is estimated. We used theoretical flows of 1, 2, 31 Therefore, we continued medical treatment, including nitrates and calcium antagonists, in all our patients with CAD on the day of the investigation. Most important to our study, this could affect measurement of the papaverine-induced change in geometry of stenosis.…”

Single-Wire Pressure and Flow Velocity Measurement to Quantify Coronary Stenosis Hemodynamics and Effects of Percutaneous Interventions

“…20 However, patients in the present study received intracoronary nitroglycerin every 30 minutes throughout the procedure to vasodilate the epicardial vessels before hyperemia was induced. In contrast, coronary artery stenoses are frequently at least partially compliant, and stenosis dimensions then depend on intrastenotic pressure.…”

Study of Coronary Flow Reserve with Intravenous Use of Microbubbles (Contrast Echocardiography) and Adenosine: Protocol for Clinical Application in Patients Suspected of Having Coronary Heart Disease

“…A great intra-and interobserver variation exists [27][28][29] , as well as a limited capacity of the observers to predict the hemodynamic significance of a certain coronary stenosis 30,31 . Quantitative coronary angiography improved the evaluation of the degree of coronary stenosis 32 , but limitations still persist 33,34 . In addition, the demonstration of the stenosis and its degree does not describe the level of the perfusion defect, or the myocardial area involved.…”