Physiological Evidence for Delayed Age-related Hearing Loss in Two Long-lived Rodent Species (Peromyscus leucopus and P. californicus)

Capshaw, Grace; Vicencio-Jimenez, Sergio; Screven, Laurel A.; Burke, Kali; Weinberg, Madison M.; Lauer, Amanda M.

doi:10.1007/s10162-022-00860-4

Cited by 10 publications

(8 citation statements)

References 72 publications

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“…Neurons that encode low-frequency signals exhibit phase locking (Joris and Trussell, 2018 ; Rutherford et al, 2021 ), which plays a fundamental role in generating an output in phase with the stimulus frequency. In a natural environment, low-frequency sounds travel greater distances than high-frequency sounds (Joris and Trussell, 2018 ; Capshaw et al, 2022 ). In particular, some rodents have been observed to vocalize with low-frequency sounds in order to communicate with each other when separated by long distances (Briggs and Kalcounis-Rueppell, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Volume electron microscopy reveals age-related circuit remodeling in the auditory brainstem

Charan

Hua

Wang

et al. 2022

Front. Cell. Neurosci.

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The medial nucleus of the trapezoid body (MNTB) is an integral component of the auditory brainstem circuitry involved in sound localization. The giant presynaptic nerve terminal with multiple active zones, the calyx of Held (CH), is a hallmark of this nucleus, which mediates fast and synchronized glutamatergic synaptic transmission. To delineate how these synaptic structures adapt to reduced auditory afferents due to aging, we acquired and reconstructed circuitry-level volumes of mouse MNTB at different ages (3 weeks, 6, 18, and 24 months) using serial block-face electron microscopy. We used C57BL/6J, the most widely inbred mouse strain used for transgenic lines, which displays a type of age-related hearing loss. We found that MNTB neurons reduce in density with age. Surprisingly we observed an average of approximately 10% of poly-innervated MNTB neurons along the mouse lifespan, with prevalence in the low frequency region. Moreover, a tonotopy-dependent heterogeneity in CH morphology was observed in young but not in older mice. In conclusion, our data support the notion that age-related hearing impairments can be in part a direct consequence of several structural alterations and circuit remodeling in the brainstem.

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Section: Discussionmentioning

confidence: 99%

Volume electron microscopy reveals age-related circuit remodeling in the auditory brainstem

Charan

Hua

Wang

et al. 2022

Front. Cell. Neurosci.

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“…ABR testing procedures were similar to those previously described in this laboratory (e.g., Capshaw et al , 2022 ; Vicencio-Jimenez et al , 2021 ). Briefly, ABR testing was conducted in a sound-treated booth (Industrial Acoustics Company, Bronx, NY; 59 × 74 × 60 cm 3 ) lined with acoustic foam (Pinta Acoustic, Minneapolis, MN).…”

Section: Methodsmentioning

confidence: 99%

Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise

Mondul,

Burke,

Morley

et al. 2024

The Journal of the Acoustical Society of America

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Medial olivocochlear (MOC) efferents modulate outer hair cell motility through specialized nicotinic acetylcholine receptors to support encoding of signals in noise. Transgenic mice lacking the alpha9 subunits of these receptors (α9KOs) have normal hearing in quiet and noise, but lack classic cochlear suppression effects and show abnormal temporal, spectral, and spatial processing. Mice deficient for both the alpha9 and alpha10 receptor subunits (α9α10KOs) may exhibit more severe MOC-related phenotypes. Like α9KOs, α9α10KOs have normal auditory brainstem response (ABR) thresholds and weak MOC reflexes. Here, we further characterized auditory function in α9α10KO mice. Wild-type (WT) and α9α10KO mice had similar ABR thresholds and acoustic startle response amplitudes in quiet and noise, and similar frequency and intensity difference sensitivity. α9α10KO mice had larger ABR Wave I amplitudes than WTs in quiet and noise. Other ABR metrics of hearing-in-noise function yielded conflicting findings regarding α9α10KO susceptibility to masking effects. α9α10KO mice also had larger startle amplitudes in tone backgrounds than WTs. Overall, α9α10KO mice had grossly normal auditory function in quiet and noise, although their larger ABR amplitudes and hyperreactive startles suggest some auditory processing abnormalities. These findings contribute to the growing literature showing mixed effects of MOC dysfunction on hearing.

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“…When a response was no longer observed, threshold was determined to be the difference between the last response and the subsequent lack of response (see above for click threshold). Visual inspection has been shown to provide similar results for threshold detection compared to objective algorithms 30 in other studies using non- Mus species, 16 therefore, we used visual inspection to determine the threshold by at least two different trained observers for each measurement.…”

Section: Methodsmentioning

confidence: 99%

“…In several species of laboratory mice and rats, numerous sex differences in various aspects of the auditory system are documented. 10 Interestingly, significantly fewer consistent sex differences have been established in the auditory function of monogamous rodent models, such as California mice, which exhibit no auditory sex differences, 16 and Mongolian gerbils, where sex-based auditory differences are only observed with regard to age-related degeneration. 10 Additionally, there are conflicting reports as to the presence of auditory sex differences in guinea pigs, which exhibit variation in the presence or absence of social monogamy and/or parental care.…”

Section: Introductionmentioning

confidence: 99%

Hearing ability of prairie voles (Microtus ochrogaster)

New,

Hurd,

Alarcon

et al. 2024

The Journal of the Acoustical Society of America

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The hearing abilities of mammals are impacted by factors such as social cues, habitat, and physical characteristics. Despite being used commonly to study social behaviors, hearing of the monogamous prairie vole (Microtus ochrogaster) has never been characterized. In this study, anatomical features are measured and auditory brainstem responses (ABRs) are used to measure auditory capabilities of prairie voles, characterizing monaural and binaural hearing and hearing range. Sexually naive male and female voles were measured to characterize differences due to sex. It was found that prairie voles show a hearing range with greatest sensitivity between 8 and 32 kHz, binaural hearing across interaural time difference ranges appropriate for their head sizes. No differences are shown between the sexes in binaural hearing or hearing range (except at 1 kHz), however, female voles have increased amplitude of peripheral ABR waves I and II and longer latency of waves III and IV compared to males. The results confirm that prairie voles have a broad hearing range, binaural hearing consistent with rodents of similar size, and differences in amplitudes and thresholds of monaural physiological measures between the sexes. These data further highlight the necessity to understand sex-specific differences in neural processing that may underly variability in responses between sexes.

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Physiological Evidence for Delayed Age-related Hearing Loss in Two Long-lived Rodent Species (Peromyscus leucopus and P. californicus)

Cited by 10 publications

References 72 publications

Volume electron microscopy reveals age-related circuit remodeling in the auditory brainstem

Volume electron microscopy reveals age-related circuit remodeling in the auditory brainstem

Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise

Hearing ability of prairie voles (Microtus ochrogaster)

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