Physiological effects of increased tissue pressure

Matsen, F A; King, Racheal V.; Krugmire, Richard B.; Mowery, Carol A.; Roche, T.

doi:10.1007/bf00265718

Cited by 35 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They may suggest that muscle blood flow can be limited by the effect of increased intramuscular pressure at rest after exercise. The findings of the present study are also consistent with previous studies in which increased intramuscular pressure impairs muscle blood flow at rest (Clayton et al, 1977; Matsen et al, 1979), and a significant decrease or even cessation of blood flow when tissue pressure exceeded 30 to 60 mmHg and perfusion pressure fell below 30 mmHg (Ashton, 1975; Sheridan & Matsen, 1975; Clayton et al, 1977; Zhang et al, 2001b).…”

Section: Discussionsupporting

confidence: 92%

Abnormally elevated intramuscular pressure impairs muscle blood flow at rest after exercise

Zhang

Styf

2004

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

We used photoplethysmography (PPG) to measure the relative changes in the anterior tibial muscle blood flow (MBF) in response to exercise when intramuscular pressure (IMP) was elevated (the test leg) or when IMP was normal (the control leg). The elevated IMP was induced by applying venous obstruction of 40 mmHg or 65 mmHg (thigh tourniquet) of a casted leg in eight healthy subjects. Subjects performed dorsiflexion of both feet in sitting position with or without venous obstruction. IMP at rest after exercise increased to 39.4±7.9 mmHg or to 58.3±8.4 mmHg, respectively. MBF at rest before exercise was 100%. At rest after exercise, it increased to 184±52.6% in the test leg when IMP was 39.4 mmHg, and to 279±108.3% in the control leg. MBF at rest after exercise was 156±58.2% in the test leg when IMP was 58.3 mmHg and 303±95.3% in the control leg. The abnormally elevated IMP induced by venous obstruction of a casted leg reduced MBF at rest after exercise. PPG seems to be a suitable method to measure changes in MBF in response to exercise and in experimental conditions with abnormally elevated IMP.

show abstract

Section: Discussionsupporting

confidence: 92%

Abnormally elevated intramuscular pressure impairs muscle blood flow at rest after exercise

Zhang

Styf

2004

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

show abstract

“…However, the combination of early and severe motor deficit and no pain, either spontaneous or evoked by passive movements of the feet, is unusual and not easy to interpret. Several experiments have been conducted to assess the effects of the intracompartmental raised pressure on neuromuscular function [24,25,26,27,28]. The outcome is a gradual impairment of the anterior compartment structures of which the nerve is the most sensitive, especially in its terminal segment [22,23,24].…”

Section: Discussionmentioning

confidence: 99%

Exercise-induced bilateral anterior tibial compartment syndrome without pain

et al. 1986

View full text Add to dashboard Cite

We report the case of a 41 year old man who complained of a severe bilateral deficit of the anterior tibial compartment two hours after prolonged exercise. On admission there was no spontaneous or evoked pain, no objective sensory deficit but total loss of dorsiflexion of feet and toes. Electrophysiological investigation showed no voluntary or evoked electrical activity in tibial and extensor digitorum muscles; while peroneus longus and gastrocnemius muscles showed a near-normal pattern. On the other hand a weak motor response was obtained by direct stimulation of the anterior tibial muscle belly. An early bilateral fasciotomy was followed by almost complete recovery of the spontaneous and evoked motor activities of the tibial anterior muscles. On the basis of these findings we discuss the possible pathogenetic role of a neuroapraxic block of the deep peroneal nerve where it crosses the anterior fibular septum and supply a possible interpretation of the absence of pain.

show abstract

“…This could be due to the short duration of each condition (5-10 min), as oxygenation changes are slower compared with blood flow changes. For example, when known external pressures were applied for 5 h to hindlimbs of rabbits, muscle blood flow and tissue oxygenation were compromised (34). However, the magnitude of change is small compared with any ischemic condition (Fig.…”

Section: Tibial Oxygenation Response To Lbnpmentioning

confidence: 99%

Lower-body negative pressure restores leg bone microvascular flow to supine levels during head-down tilt

Siamwala

Lee

Macias

et al. 2015

Journal of Applied Physiology

View full text Add to dashboard Cite

Siamwala JH, Lee PC, Macias BR, Hargens AR. Lower-body negative pressure restores leg bone microvascular flow to supine levels during head-down tilt. J Appl Physiol 119: 101-109, 2015. First published April 30, 2015 doi:10.1152/japplphysiol.00028.2015.-Skeletal unloading and cephalic fluid shifts in microgravity may alter the bone microvascular flow and may be associated with the 1-2% bone loss per month during spaceflight. The purpose of this study was to determine if lower-body negative pressure (LBNP) can prevent microgravity-induced alterations of tibial microvascular flow. Headdown tilt (HDT) simulates the cephalad fluid shift and microvascular flow responses that may occur in microgravity. We hypothesized that LBNP prevents HDT-induced increases in tibial microvascular flow. Tibial bone microvascular flow, oxygenation, and calf circumference were measured during 5 min sitting, 5 min supine, 5 min 15°HDT, and 10 min 15°HDT with 25 mmHg LBNP using photoplethysmography (PPG), near-infrared spectroscopy (NIRS), and strain-gauge plethysmography (SGP). Measurements were made simultaneously. DT position, tibial microvascular flow returned to supine levels (1.1 Ϯ 0.5 V; RMANOVA P Ͻ 0.001). Tibial oxygenation did not change significantly during sitting, supine, HDT, or HDT with LBNP. However, calf circumference decreased with 5 min 15°HDT (Ϫ0.7 Ϯ 0.4 V; RMANOVA P Ͻ 0.0001) from supine (Ϫ0.5 Ϯ 0.4 V). However, with LBNP calf circumference returned to supine levels (Ϫ0.4 Ϯ 0.1 V; RMANOVA P ϭ 0.002). These data establish that simulated microgravity increases tibial microvascular flow and LBNP prevents these increases. The results suggest that LBNP may provide a suitable countermeasure to normalize the bone microvascular flow during spaceflight. bone microvascular flow; head-down tilt; spaceflight; photoplethysmography; oxygenation; limb girth PROLONGED SPACEFLIGHT results in the loss of cancellous and cortical bone of tibia at the rate of 1-

show abstract

Physiological effects of increased tissue pressure

Cited by 35 publications

References 25 publications

Abnormally elevated intramuscular pressure impairs muscle blood flow at rest after exercise

Abnormally elevated intramuscular pressure impairs muscle blood flow at rest after exercise

Exercise-induced bilateral anterior tibial compartment syndrome without pain

Lower-body negative pressure restores leg bone microvascular flow to supine levels during head-down tilt

Contact Info

Product

Resources

About