Physiological parameters as a tool in the diagnosis of fibromyalgia syndrome in females: A preliminary study

Elmas, Onur; Yıldız, Sedat; Bilgin, Süleyman; Demirci, Seden; Çömlekçi, Selçuk; Koyuncuoğlu, Hasan Rıfat; Akkuş, Selami; Çolak, Ömer Halil; Köklükaya, Etem; Arslan, Evren; Ozkan, Ozhan; Bilgin, Gürkan

doi:10.1016/j.lfs.2015.12.029

Cited by 14 publications

(21 citation statements)

References 24 publications

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“…For convergence speed, accuracy and robustness, RP is considered to be the best algorithm with respect to training parameters [1]. The basic idea for using Rprop, which is a local adaptive learning algorithm, is to bypass the adverse effects.…”

Section: Discussionmentioning

confidence: 99%

“…Since it is proper with the data number, k=5 was accepted in the study. After the classification is performed, accuracy rates were calculated separately for each group according to equation (1) and the final accuracy rate was achieved by taking the average of the five-class' classification rates.…”

Section: K-fold Cross Validationmentioning

confidence: 99%

“…In order to increase the diagnosis reliability, reliable test methods and detection of a biological signal methods were to be used instead of the existing method which uses physiological tests [1].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determination of New Bio Signal and Tests Alternative to Verbal Pain Scale for Diagnosing Fibromyalgia Syndrome

Uçar

Bozkurt²,

Bozkurt³

2016

IJIGSP

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Abstract-In this study; values obtained through the analysis of blood samples, taken under laboratory conditions, from patients diagnosed with fibromyalgia syndrome and healthy subjects and the sympathetic skin response parameters were used. With the aim of classifying verbal pain scale, which is one of the psychological test scores used for fibromyalgia syndrome diagnosis; relation between the sympathetic skin response effect on other test data and the verbal pain scale were reviewed by using different conditions of available data. Within this framework, three different algorithms were used for classification with high accuracy rates. These algorithms are: Multi-Layer Feed-Forward Neural Networks, Probabilistic Neural Network and Radial Basis Function Neural Network. For Multi-Layer Feed-Forward Neural Networks classification algorithm, classification was done with three different training algorithms, Levenberg-Marquardt back propagation, Resilient back propagation and the Scaled conjugate gradient back propagation and the results were compared elaborately. Based on the results, by using all variables the following accuracy rates were obtained: 68.2% accuracy with Levenberg-Marquardt training algorithm, 77.3% accuracy with the Resilient back propagation training algorithm, and 68.18% accuracy with the Scaled conjugate gradient training algorithm. These success rates show that there is a relationship between verbal pain scale, sympathetic skin response and other test data.

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Section: Discussionmentioning

confidence: 99%

Section: K-fold Cross Validationmentioning

confidence: 99%

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Determination of New Bio Signal and Tests Alternative to Verbal Pain Scale for Diagnosing Fibromyalgia Syndrome

Uçar

Bozkurt²,

Bozkurt³

2016

IJIGSP

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“…Therefore, regarding to the role that CRP plays in fibromyalgia, it has been found elevated serum levels in FM patients compared to healthy levels in almost all studies [4,97,[130][131][132][133][134][135][136][137][138]. Only on three studies, published until now, it was not reported differences on the CRP´s concentration on FM patients and healthy individuals [139][140][141].…”

Section: Pentraxins In Fmmentioning

confidence: 99%

Altered Inflammatory Mediators in Fibromyalgia

Garcı́a¹,

Carvajal-Gil²,

Herrero-Olea³

et al. 2017

Rheumatology

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Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain, tenderness, stiffness, fatigue, and sleep and mood disturbances. Current evidences suggest that inflammatory mediators may have an important role in the pathogenesis of fibromyalgia. Every day new evidences emerging of the role of the immune system and the inflammatory process in the pathophysiology of this disease. Thus, the aim of this work has been review that altered inductors, inflammatory mediators and effectors have been reported in fibromyalgia, and its relationship to disease's symptoms. If in fibromyalgia underlies widespread disruption of most characteristic components on the inflammatorý s process (endogenous inductors, mediators and effectors) is logical to think that fibromyalgia is producing a sustained inflammatory response in time, unregulated, responsible for the disease´s symptoms. Keywords:Fibromyalgia; Inflammation; HMGB1; Age; Inflammasome; Cytokines; Chemokines; Pentraxins; Lipid mediators; Monocytes; Neutrophils FibromyalgiaFibromyalgia (FM) is a chronic disease characterized by a widespread pain, tenderness, stiffness, fatigue, and sleep and mood disturbances. The prevalence of FM in the world ranges between 0.7% and 3.2%. It is more prevalent on women than men with a ratio women/men 20:1 (4.2% prevalence on women compared with 0.2% on men) [1] and it can develop at any age [2].The exact cause of fibromyalgia is unknown, but it has been proposed that the FM is a stress-related disorder that may involve a dysfunction of the hypothalamic-pituitary-adrenal axis (HPA) [3,4]. Thus, adverse life events, such as emotional, physical and sexual abuse on children and adults have been suggested to contribute to the development of FM [5][6][7].Risk factors FM have been the subject of much debate in recent research. There is no doubt that the experience of an abusive relationship, maintained over time, is a stressful situation that could be related to the presence of FM [8,9].Like all physiological systems, the immune system is under the control of the neuro-endocrine system and interacts and works in concert with other regulatory body systems, thus immune cells respond to neuroendocrine signals through specific receptors for hormones, neurotransmitters and neuropeptides. Therefore, dysregulation of the hypothalamic-pituitary-adrenal axis by chronic stress situations necessarily lead to a dysregulation of the immune function. Thus, inflammation is a characteristic process of the immune system, considered a defense response that is induced by infection or trauma. However, inflammation may also be induced by stress and tissue dysfunction in the absence of infection, there is a close relationship between body homeostasis, stress response and inflammation, since inflammation has both a component response to stress as a component defense response. Inflammation and FibromyalgiaIn 2001, Wallace et al. [10] were the first to suggest that inflammatory mediators, such as cytokines, could play a role in fibromyalgia. Prior results...

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“…FMS"nin etiyolojisi ve patofizyolojisi henüz tam olarak bilinememektedir. Araştırmacıların bir bölümü fiziksel hastalıklar üzerine odaklanmış, diğer bir bölümü psikiyatrik sorunları ele almıştır (2)(3)(4). Daha az bir bölümü ise kalıtımsal yapıyı ve ağrı eşiği ile ilişkisini değerlendirmiştir (5).…”

Section: Introductionunclassified

The Effect of Traumatic Experiences on Disease in Patients with Fibromyalgia Syndrome

Ataoğlu

Ankaralı

Ataoğlu

et al. 2018

Konuralp Tıp Dergisi

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Kompleks ve çok boyutlu bir klinik sendrom olan Fibromiyalji sendromunda (FMS),birçok somatik ve psikolojik yakınmalar olduğu için, hastanın yaşadığı travmatik olayları; romatolojik ve psikiyatrik hastalarla karşılaştırarak, travmanın hastalığa ne kadar etkisi olduğunu araştırmak istedik. Gereç ve Yöntem: Çalışmaya 111 FMS hastası ile kontrol grubu olarak 209 osteoartrit (OA), 60 romatoid artrit (RA) ve 59 depresyonlu hasta alınmıştır. Çalışmada veri toplamak için sosyodemografik bilgi formu, Çocukluk Çağı Travma Ölçeği (ÇÇTÖ), Disosiyatif Yaşantılar Ölçeği (DYÖ), Stresle Başa Çıkma Tarzları Ölçeği (SBÇTÖ), Travmatik Yaşantılar Ölçeği (TYÖ) ve Beck Anksiyete Ölçeği (BAÖ) kullanılmıştır. Bulgular: FMS, OA, RA hastalarının ÇÇTÖ ve DYÖ puanları, depresyonlu hastalardan anlamlı derecede düşük bulunmuştur. FMS, OA, RA hastaları arasında ise anlamlı fark saptanmamıştır. FMS, OA ve RA hastalarının benzer şekilde stresle başa çıkma yollarını yoğun kullandıkları, buna karşın depresyonlu hastaların ise stresle başa çıkma yollarının tamamını daha az kullandıkları görülmüştür. TYÖ puanları açısından gruplar arasında anlamlı fark bulunmamıştır. Ancak ölçeğin her bir sorusuna verilen "evet" cevapları karşılaştırıldığında;"duygusal ihmal, vücutça istismar ve cinsel tacize uğrama"sıklığı depresyonlu hastalarda daha fazla saptanmıştır. FMS ve depresyonlu hastalarda anksiyete oranı yüksek ve benzer görülmüştür. Sonuç: Travma hem fonksiyonel hem de organik kökenli ağrılara yol açabilir. Fonksiyonel ağrıları olan FMS hastalarının travma durumları, dissosiyatif yaşantı özellikleri depresyonlu hastalardan farklı ancak organik etkenli ağrıları olan OA ve RA hastaları ile benzerdir. Travmaya bağlı stresle başa çıkma yolarını FMS, OA ve RA hastalarının sık kullandıkları, depresyonlu hastaların ise daha az kullandığı görülmektedir

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Physiological parameters as a tool in the diagnosis of fibromyalgia syndrome in females: A preliminary study

Cited by 14 publications

References 24 publications

Determination of New Bio Signal and Tests Alternative to Verbal Pain Scale for Diagnosing Fibromyalgia Syndrome

Determination of New Bio Signal and Tests Alternative to Verbal Pain Scale for Diagnosing Fibromyalgia Syndrome

Altered Inflammatory Mediators in Fibromyalgia

The Effect of Traumatic Experiences on Disease in Patients with Fibromyalgia Syndrome

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