Physiological mechanism and pathogenesis of weanling diarrhea

Jejunal microflora in malnourished Gambian children.

“…This accumulation (i.e. due to net secretion) was shown by perfusion studies by James et al (1972). It is not known whether this applies to those with chronic diarrhoea and certainly there was nothing to suggest that those with acute diarrhoea in our series had a greater flow of jejunal fluid up the tube than those with chronic diarrhoea.…”

“…Discussion James, Drasar, and Miller (1972) found no correlation between the numbers or types of jejunal organisms and the nutritional state of his patients in Jamaica. Most of these had small numbers of mixed aerobic and anaerobic organisms, though 4 had a total count above 104 organisms/ml.…”

Effect of Klebsiella pneumoniae enterotoxin on intestinal transport in the rat.

“…Such is the case among most malnourished children who have chronic diarrhea (47)(48)(49)(50)(51) and abnormalities of intestinal transport and structure (52,53).…”

Gastroenteritis in London and Jamaica: a clinical and bacteriological study

“…James, Drasar & Miller (1972) found no bacteriological differences before and after the treatment of childhood malnutrition in a metabolic ward, although the recovered group they studied were different children from the group with malnutrition. Mata et al (1972b) studying the same malnourished children (without diarrhoea) before, during and after recovery from malnutrition noted significant reductions in the bacterial populations of the jejunum but not of stomach or duodenum.…”