Physiological role and mechanisms of action for a long noncoding haplotype region
Hong Xue,
Manoj K. Mishra,
Yong Liu
et al.
Abstract:Most common sequence variants associated with human traits are in noncoding regions of the genome, form haplotypes with other noncoding variants, and exhibit small effect sizes in the general population. Determining the physiological roles and mechanisms of action for these noncoding variants, particularly large haplotypes containing multiple variants, is both critical and challenging. To address this challenge, we developed an approach that integrates physiological studies in genetically engineered and phenot… Show more
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