2018
DOI: 10.1080/13813455.2018.1493606
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Physiological role of adiponectin in different tissues: a review

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Cited by 47 publications
(39 citation statements)
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“…16 In contrast to other adipokines, serum adiponectin levels are inversely proportional to body fat content. 17 Adiponectin exerts its actions through two receptors, that is, AdipoR1, which is predominantly expressed in skeletal muscles and AdipoR2 that is found in the liver. AdipoR1 and AdipoR2 are integral membrane receptors composed of seven domains, having an external C-terminus exposed on the outside of the cell and internal, cytoplasm-oriented N-terminus.…”
mentioning
confidence: 99%
“…16 In contrast to other adipokines, serum adiponectin levels are inversely proportional to body fat content. 17 Adiponectin exerts its actions through two receptors, that is, AdipoR1, which is predominantly expressed in skeletal muscles and AdipoR2 that is found in the liver. AdipoR1 and AdipoR2 are integral membrane receptors composed of seven domains, having an external C-terminus exposed on the outside of the cell and internal, cytoplasm-oriented N-terminus.…”
mentioning
confidence: 99%
“…Adiponectin represents the most abundant peptide secreted by adipocytes, playing an important role in the metabolism, regulation of anabolic pathways, reduction of oxidative stress, prevention from inflammatory processes, and vascular function improvement [ 26 ]. Misra et al [ 27 ] reported unchanged levels of adiponectin in AN women compared to that of normal-weight controls, however, other studies revealed elevated adiponectin levels [ 28 ] or decreased adiponectin levels (e.g., [ 29 ]).…”
Section: Neuroendocrine System—the Role In An-linked Cardiovasculamentioning
confidence: 99%
“…Furthermore, in obese patients with metabolic syndrome is more common to observe low adiponectin levels [11] and a leptin-resistance state [12]. Leptin is a hormone with orexigenic activity, that helps to regulate energy balance by inhibiting hunger [13], while adiponectin is a peptide synthetized by adipocytes that exhibits anti-inflammatory, anti-atherogenic effects, and it also is an insulin sensitizer [14]. This metabolic dysfunction leads to insulin-resistance with consequences primarily on adipose, muscular, and hepatic tissues [15].…”
Section: Introductionmentioning
confidence: 99%