Physiological role of adiponectin in different tissues: a review

Esmaili, Saeed; Hemmati, Mina; Karamian, Mehdi

doi:10.1080/13813455.2018.1493606

Cited by 41 publications

(30 citation statements)

References 71 publications

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“…16 In contrast to other adipokines, serum adiponectin levels are inversely proportional to body fat content. 17 Adiponectin exerts its actions through two receptors, that is, AdipoR1, which is predominantly expressed in skeletal muscles and AdipoR2 that is found in the liver. AdipoR1 and AdipoR2 are integral membrane receptors composed of seven domains, having an external C-terminus exposed on the outside of the cell and internal, cytoplasm-oriented N-terminus.…”

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confidence: 99%

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

2020

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Summary Adipokines are predominantly known to play a vital role in the control of food intake, energy homeostasis and regulation of glucose and lipid metabolism. However, evidence supporting the concept of their extensive involvement in immune system defence mechanisms and inflammatory processes continues to grow. Some of the adipokines, that is, leptin and resistin, have been recognized to exhibit mainly pro‐inflammatory properties, whereas others such as visfatin, chemerin, apelin and vaspin have been found to exert regulatory effects. In contrast, adiponectin or omentin are known for their anti‐inflammatory activities. Hence, adipokines influence the activity of various cells engaged in innate immune response and inflammatory processes mainly by affecting adhesion molecule expression, chemotaxis, apoptosis and phagocytosis, as well as mediators production and release. However, much less is known about the role of adipokines in processes involving lymphoid lineage cells. This review summarizes the current knowledge regarding the importance of different adipokines in the lymphopoiesis, recirculation, differentiation and polarization of lymphoid lineage cells. It also provides insight into the influence of selected adipokines on the activity of those cells in tissues.

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confidence: 99%

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

2020

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“…Adiponectin represents the most abundant peptide secreted by adipocytes, playing an important role in the metabolism, regulation of anabolic pathways, reduction of oxidative stress, prevention from inflammatory processes, and vascular function improvement [ 26 ]. Misra et al [ 27 ] reported unchanged levels of adiponectin in AN women compared to that of normal-weight controls, however, other studies revealed elevated adiponectin levels [ 28 ] or decreased adiponectin levels (e.g., [ 29 ]).…”

Section: Neuroendocrine System—the Role In An-linked Cardiovasculamentioning

confidence: 99%

Role of Neuroendocrine, Immune, and Autonomic Nervous System in Anorexia Nervosa-Linked Cardiovascular Diseases

Sekaninova

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Višňovcová

et al. 2020

IJMS

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Anorexia nervosa represents a severe mental disorder associated with food avoidance and malnutrition. In patients suffering from anorexia nervosa, cardiovascular complications are the main reason leading to morbidity and mortality. However, the origin and pathological mechanisms leading to higher cardiovascular risk in anorexia nervosa are still unclear. In this aspect, the issue of exact pathological mechanisms as well as sensitive biomarkers for detection of anorexia nervosa-linked cardiovascular risk are discussed. Therefore, this review synthesised recent evidence of dysfunction in multiple neuroendocrine axes and alterations in the immune system that may represent anorexia nervosa-linked pathological mechanisms contributing to complex cardiovascular dysregulation. Further, this review is focused on identification of non-invasive biomarkers for the assessment of increased cardiovascular risk in anorexia nervosa that can be linked to a clinical application. Complex non-invasive assessment of cardiovascular autonomic regulation—cardiac vagal control (heart rate variability), sympathetic vascular activity (blood pressure variability), and cardiovascular reflex control (baroreflex sensitivity)—could represent a promising tool for early diagnosis, personalized therapy, and monitoring of therapeutic interventions in anorexia nervosa particularly at a vulnerable adolescent age.

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“…Furthermore, in obese patients with metabolic syndrome is more common to observe low adiponectin levels [11] and a leptin-resistance state [12]. Leptin is a hormone with orexigenic activity, that helps to regulate energy balance by inhibiting hunger [13], while adiponectin is a peptide synthetized by adipocytes that exhibits anti-inflammatory, anti-atherogenic effects, and it also is an insulin sensitizer [14]. This metabolic dysfunction leads to insulin-resistance with consequences primarily on adipose, muscular, and hepatic tissues [15].…”

Section: Introductionmentioning

confidence: 99%

Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs

et al. 2020

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Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of population and according to the World Health Organization (WHO) the number of adults living with diabetes is expected to increase. Since type 2 diabetes mellitus (T2DM) is suffered by the majority of diabetic patients (around 90–95%) and often the mono-target therapy fails in managing blood glucose levels and the other comorbidities, this review focuses on the potential drugs acting on multi-targets involved in the treatment of this type of diabetes. In particular, the review considers the main systems directly involved in T2DM or involved in diabetes comorbidities. Agonists acting on incretin, glucagon systems, as well as on peroxisome proliferation activated receptors are considered. Inhibitors which target either aldose reductase and tyrosine phosphatase 1B or sodium glucose transporters 1 and 2 are taken into account. Moreover, with a view at the multi-target approaches for T2DM some phytocomplexes are also discussed.

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Physiological role of adiponectin in different tissues: a review

Cited by 41 publications

References 71 publications

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

Role of Neuroendocrine, Immune, and Autonomic Nervous System in Anorexia Nervosa-Linked Cardiovascular Diseases

Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs

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