The physiological response can be an indicator of livestock health status related to the environment. Therefore, the purpose of this study was to determine the physiological response of dairy goats kept in Deli Serdang Regency. A total of 93 PE goats were used and their physiological responses were assessed by measuring rectal temperature, heart, and respiration rate at different ages, body weights, and pregnancy statuses. Subsequently, statistical analysis of the data obtained was carried out with T-Test using SPSS version 21.0. The results indicated that there was no significant difference (P>0.05) in goat rectal temperature (39.0, 39.0, 38.9, and 39.0, respectively). Similarly, heart and respiration rates at various ages did not show a significant difference (P>0.05). The body weights (20-29, 30-39, and 40-50kg) did not show significant differences in heart rate (P>0.05) at 72, 69.6, and 73.2 beats/minute. The physiological response of rectal temperature and respiration rate also did not show any difference (P>0.05). There was no significant difference in the respiratory rate of pregnant and nonpregnant goats (p>0.05), which were 42.9 and 42.9 breaths/minute, respectively. It was concluded that dairy goats in Tandukan Raga Village, Deli Serdang Regency did not show different physiological responses such as rectal temperature, heart and respiration rate despite differences in age, weight, and pregnancy status.