Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion

Petersson, Johan; Sánchez-Crespo, Alejandro; Rohdin, Malin; Montmerle, Stéphanie; Nyrén, Sven; Jacobsson, Hans; Larsson, Stig; Lindahl, Sten G. E.; Linnarsson, Dag; Glenny, Robb W.; Mure, Margareta

doi:10.1152/japplphysiol.00092.2003

Cited by 73 publications

(58 citation statements)

References 53 publications

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“…Compared with other methods, SPECT suffers from a lower spatial resolution, and the time required for image acquisition is longer than for some alternative methods. However, in contrast with several other methods, SPECT allows simultaneous studies of both regional blood flow and ventilation for the whole lung (45,66,71). Both regional blood flow and ventilation can be marked during normal tidal breathing; no breathing maneuver is required.…”

Section: Comparison With Other Methods Imaging Regional Blood Flow Anmentioning

confidence: 99%

“…The finite spatial resolution means that SPECT tends to underestimate the heterogeneity of the imaged process. For example, if both regional lung ventilation and perfusion are imaged, SPECT tends to underestimate the heterogeneity of the ventilation-to-perfusion ratios (66). These principles apply also to other imaging methods, but their impact depends on the spatial resolution of the method.…”

Section: Spatial Resolutionmentioning

confidence: 99%

“…The second dose of the radiotracer should be adjusted so that the majority of the imaged radioactivity originates from the second administration. A further alternative is to use two radiotracers labeled with different energies (dual-isotope imaging), which allows two processes to be marked and imaged simultaneously (45,66,71,72).…”

Section: Imaging More Than One Processmentioning

confidence: 99%

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Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Petersson

Sánchez-Crespo²,

Larsson³

et al. 2007

Journal of Applied Physiology

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118

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Petersson J, Sá nchez-Crespo A, Larsson SA, Mure M. Physiological imaging of the lung: single-photon-emission computed tomography (SPECT). J Appl Physiol 102: 468 -476, 2007. First published September 21, 2006; doi:10.1152/japplphysiol.00732.2006.-Emission tomography provides threedimensional, quantitative images of the distribution of radiotracers used to mark physiological, metabolic, or pathological processes. Quantitative single photon emission computed tomography (SPECT) requires correction for the imagedegrading effects due to photon attenuation and scatter. Phantom experiments have shown that radioactive concentrations can be assessed within some percentage of the true value when relevant corrections are applied. SPECT is widely spread, and radiotracers are available that are easy to use and comparably inexpensive. Compared with other methods, SPECT suffers from a lower spatial resolution, and the time required for image acquisition is longer than for some alternative methods. In contrast to some other methods, SPECT allows simultaneous imaging of more than one process, e.g., both regional blood flow and ventilation, for the whole lung. SPECT has been used to explore the influence of posture and clinical interventions on the spatial distribution of lung blood flow and ventilation. Lung blood flow is typically imaged using macroaggregates of albumin. Both radioactive gases and particulate aerosols labeled with radioactivity have been used for imaging of regional ventilation. However, all radiotracers are not equally suited for quantitative measurements; all have specific advantages and limitations. With SPECT, both blood flow and ventilation can be marked with radiotracers that remain fixed in the lung tissue, which allows tracer administration during conditions different from those at image registration. All SPECT methods have specific features that result from the used radiotracer, the manner in which it is administered, and how images are registered and analyzed. respiratory physiology; regional blood flow; pulmonary ventilation; pulmonary gas exchange; radionuclide imaging THE NONUNIFORM DISTRIBUTIONS of regional lung blood flow and ventilation were first demonstrated utilizing radioactive tracers (radiotracers) and external scintillation detectors that registered the distribution of radioactivity within the lung (10,14,43,93). Later the development of the gamma camera allowed twodimensional imaging of the distribution of radiotracers (58). In the mid to late 1970s, both single-photon-emission computed tomography (SPECT) and positron emission tomography (PET) were developed, offering three-dimensional images of the in vivo distribution of radioactivity. These techniques can be used to study, for example, the three-dimensional distribution of regional blood flow or regional ventilation with a high spatial resolution. In this article we will first briefly explain the principles and characteristics of the SPECT method and second review studies that exemplifies how SPECT has been used to increase our unde...

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Section: Comparison With Other Methods Imaging Regional Blood Flow Anmentioning

confidence: 99%

Section: Spatial Resolutionmentioning

confidence: 99%

Section: Imaging More Than One Processmentioning

confidence: 99%

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Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Petersson

Sánchez-Crespo²,

Larsson³

et al. 2007

Journal of Applied Physiology

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118

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“…Although this methodology is well suited to understanding respiratory disease mechanisms because of its ability to describe the distribution of V/Q ratios in the lung, it lacks the ability to spatially distinguish underlying pathologies (10) and is not readily available in clinical practice. V/Q SPECT imaging, on the other hand, is a well-established nuclear medicine technique that provides spatial information regarding the 2 core processes of respiratory gas exchange, ventilation of alveolar units and perfusion of the pulmonary capillary beds (11), and the results of this technique correlate well with those derived from MIGET (12). SPECT V/Q is commonly used in the diagnosis of pulmonary embolism but has been shown to be sensitive to early indicators of COPD in addition to being capable of identifying comorbid disease and distinguishing pathophysiologic changes (13,14).…”

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confidence: 99%

Detection of Lung Dysfunction Using Ventilation and Perfusion SPECT in a Mouse Model of Chronic Cigarette Smoke Exposure

et al. 2013

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Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality worldwide. Exposure to cigarette smoke (CS) is a major risk factor for developing this chronic airflow impairment, but the early progression of disease is not well defined or understood. Ventilation/perfusion (V/Q) SPECT provides a noninvasive assessment of lung function to further our current understanding of how CS affects the lung. Methods: BALB/c mice were imaged with V/Q SPECT and CT after 8 and 24 wk of whole-body exposure to mainstream CS. Bronchoalveolar lavage was collected and cell differentials produced to determine inflammatory patterns. Histologic lung sections were collected, and a semiautomated quantitative analysis of airspace enlargement was applied to whole histology slices. Results: Exposure to CS induced an inflammatory response that included increases in the numbers of both mononuclear cells and neutrophils. Airspace enlargement was also significantly increased at 8 wk of CS exposure and was still more pronounced at 24 wk. Ventilation and perfusion correlation at the voxel level depicted a significant decrease in matching at 8 wk of CS exposure that was also apparent after 24 wk. The standard deviation (SD) of the log(V/Q) curve, a basic measure of heterogeneity, was increased from 0.44 6 0.02 in age-matched controls to 0.62 6 0.05 with CS exposure at 24 wk, indicating an increase in V/Q mismatching between 8 and 24 wk of CS exposure. CT, however, was not capable of discriminating control from CS-exposed animals at either time point, even with greater resolution and respiratory gating. Conclusion: This study demonstrated that, before CT detection of structural changes, V/Q imaging detected changes in gas-exchange potential. This functional impairment corresponded to increased lung inflammation and increased airspace enlargement. In vivo V/Q imaging can detect early changes to the lung caused by CS exposure and thus provides a noninvasive method of longitudinally studying lung dysfunction in preclinical models. In the future, these measures could be applied clinically to study and diagnose the early stages of chronic obstructive pulmonary disease.

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“…Different imaging modalities are currently used clinically for pulmonary ventilation evaluation. Nuclear medicine modalities, including nuclear scintigraphy, 2 , 3 single photon emission computed tomography (SPECT), 4 , 5 and positron emission tomography (PET), 6 , 7 are most commonly used. Magnetic resonance imaging (MRI) 8 , 9 and computed tomography (CT) 10 , 11 are also capable of pulmonary functional imaging.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the ΔV 4D CT ventilation calculation method usingin vivoxenon CT ventilation data and comparison to other methods

Zhang

Latifi

et al. 2016

J Applied Clin Med Phys

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Ventilation distribution calculation using 4D CT has shown promising potential in several clinical applications. This study evaluated the direct geometric ventilation calculation method, namely the ΔV method, with xenon‐enhanced CT (XeCT) ventilation data from four sheep, and compared it with two other published methods, the Jacobian and the Hounsfield unit (HU) methods. Spearman correlation coefficient (SCC) and Dice similarity coefficient (DSC) were used for the evaluation and comparison. The average SCC with one standard deviation was 0.44±0.13 with a range between 0.29 and 0.61 between the XeCT and DLV ventilation distributions. The average DSC value for lower 30% ventilation volumes between the XeCT and ΔV ventilation distributions was 0.55±0.07 with a range between 0.48 and 0.63. Ventilation difference introduced by deformable image registration errors improved with smoothing. In conclusion, ventilation distributions generated using ΔV‐4D CT and deformable image registration are in reasonably agreement with the in vivo XeCT measured ventilation distribution.PACS number(s): 87.57.N‐, 87.57.nj, 87.57.Q‐, 87.85.Pq

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Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion

Cited by 73 publications

References 53 publications

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Detection of Lung Dysfunction Using Ventilation and Perfusion SPECT in a Mouse Model of Chronic Cigarette Smoke Exposure

Evaluation of the ΔV 4D CT ventilation calculation method usingin vivoxenon CT ventilation data and comparison to other methods

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