Physiological responsivity to emotional pictures in schizophrenia

Hempel, Roelie; Tulen, Joke H.M.; Beveren, Nico J.M. van; Steenis, H.G. van; Mulder, Paul; Hengeveld, Michiel W.

doi:10.1016/j.jpsychires.2004.11.004

Cited by 70 publications

(63 citation statements)

References 40 publications

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“…One possible explanation might be that looking at positive and negative stimuli changes systemic variables in different ways. For example, it has been shown that negative pictures significantly decrease heart rate compared to neutral and positive pictures, and additionally that positive pictures lead to an increase of systolic and diastolic blood pressure compared to neutral and negative stimuli [Hempel et al, 2005;Sarlo et al, 2005]. As it has been shown that heart rate and blood pressure correlate with [O 2 Hb] but not with [HHb] [Mehagnoul Schipper et al, 2000], it might be that the divergent findings for [O 2 Hb] are caused by systemic variables.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of activity of the primary visual cortex during processing of emotional stimuli as measured with event‐related functional near‐infrared spectroscopy and event‐related potentials

Huter

Plichta

Ehlis

et al. 2007

Human Brain Mapping

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In this study we investigated whether event-related near-infrared spectroscopy (NIRS) is suitable to measure changes in brain activation of the occipital cortex modulated by the emotional content of the visual stimuli. As we found in a previous pilot study that only positive but not negative stimuli differ from neutral stimuli (with respect to oxygenated haemoglobin), we now measured the event-related EEG potentials and NIRS simultaneously during the same session. Thereby, we could evaluate whether the subjects (n = 16) processed the positive as well as the negative emotional stimuli in a similar way. During the task, the subjects passively viewed positive, negative, and neutral emotional pictures (40 presentations were shown in each category, and pictures were taken from the International Affective Picture System, IAPS). The stimuli were presented for 3 s in a randomized order (with a mean of 3 s interstimulus interval). During the task, we measured the event-related EEG potentials over the electrode positions O1, Oz, O2, and Pz and the changes of oxygenated and deoxygenated haemoglobin by multichannel NIRS over the occipital cortex. The EEG results clearly show an increased early posterior negativity over the occipital cortex for both positive as well as negative stimuli compared to neutral. The results for the NIRS measurement were less clear. Although positive as well as negative stimuli lead to significantly higher decrease in deoxygenated haemoglobin than neutral stimuli, this was not found for the oxygenated haemoglobin.

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Section: Discussionmentioning

confidence: 99%

Enhancement of activity of the primary visual cortex during processing of emotional stimuli as measured with event‐related functional near‐infrared spectroscopy and event‐related potentials

Huter

Plichta

Ehlis

et al. 2007

Human Brain Mapping

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“…16 Second, emotional experience is often reported to be exaggerated in patients with schizophrenia. [17][18][19] And third, a careful assessment of the neuro imaging literature reveals that only studies using a design with blocks shorter than 28 seconds have reported amygdala activation in schizophrenia. 14,15 We believe that a heightened automatic emotional response could interfere with basic emotional processing and subsequently require compensatory strategies to make emotional judgments.…”

Section: Introductionmentioning

confidence: 99%

“…A consistent body of evidence emphasizes that patients with schizophrenia may have higher sensitivity to negative emotions than healthy participants. [17][18][19] Moreover, higher levels of autonomic arousal to facial emotions have been observed in schizophrenia patients although their limbic activity appears reduced. 13,29 A possible explanation for these data could be that, during emotional processing of threatrelated emotions, schizophrenia patients engage alternative cognitive routes to avoid a potentially exaggerated automatic emotional reaction.…”

mentioning

confidence: 99%

Differential patterns of initial and sustained responses in amygdala and cortical regions to emotional stimuli in schizophrenia patients and healthy participants

Salgado‐Pineda

Fakra

Delaveau

et al. 2010

jpn

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41Background: We sought to investigate the altered brain responses to emotional stimuli in patients with schizophrenia. Methods: We ana lyzed data from 14 patients with schizophrenia and 14 healthy controls who performed an emotional face matching task. We evaluated brain activity and connectivity in the amygdala and cortical regions during the initial (first 21 seconds of each stimulation block) and sustained (last 21 seconds) stages of an emotional processing task, and we determined changes in amygdala activity across the emotional processing task. Results: The patients with schizophrenia showed similar amygdala activation to the controls during the initial stage of processing, but their activation decreased during the sustained stage. The controls showed increasing amygdala activity across the emotional blocks, whereas activity progressively decreased in the schizophrenia group. The patients with schizophrenia showed increased cortical activity and interconnectivity in the medial frontal and inferior parietal cortex in the initial stage of emotional processing. There was increased activity in the superior temporal cortex and greater connectivity with the inferior parietal cortex in the sustained stage. Performance accuracy was lower in the schizophrenia group in the first part of the block, while their reaction time was longer in the latter part of the block. Limitations: It was not possible to specify the moment at which the switch in amygdala response occurred. Conclusion: Our findings suggest that patients with schizophrenia have an initial automatic emotional response but that they need to switch to a compensatory cognitive strategy to solve the task.

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“…Capturing these responses may require alternate stimuli: humour or mimicry for zygomatic activity, 20,38 and exclusively erotic stimuli for SCR. 39 Reduced LPP response in patients was not likely due to treatment with antipsychotics, as we saw no correlation between antipsychotic dose and the pleasant effect (R = 0.00).…”

Section: Discussionmentioning

confidence: 70%

Do reward-processing deficits in schizophrenia-spectrum disorders promote cannabis use? An investigation of physiological response to natural rewards and drug cues

Cassidy

Brodeur

Lepage

et al. 2014

jpn

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Physiological responsivity to emotional pictures in schizophrenia

Cited by 70 publications

References 40 publications

Enhancement of activity of the primary visual cortex during processing of emotional stimuli as measured with event‐related functional near‐infrared spectroscopy and event‐related potentials

Enhancement of activity of the primary visual cortex during processing of emotional stimuli as measured with event‐related functional near‐infrared spectroscopy and event‐related potentials

Differential patterns of initial and sustained responses in amygdala and cortical regions to emotional stimuli in schizophrenia patients and healthy participants

Do reward-processing deficits in schizophrenia-spectrum disorders promote cannabis use? An investigation of physiological response to natural rewards and drug cues

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