Physiological senile involution and pathological rarefaction of bone

Meunier, Pierre J.; Courpron, P; Edouard, C.; Bernard, J; Bringuier, J.; Vignon, G

doi:10.1016/s0300-595x(73)80042-8

Cited by 256 publications

(78 citation statements)

References 15 publications

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“…Smith et al (13), however, who studied bone loss with age at the midradius and distal radius using single photon absorptiometry, found that rates of bone We found that the cumulative diminution of BMD from the vertebrae between young adulthood and extreme old age was 47% for women and 14% for men. The overall diminution in women was similar to the value of 43% found by Meunier et al (18), who studied diminution oftrabecularbone mass in iliac-crestbiopsy samples (obtained from normal persons who had died suddenly); in men, however, it was less than the value of 27% that they found. Additionally, the rate of bone diminution with age that we found was threefold greater than was found in a smaller series reported by Madsen (19), who also used dual photon absorptiometry in vivo.…”

Section: Discussionsupporting

confidence: 87%

Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis.

et al. 1981

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A B S T R A C T Patterns ofbone loss in the axial and the appendicular skeleton were studied in 187 normal volunteers (105 women and 82 men; age range, 20-89 yr) and in 76 women and 9 men with vertebral fractures due to osteoporosis. Bone mineral density was measured in vivo at the lumbar spine (predominantly trabecular bone) by dual photon absorptiometry and at the midradius (>95% cortical bone) and distal radius (75% cortical and 25% trabecular bone) by single photon absorptiometry. In normal women, bone diminution from the vertebrae began in young adulthood and was linear. In the appendicular skeleton, bone diminution did not occur until age 50 yr, was accelerated from ages 51 to 65 yr, and then decelerated somewhat after age 65 yr. Overall bone diminution throughout life was 47% for the vertebrae, 30% for the midradius, and 39% for the distal radius. In normal men, vertebral and appendicular bone diminution with aging was minimal or insignificant. Mean bone mineral density was lower in patients with osteoporosis than in age-and sex-matched normal subjects at all three scanning sites, although spinal measurements discriminated best; however, there was considerable overlap. By age 65 yr, half ofthe normal women (and by age 85 yr, virtually all of them) had vertebral bone mineral density values below the 90th percentile of women with vertebral fractures and, thus, might be considered to have asymptomatic osteoporosis. For men, the degree of overlap was less. The data suggest that disproportionate loss of trabecular bone from the axial skeleton is a distinguishing characteristic of spinal osteoporosis.Address reprint requests to Dr. Riggs.

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Section: Discussionsupporting

confidence: 87%

Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis.

et al. 1981

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“…However, in other studies, no significant change with age or sex was noted in resorption area or resorption cavity depth, although these measurements are more likely to reflect osteoclast activity than osteoclast formation (Meunier et al 1973, Croucher et al 1991. Some studies have reported an increase in the extent of resorption in females in their sixth decade (Sedlin et al 1963, Melsen et al 1979, but this has been refuted by others (Meunier et al 1973). Although our findings on osteoclast formation and bone resorption cannot strictly be equated to those of bone histomorphometry studies, it should be noted that post-menopausal females and age-matched males exhibited a similar level of lacunar resorption in our study.…”

Section: Discussionmentioning

confidence: 70%

“…Schenk et al (1969) noted that the extent of Howship's lacunae covered by osteoclasts was similar in all age groups from 20-80 years, indicating a remarkably constant state of osteoclast formation and activity. However, in other studies, no significant change with age or sex was noted in resorption area or resorption cavity depth, although these measurements are more likely to reflect osteoclast activity than osteoclast formation (Meunier et al 1973, Croucher et al 1991. Some studies have reported an increase in the extent of resorption in females in their sixth decade (Sedlin et al 1963, Melsen et al 1979, but this has been refuted by others (Meunier et al 1973).…”

Section: Discussionmentioning

confidence: 91%

“…Most histomorphometry studies which have analysed the number of osteoclasts in bone have shown that this does not exhibit a marked gender difference and that osteoclast numbers in fact varies quite widely within a particular age group (Sedlin et al 1963, Schenk et al 1969, Meunier et al 1973, Melsen et al 1979, Rehman et al 1994. Schenk et al (1969) noted that the extent of Howship's lacunae covered by osteoclasts was similar in all age groups from 20-80 years, indicating a remarkably constant state of osteoclast formation and activity.…”

Section: Discussionmentioning

confidence: 99%

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Gender- and age-related differences in osteoclast formation from circulating precursors

Jevon

Sabokbar²,

Fujikawa³

et al. 2002

Journal of Endocrinology

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A number of bone diseases characterised by excessive osteolysis (e.g. osteoporosis and Paget's disease) exhibit a marked gender difference in prevalence and are more common in the elderly population. Bone resorption is carried out by osteoclasts, which are formed by fusion of circulating mononuclear precursor cells of haematopoietic origin. In this study, we have determined whether there are gender-and age-related differences in osteoclast formation from circulating precursors. (10 5 per well) from males was also noted in response to 10 9 M 1,25(OH) 2 D 3 (P<0·05) and sRANKL (P=0·05), but not M-CSF. The addition of dexamethasone resulted in a marked increase in osteoclast formation and lacunar resorption in both males and females. Post-menopausal females and males of comparable age showed similar levels of osteoclastogenesis. Pre-menopausal women showed similar levels of osteoclastogenesis but less resorption (P=0·01) compared with males of comparable age. These results show that there are specific gender/age-related differences in osteoclast formation and bone resorption and have implications for evaluating osteoclastogenesis in skeletal diseases such as primary osteoporosis and Paget's disease.

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“…Also, anatomic studies have shown a linear decrease in trabecular bone mass beginning in young adulthood, assessed either by iliac crest biopsy (15)(16)(17) or by postmortum examination of the vertebrae (18,19). However, in a cross-sectional study, Aloia et al (20) found that BMD oflumbar spine did not decrease in women until after age 50 yr. Ruegsegger et al (21) found no significant loss of trabecular bone from the distal radius or tibia (as assessed by computed tomography) over a 24-mo period in 12 premenopausal women.…”

Section: Resultsmentioning

confidence: 99%

Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause.

Riggs

Wahner

Melton³

et al. 1986

J. Clin. Invest.

466

109

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We made longitudinal measurements of bone mineral density (BMD) in 139 normal women (ages 20-88 yr) at midradius (99% cortical bone) and lumbar spine (-70% trabecular bone) by single-and dual-photon absorptiometry. BMD was measured 2-6 (median, 3) times over an interval of 0.8-3.4 yr (median, 2.1 yr). For midradius, BMD did not change (+0.48%/yr, NS) before menopause but decreased (-1.01%/yr, P < 0.001) after menopause. For lumbar spine, there was significant bone loss both before (-132%/yr, P < 0.001) and after (-0.97%/yr, P = 0.006) menopause; these rates did not differ significantly from each other. Our data show that before menopause little, if any, bone is lost from the appendicular skeleton but substantial amounts are lost from the axial skeleton. Thus, factors in addition to estrogen deficiency must contribute to pathogenesis of involutional osteoporosis in women because about half of overall vertebral bone loss occurs premenopausally.

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Physiological senile involution and pathological rarefaction of bone

Cited by 256 publications

References 15 publications

Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis.

Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis.

Gender- and age-related differences in osteoclast formation from circulating precursors

Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause.

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