Physiological Disposition of a New Diuretic, 14C-Metolazone, in Dogs

Cohen, A.; Hartman, Arthur D.; Hinsvark, O. N.; Kraus, P.; Zazulak, W.

doi:10.1002/jps.2600620615

Cited by 10 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the results obtained a mechanism for the oxidation of MT in pH 7 0.1 M phosphate buffer is proposed (Scheme 2), which is in agreement with the MT data obtained using other methodologies [3,11,20,21]. The first step, peak 1 a , is assigned to the oxidation of the nitrogen in the sulfonamide moiety and involves the transfer of two electrons and two protons.…”

Section: Square-wave Voltammetrysupporting

confidence: 83%

Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode

2008

View full text Add to dashboard Cite

Metolazone is a diuretic agent used in patients with edematous states and/or hypertension. The electrochemical behavior of metolazone on a glassy carbon electrode was investigated using cyclic, differential pulse, and square-wave voltammetry at different pHs. The pH dependent oxidation of metolazone occurs in two consecutive steps in a diffusion-controlled mechanism and involves the formation of a main oxidation product. The first oxidation process is reversible, and involves two electrons and two protons corresponding to the oxidation of nitrogen in the sulfonamide moiety. The second oxidation process is irreversible, also occurs in the sulfonamide moiety, involves a one electrontransfer, and is followed by deprotonation to produce a cation radical, which reacts with water and yields a hydroxylated product. The diffusion coefficient of metolazone was calculated to be 3.43 Â 10 À6 cm 2 s À1 in pH 7.0 0.1 M phosphate buffer.

show abstract

Section: Square-wave Voltammetrysupporting

confidence: 83%

Electrochemical Oxidation of Metolazone at a Glassy Carbon Electrode

2008

View full text Add to dashboard Cite

show abstract

“…57 Withdrawal of thiazides is associated with rapid volume expansion, weight gain and a fall in renin, but blood pressure rises slowly, demonstrating a temporal dissociation between the diuretic and blood pressure lowering effects of thiazides. 52,57 The slow offset of the hypotensive effect of thiazides is not understood.Thiazides, and the thiazide-like agents, chlorthalidone, metolazone and indapamide, bind to plasma proteins, including albumin, and red blood cells (probably as a result of their affinity for carbonic anhydrase), [58][59][60][61][62] although there is no current evidence that this accumulation has functional significance.…”

Section: Haemodynamic Effects Of Thiazidesmentioning

confidence: 99%

How do thiazide and thiazide-like diuretics lower blood pressure?

Hughes

2004

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

“…12 SampIes were prepared for counting HC as described by Cohen and associates. 3 Activity was measured in a Packed Tri-Carb, Model 3320, with efnciency corrected by channels ratio with reference to appropriate quench curves.…”

mentioning

confidence: 99%