Physiological Models Survey

Kerkhof, Peter L. M.

doi:10.1002/047134608x.w1432

Wiley Encyclopedia of Electrical and Electronics Engineering 1999

DOI: 10.1002/047134608x.w1432

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Physiological Models Survey

Peter L. M. Kerkhof

Abstract: The sections in this article are A Primer of Control Systems in Physiology Modeling in Biology Simulation in Physiology Basic Types of Neural Control Systems Fluctuations of the Membrane Potential Control of Movement and Locomotion Closed Loop Drug Delivery … Show more

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2017

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Cited by 2 publications

References 14 publications

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Monte Carlo method applied to the evaluation of the relationship between ejection fraction and its constituent components

Kerkhof

Yoo

Merillon³

et al. 2017

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Ventricular function is routinely assessed by applying the clinically accepted metric ejection fraction (EF). The numerical value of EF depends on the interplay between end-systolic volume (ESV) and end-diastolic volume (EDV). The relative impact of the two constitutive components has received little attention. Pediatric cardiologists are interested in EF vs ESV when evaluating various congenital abnormalities. Following successful surgical intervention of Fallot tetralogy, many of these patients receive follow-up, not only during childhood, but also when being adults. Cardiologists diagnosing and treating elderly patients often analyze EF vs EDV, notably for phenotyping heart failure patients. Therefore, we study EF vs ESV as well as EF vs EDV in more detail. We explore the fundamentals of EF while analyzing a Fallot patient group. Three routes were followed, namely nonlinear regression, by implementing a Monte Carlo approach to generate EDV on the basis of known ESV values, and by using a theoretical graphical derivation. Our MRI-based post Fallot repair study includes left (LV) and right ventricular (RV) data (N=124). Using a robust approach we employed nonlinear regression with ESV as an independent variable. EDV was also assessed by Monte Carlo generated values for stroke volume within a physiological range. In all cases ESV emerges as the dominant component of EF, with less (P<;0.0001) impact of EDV. Using three independent routes we demonstrate that values for EF primarily depend on the corresponding ESV. This relationship is nonlinear, and correlation is always better with ESV compared to EDV in these patients, and confirmed in random number modeling studies.

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Monte Carlo method applied to the evaluation of the relationship between ejection fraction and its constituent components

Kerkhof

Yoo

Merillon³

et al. 2017

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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H emodynamic Interventions and the Pressure-Diameter Loop of the Left Ventricle and the Proximal Aorta in the Conscious Dog

Kerkhof¹,

Li²

The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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The dynamics of the left ventricle (LV) have been extensively investigated. However, most studies refer to steady state conditions. We addressed the beat-to-beat variations resulting from hemodynamic interventions analyzed in the chronically instrumented dog. This approach permits serial studies in the same subject under physiological conditions. In particular we investigated the end-systolic pressure-dimension relationship and characteristics of the proximal aorta. The findings obtained during basal conditions, exercise and pharmacologic intervention indicate that several universal regulatory mechanisms are involved, besides various phenomena that exhibit a substantial degree of variability.

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Physiological Models Survey

Abstract: The sections in this article are A Primer of Control Systems in Physiology Modeling in Biology Simulation in Physiology Basic Types of Neural Control Systems Fluctuations of the Membrane Potential Control of Movement and Locomotion Closed Loop Drug Delivery … Show more

Cited by 2 publications

References 14 publications

Monte Carlo method applied to the evaluation of the relationship between ejection fraction and its constituent components

Monte Carlo method applied to the evaluation of the relationship between ejection fraction and its constituent components

H emodynamic Interventions and the Pressure-Diameter Loop of the Left Ventricle and the Proximal Aorta in the Conscious Dog

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