“…The quality and strength of the perceived sensations from tobacco and nicotine exposure play an important role in the maintenance of cigarette smoking behavior and the development of nicotine dependence (Eissenberg & Balster, 2000;Pomerleau & Pomerleau, 1992;Pomerleau & Pomerleau, 1994;Shadel, Shiffman, Niaura, Nichter, & Abrams, 2000). Although the causal mechanisms are not yet fully understood, cumulative biological, psychological, and behavioral research on cigarette smoking and nicotine dependence suggests that initial sensations from nicotine exposure may provide important indicators of an individual's vulnerability to nicotine and the subsequent development of nicotine dependence (Eissenberg & Balster, 2000;Hirschman, Leventhal, & Glynn, 1984;Jones, 1986;Pomerleau, 1995;Pomerleau, Pomerleau, & Namenek, 1998;Wang, Fitzhugh, Trucks, Cowdery, & Perko, 1995). These studies suggest that sensations from the first few exposures may be particularly important.…”