Physiological estrogen levels are dispensable for the sex difference in immune responses during allergen-induced airway inflammation

Barrett, Aidan; Humeniuk, Piotr; Drevinge, Christina; Corciulo, Carmen; Weidner, Julie; Rådinger, Madeleine; Carlsten, Hans; Scheffler, Julia M.; Islander, Ulrika

doi:10.1016/j.imbio.2023.152360

Cited by 6 publications

(4 citation statements)

References 40 publications

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“…The authors found that HDM challenge caused elevated numbers of lung eosinophils, macrophages, and dendritic cells and caused an increase in Th17 cells in the lung and mediastinal lymph nodes only in female mice. However, treatment of ovariectomized mice with physiological levels of estradiol did not influence any of the analyzed cell populations, suggesting that female mice exert more potent innate and adaptive immune responses to HDM challenge, but these effects are not mediated by physiological levels of estradiol [ 129 ]. Sex-related differences in immune responses to HDM challenge have been also evaluated in adult mice of two different strains.…”

Section: Metabolomics In Asthmamentioning

confidence: 99%

Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics

Barosova,

Baranovicova,

Hanusrichterova

et al. 2023

IJMS

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Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in the pathophysiological changes and/or clinical features but also in their response to the treatment. Therefore, precise diagnostics represent a fundamental condition for effective therapy. In the diagnostic process, metabolomic approaches have been increasingly used, providing detailed information on the metabolic alterations associated with human asthma. Further information is brought by metabolomic analysis of samples obtained from animal models. This article summarizes the current knowledge on metabolomic changes in human and animal studies of asthma and reveals that alterations in lipid metabolism, amino acid metabolism, purine metabolism, glycolysis and the tricarboxylic acid cycle found in the animal studies resemble, to a large extent, the changes found in human patients with asthma. The findings indicate that, despite the limitations of animal modeling in asthma, pre-clinical testing and metabolomic analysis of animal samples may, together with metabolomic analysis of human samples, contribute to a novel way of personalized treatment of asthma patients.

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Section: Metabolomics In Asthmamentioning

confidence: 99%

Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics

Barosova,

Baranovicova,

Hanusrichterova

et al. 2023

IJMS

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“…And adolescence is when these changes take place. 31 Furthermore, other researchers discovered that the presence of female sex hormones in vivo was vital for enhancing Th17 cell development in vitro. 32 Moreover, female mice had considerably greater amounts of eosinophils in bronchoalveolar lavage fluid (BALF) in comparison with males in an ovalbumin (OVA)-induced asthma model, and ovariectomy has been demonstrated to reduce the level of eosinophils in BALF when compared to sham-operated controls after OVA challenge.…”

Section: Definition Of Relevant Conceptsmentioning

confidence: 99%

Section: Definition Of Relevant Conceptsmentioning

confidence: 99%

“…32 Moreover, female mice had considerably greater amounts of eosinophils in bronchoalveolar lavage fluid (BALF) in comparison with males in an ovalbumin (OVA)-induced asthma model, and ovariectomy has been demonstrated to reduce the level of eosinophils in BALF when compared to sham-operated controls after OVA challenge. 31 Severe therapy-resistant asthma Despite efforts to address modifiable factors, such as improving adherence to high-dose ICS and reducing exposure to allergens, the symptoms of STRA often remain poorly controlled in children.…”

Section: Definition Of Relevant Conceptsmentioning

confidence: 99%

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Progress in diagnosis and treatment of difficult-to-treat asthma in children

Zhou,

Zhang,

Tan

et al. 2023

Ther Adv Respir Dis

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At present, medications containing inhaled corticosteroids (ICS-containing) are the keystones of asthma treatment. The majority of asthmatic children can significantly improve clinical outcomes with little worsening by standardized inhaled glucocorticoid treatment, but there is still a small proportion of children who are unable to achieve good symptom control even after the maximum standardized treatment, known as ‘children with difficult-to-treat asthma (DA)’. The high heterogeneity of DA makes therapy challenging and expensive, which poses a serious risk to children’s health and makes it extremely difficult for clinical physicians to accurately identify and treat children with DA. This article reviews the definition, evaluation, and treatment of this asthma in order to provide a reference for optimal clinical decision-making.

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Impact of gold nanoparticles (AuNPs) on eosinophils isolated from male and female individuals

Vanharen,

Girard

2023

Immunobiology

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Physiological estrogen levels are dispensable for the sex difference in immune responses during allergen-induced airway inflammation

Cited by 6 publications

References 40 publications

Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics

Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics

Progress in diagnosis and treatment of difficult-to-treat asthma in children

Impact of gold nanoparticles (AuNPs) on eosinophils isolated from male and female individuals

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