Physiological problems in patients undergoing autologous and allogeneic hematopoietic stem cell transplantation

Abstract

Objective:Stem cell transplantation is usually performed in an effort to extend the patient's life span and to improve their quality of life. This study was conducted to determine the postoperative physiological effects experienced by patients who had undergone autologous and allogeneic stem cell transplantation.Methods:The research is a descriptive study conducted with a sample of 60 patients at Stem Cell Transplantation Units in Ankara. Percentile calculation and chi-square tests were used to evaluate the data.Results:When a comparison was made between patients who had undergone allogeneic Hematopoietic stem cell transplantation (HSCT) and those who had undergone autologous HSCT, results indicated that problems occurred more often for the allogeneic HSCT patients. The problems included: Digestion (94.3%), dermatological (76.7%), cardiac and respiratory (66.7%), neurological (66.7%), eye (56.7%), infections (26.7%) and Graft Versus Host Disease (5 patients). Furthermore, the problems with pain (50%), numbness and tingling (40%), and speech disorders (3 patients) were observed more often in autologous BMT patients.Conclusion:Autologous and allogeneic patients experienced most of physical problems due to they receive high doses of chemotherapy. Therefore, it is recommended that an interdisciplinary support team approach should be usedtohelp reduce and manage the problems that may arise during patient care.

The Benefit of Exercise in Patients Who Undergo Allogeneic Hematopoietic Stem Cell Transplantation

“…In addition to possibly developing GVHD, patients who undergo allo-HSCT can experience a range of other side effects (Fig 1). These include mouth sores, nausea and vomiting, diarrhea, decreased physical function, fatigue, anxiety, dry mouth, hair loss, rashes, and breathing problems 12,13 . GVHD can manifest as acute or chronic.…”

Nutritional Support for a Child With Juvenile Myelomonocytic Leukaemia at Various Stages of Antineoplastic Therapy: A Clinical Case

“…Как было указано выше, нутритивная недостаточность часто сопутствует лечению онкологических заболеваний у детей [4,5]. Описанный клинический случай -не исключение.…”

“…Вместе с тем в настоящее время единственным эффективным способом излечения ЮММЛ является трансплантация гемопоэтических стволовых клеток с предшествующим кондиционированием (высокодозная химиотерапия непосредственно перед проведением трансплантации) [3]. Однако такое агрессивное лечение сопровождается развитием большого числа осложнений, в том числе нутритивных нарушений [4].…”

CEACAM5 has different expression patterns in gastric non-neoplastic and neoplastic lesions and cytoplasmic staining is a marker for evaluation of tumor progression in gastric adenocarcinoma

“…CEACAM5 has been revealed to be involved in both homophilic (CEA to CEA) and heterophilic (CEA binding to non-CEA molecules) interactions, also CEACAM5 is showed to be an intercellular adhesion molecule involved in cancer invasion and metastasis [28][29][30][31][32]. These reactions are completely suppressed by the Fab' fragment of an anti-CEACAM5 antibody [33][34][35].…”