Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus

Schvarcz, E; Palmér, Mats; Åman, Jan; Horowitz, Michael; Stridsberg, Mats; Berne, Christian

doi:10.1016/s0016-5085(97)70080-5

Cited by 372 publications

(276 citation statements)

References 3 publications

Supporting

Mentioning

252

Contrasting

Unclassified

Order By: Relevance

“…Symptoms such as anorexia, nausea, vomiting, and dyspepsia are nonspecific and resemble many other conditions (186) and may just be associated with the presence of diabetes (181). Importantly, hyperglycemia, hypoglycemia, and acute changes in blood glucose are well documented to alter gastric emptying (182,187,188), as are some medications, especially opioids, other pain management agents, and glucagon-like peptide 1 receptor agonists (189,190). Therefore, all these factors known to affect gastric emptying should always be considered before a firm diagnosis is established.…”

Section: Gastrointestinal Neuropathiesmentioning

confidence: 99%

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

et al. 2016

View full text Add to dashboard Cite

Section: Gastrointestinal Neuropathiesmentioning

confidence: 99%

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

et al. 2016

View full text Add to dashboard Cite

“…In health and diabetes, there is a complex relationship between upper gastrointestinal function and glycaemic control, such that postprandial glycaemia is both a determinant of, and determined by, gastric emptying 17,18 . Pre-prandial blood glucose concentrations influence gastric emptying in the critically ill, as is the case in diabetes 17 , while glucose absorption is reduced in these patients compared to health and is dependent on the rate of gastric emptying 19 .…”

Section: Introductionmentioning

confidence: 99%

“…Pre-prandial blood glucose concentrations influence gastric emptying in the critically ill, as is the case in diabetes 17 , while glucose absorption is reduced in these patients compared to health and is dependent on the rate of gastric emptying 19 . Glycaemic control appears to be a pivotal determinant of outcome in the critically ill, with marked hyperglycaemia and hypoglycaemia associated with adverse outcomes including increased mortality and hospital length of stay 20,21 .…”

Section: Introductionmentioning

confidence: 99%

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness

Summers

Bartolomeo

Zaknic

et al. 2014

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

“…Moreover, it has now been established that acute changes in blood glucose concentrations affect gastric emptying in patients with diabetes, that gastric emptying is slower during hyperglycemia when compared with euglycemia (14,15), and that gastric emptying is accelerated during hypoglycemia (16). Changes in the blood glucose concentrations that are within the normal postprandial range also influence gastric emptying, and the emptying of both solids and liquids is slower at a blood glucose concentration of 8 vs. 4 mmol/l in both healthy volunteers and patients with uncomplicated type 1 diabetes (17).…”

mentioning

confidence: 99%

Predictors of Delayed Gastric Emptying in Diabetes

et al. 2001

View full text Add to dashboard Cite

OBJECTIVE -To define the predictors of the rate of gastric emptying in patients with diabetes.RESEARCH DESIGN AND METHODS -A total of 101 outpatients with diabetes (79 type 1 and 22 type 2) underwent measurements of gastric emptying of a solid/liquid meal (scintigraphy), upper gastrointestinal symptoms (questionnaire), glycemic control (blood glucose concentrations during gastric emptying measurement), and autonomic nerve function (cardiovascular reflexes).RESULTS -The gastric emptying of solid and/or liquid was delayed in 66 (65%) patients. Solid (retention at 100 min 64 Ϯ 3.2 vs. 50.2 Ϯ 3.6%, P Ͻ 0.005) and liquid (retention at 100 min 22.7 Ϯ 1.7 vs. 16.0 Ϯ 1.8%, P Ͻ 0.001) gastric emptying was slower in women than in men. Of all upper gastrointestinal symptoms (including nausea and vomiting), only abdominal bloating/fullness was associated with slower gastric emptying (P Ͻ 0.005). A multiple regression analysis demonstrated that both abdominal bloating/fullness and female sex were predictors of slower gastric emptying of both solids and liquids.CONCLUSIONS -We conclude that the presence of abdominal bloating/fullness but not any other upper gastrointestinal symptom is associated with diabetic gastroparesis and that gastric emptying is slower in diabetic women than in diabetic men. Diabetes Care 24:1264 -1269, 2001T he application of radioisotopic techniques to quantify gastric emptying has established that delayed gastric emptying (gastroparesis) occurs in 30 -50% of patients with longstanding diabetes (1-9), and diabetes and functional dyspepsia represent the two most common disorders associated with chronic gastroparesis (10). Diabetic gastroparesis is also recognized to represent a clinically important problem because of its potential sequelae of upper gastrointestinal symptoms, impaired oral drug absorption, and poor control of blood glucose concentrations (1). However, determinants of the rate of gastric emptying in patients with diabetes are controversial and poorly defined (1-9). Particularly, it is uncertain whether diabetic gastroparesis can be predicted based on clinical, demographic, or biochemical variables. In patients with diabetes, there is also a relatively poor relationship between gastric emptying of solids and gastric emptying of nutrient-containing liquid-meal components (2-4,7); delayed liquid gastric emptying frequently occurs and may be associated with normal solid emptying (7). Hence, the predictors of delay in liquid emptying may potentially differ from those associated with the delayed gastric emptying of solids.Previous studies have reported a relatively weak relationship between upper gastrointestinal symptoms and the rate of gastric emptying in patients with diabetes (2-7). Accordingly, it has been suggested that gastroparesis cannot be predicted based on symptoms and that objective measurement of gastric emptying is required for diagnosis (1,8). In most of these studies, symptoms have been evaluated using either a global symptom score and/or individual upper gastrointestinal symp...

show abstract

Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus

Cited by 372 publications

References 3 publications

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness

Predictors of Delayed Gastric Emptying in Diabetes

Contact Info

Product

Resources

About