Physiological features of periodontal regeneration and approaches for periodontal tissue engineering utilizing periodontal ligament cells

Effect of SBD.4A – a defined multicomponent preparation of Angelica sinensis – in periodontal regeneration models

“…From the previous studies (Zhao et al, 2006) it was known that SBD.4A stimulates fibroblasts and angiogenesis, which are important for the periodontal ligament repair (fibroblasts), and overall periodontal healing (Benatti et al, 2007;Cochran and Wozney, 1999). First the question was addressed as to whether SBD.4A has an effect on bone-generating osteoblasts in vitro and it was found that it does stimulate osteoblast proliferation (no difference between the effect of 200 and 400 ng/mL may be due to the fact that the maximal stimulation by SBD.4A had been achieved with 200 ng/mL).…”

Tooth-derived stem cells: Update and perspectives

“…Tissue engineering is an emerging field based on basic science and engineering technology, designed to create suitable conditions to regenerate damaged tissues [75][76][77][78] . The basic components for tissue engineering involve an interactive triad of scaffolds [79][80][81] , signaling molecules [82][83][84] and cells [24,33,41,85] , which play a fundamental role in the regeneration process [24,76,86,87] .…”

The transplantation of mesenchymal stem cells derived from unconventional sources: an innovative approach to multiple sclerosis therapy

“…PDL is particularly suitable to different functions; especially, it supports the teeth in their sockets and simultaneously it cushions the mechanical stress falling on the dental elements, for example, during mastication. Furthermore, PDL contains stem cells with the potential to form periodontal structures such as cementum and ligament (Ulmer et al 2010), as well as fibroblasts, cementoblasts, osteoblasts, macrophages, undifferentiated ectomesenchymal cells, cell rests of Malassez, and vascular and neural elements that are capable of generating and preserving periodontal tissues (Benatti et al 2007).…”