Physiological Responses and Evaluation of Effects of BMI, Smoking and Drinking in High Altitude Acclimatization: A Cohort Study in Chinese Han Young Males

Peng, Qianqian; Zhuoma, Basang; Cui, Chaoying; Li, Lei; Qian, Ji; Gesang, Quzhen; La, Yang; La, Zong; De, Yang; Dawa, Puchi; Qu, Ni; Suo, Qu; Dan, Zhen; Xiao, Duoji; Jin, Li

doi:10.1371/journal.pone.0079346

Cited by 17 publications

(35 citation statements)

References 27 publications

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“…Likewise, in lowlanders who migrated to an altitude of 3,500 m, those subjects with a higher BMI were more prone to have bad responses to hypoxia, highlighting that a higher BMI might be a risk factor for poor high-altitude acclimatization [54]. Additionally, during longer CIH shifts (months) at altitudes between 4,630 and 4,905 m, subjects with a BMI > 28 kg/m 2 had a higher PAP (∼31 mm Hg) than those with a BMI of 22-24 kg/m 2 (∼22 mm Hg).…”

Section: Obesity and Chronic Intermittent Exposure To High-altitude Hmentioning

confidence: 99%

Obesity as a Conditioning Factor for High-Altitude Diseases

et al. 2017

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Obesity, a worldwide epidemic, has become a major health burden because it is usually accompanied by an increased risk for insulin resistance, diabetes, hypertension, cardiovascular diseases, and even some kinds of cancer. It also results in associated increases in healthcare expenditures and labor and economic consequences. There are also other fields of medicine and biology where obesity or being overweight play a major role, such as high-altitude illnesses (acute mountain sickness, hypoxic pulmonary hypertension, and chronic mountain sickness), where an increasing relationship among these two morbid statuses has been demonstrated. This association could be rooted in the interactions between obesity-related metabolic alterations and critical ventilation impairments due to obesity, which would aggravate hypobaric hypoxia at high altitudes, leading to hypoxemia, which is a trigger for developing high-altitude diseases. This review examines the current literature to support the idea that obesity or overweight could be major conditioning factors at high altitude.

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Section: Obesity and Chronic Intermittent Exposure To High-altitude Hmentioning

confidence: 99%

Obesity as a Conditioning Factor for High-Altitude Diseases

et al. 2017

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“…Specifically, we calculated sensitivity and specificity of having excessive erythrocytosis (defined as measured hemoglobin concentrations ‡ 21.0 g/dL in males and ‡ 19.0 g/dL in females) for lower threshold value for a range of oxyhemoglobin saturation values. threshold of oxyhemoglobin saturation will likely vary with altitude, body mass index, pregnancy, and behavioral factors such as chronic alcohol drinking and tobacco smoking (Sahota et al, 2013, Peng et al, 2013.…”

Section: Figmentioning

confidence: 99%

Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude

Vyas

Danz

Gilman

et al. 2015

High Altitude Medicine & Biology

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. Noninvasive assessment of excessive erythrocytosis as a screening method for chronic mountain sickness at high altitude. High Alt Med Biol 16:162-168, 2015.-Globally, over 140 million people are at risk of developing chronic mountain sickness, a common maladaptation to life at high altitude ( > 2500 meters above sea level). The diagnosis is contingent upon the identification of excessive erythrocytosis (EE). Current best practices to identify EE require a venous blood draw, which is cumbersome for large-scale surveillance. We evaluated two point-of-care biomarkers to screen for EE: noninvasive spot-check tests of total hemoglobin and oxyhemoglobin saturation (Pronto-7, Masimo Corporation). We conducted paired evaluations of total serum hemoglobin from a venous blood draw and noninvasive, spot-check testing of total hemoglobin and oxyhemoglobin saturation with the Pronto-7 in 382 adults aged ‡ 35 years living in Puno, Peru (3825 meters above sea level). We used the Bland-Altman method to measure agreement between the noninvasive hemoglobin assessment and the gold standard lab hemoglobin analyzer. Mean age was 58.8 years and 47% were male. The Pronto-7 test was unsuccessful in 21 (5%) participants. Limits of agreement between total hemoglobin measured via venous blood draw and the noninvasive, spot-check test ranged from -2.8 g/dL (95% CI -3.0 to -2.5) to 2.5 g/dL (95% CI 2.2 to 2.7), with a bias of -0.2 g/dL (95% CI -0.3 to -0.02) for the difference between total hemoglobin and noninvasive hemoglobin concentrations. Overall, the noninvasive spot-check test of total hemoglobin had a better area under the receiver operating characteristic curve compared to oxyhemoglobin saturation for the identification of EE as measured by a gold standard laboratory hemoglobin analyzer (0.96 vs. 0.82; p < 0.001). Best cut-off values to screen for EE with the Pronto 7 were ‡ 19.9 g/dL in males and ‡ 17.5 g/dL in females. At these cutpoints, sensitivity and specificity were both 92% and 89% for males and females, respectively. A noninvasive, spot-check test of total hemoglobin had low bias and high discrimination for the detection of EE in high altitude Peru, and may be a useful point-of-care tool for large-scale surveillance in high-altitude settings.

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“…(Nourshahi et al, 2011). Another research showed that in high altitudes residents, BMI negatively related to performance at altitude and those who had higher BMI was also more susceptible for hypoxia (Peng et al, 2013). Mountain climbers with higher levels of BMI have been shown to lose more weight in high altitudes.…”

Section: Resultsmentioning

confidence: 99%

“…Ноуршахи и сарадници су испитивали утицај планинарења на физичку кон-дицију старијих људи, а пријављено је да алпи-нисти имају мањи БМИ (7%) у односу на њихове седентарне колеге (Nourshahi, et al, 2011). Друга истраживања су показала да је код становника на великим надморским висинама, БМИ негативно повезан са учинком на надморској висини, а они који су имали већи БМИ су такође били осетљи-вији на хипоксију (Peng, et al, 2013). Алпинисти са вишим нивоима БМИ су показали да губе већу телесну масу на великим надморским висинама.…”

Section: дискусијаunclassified

Association of anthropometric, physiologycal and physical traits to success of elite male mountain climbers

Arazi¹,

Saedi²,

Izadi³

2017

Fizicka kultura

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The purpose of this study was to examine the anthropometric, physiological and physical traits of elite mountain climbers and relationship of these traits to success in mountain climbing. Thirty-eight elite male Iranian mountain climbers (height of 178.68 ± 5.77 cm, body mass index of 23.4 ± 2.78 kg/m 2 and age of 31.26 ± 6.93 years) were assessed for some anthropometric, physiological and physical variables. So that, height, weight, and also length and circumference of limbs were measured. Percent body fat was determined by 3 sites measurements of skin-folds thickness. Aerobic power was assessed via a 12-minute run, anaerobic power was determined using anaerobic step test, Vertical and horizontal jump performance were evaluated with Sargent jump and standing long jump tests respectively, 40 yard dash was used to assess speed, and muscular endurance of torso and upper body were evaluated using sit-ups and push-ups tests. The sum of scores related to sport achievements was considered as the criterion evaluating success of mountain climbers. Anthropometric traits (only age and percent body fat) showed a poor positive relationship (p<0.05) with success. Whilst there were relatively strong relationship between physiological and physical traits including aerobic power (p<0.01), anaerobic power (p<0.01), vertical jump (p<0.05), lower body strength (p<0.01) and muscular endurance of torso (p<0.05) and upper body (p<0.01) with success of mountain climbers. Results indicate the importance of physiological and physical traits compared to anthropometric traits of mountain climbers and successful climbing depends largely on aforementioned characteristics.

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Physiological Responses and Evaluation of Effects of BMI, Smoking and Drinking in High Altitude Acclimatization: A Cohort Study in Chinese Han Young Males

Cited by 17 publications

References 27 publications

Obesity as a Conditioning Factor for High-Altitude Diseases

Obesity as a Conditioning Factor for High-Altitude Diseases

Noninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude

Association of anthropometric, physiologycal and physical traits to success of elite male mountain climbers

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