Physiological Changes Induced by Long Term Administration of Saccharin Compared with Aspartame to Male Albino Rats

Histopathological Effects of Sodium Saccharin Toxicity on Liver and Kidney of Rats in Duhok City-Iraq

“…These are disagreements with this current research, while Alkafafy et al, (2015) showed in their study that sodium saccharin may provoke stress on the hepatic cells due to oxidation via decreasing the activity of the catalase enzyme and declining the concentration of total antioxidants in plasma [23].It was confirmed that saccharin destructively influences both liver and kidney sections and changes biochemical markers, either at high or low doses, in rats [24]. The findings of this research are also in line with those of [13][14][15][16][17][18][19][20][21][22][23][24][25], who showed that the administration of 10 mg/kg of animal weight and an elevated dose of 500 mg/kg body weight of saccharin revealed a major raise in the serum markers of liver function as well as the activity of liver enzymes like ALT, AST, and ALP. This modification was recommended as an ordinary sign of liver damage, so the lesions that appeared in the liver might be due to a lower antioxidant concentration in plasma, which is caused by saccharin and then elevates the free radical level, which interacts with cellular membranes, or could lead to hepatic parenchymal damage as well as result in aminotransferase activity [26].…”

“…In addition, saccharin is not absorbed or metabolized throughout the human and animal digestive systems, so it is excreted through the kidney without any changes. Depending on this cause, the FDA judged that saccharin is not dangerous [11][12][13][14][15][16][17][18][19][20][21][22]. These are disagreements with this current research, while Alkafafy et al, (2015) showed in their study that sodium saccharin may provoke stress on the hepatic cells due to oxidation via decreasing the activity of the catalase enzyme and declining the concentration of total antioxidants in plasma [23].It was confirmed that saccharin destructively influences both liver and kidney sections and changes biochemical markers, either at high or low doses, in rats [24].…”

“…In addition, saccharin may lead to eczema and urticaria in several citizens. Due to the avid concentration of saccharin in the placenta, it is limited to consumption in pregnant women [16]. The majority of studies concluded that long-term use of saccharin is the main reason for hepatic and kidney toxicity; therefore, the purpose of this study was to verify the pathological lesions induced by variant doses of sodium saccharin administration on the kidney and liver.…”

Comparative effect of Aspartame and Sodium Cyclamate on Lipid Profile, Histology and Biochemical Parameters of Kidney and Liver Function in Albino Rats

“…The findings is in line with the result obtained by Helal et al, [9] who reported increased in ALT and AST levels in rats administered acesulfame-k and aspartame. Similarly, Abdallah, [19] reported increase in serum ALT, AST and ALP activities in rats administered low and high dose of saccharin. AST and ALT are important determinant for liver dysfunction and damage since damaged cells release cytosolic enzymes into the blood [20] .…”

Impact of Long Term Cyclamate and Saccharin Consumption on Biochemical Parameters in Healthy Individuals and Type 2 Diabetes Mellitus Patients

“…Catalase and SOD activities were inhibited, as well as the glutathione activity, which prevented the cell death by the toxic radicals. [14] Signi cant elevation of serum creatinine and urea concentrations with both high and low doses of saccharin also have been reported previously [14,15] The compounds most commonly used on the market today as substitutes for common sugar in diet drinks and food products are saccharin, aspartame and cyclamate. Many fears have arisen around the associated side effects of consuming arti cial sweeteners in addition to broader concerns about their safety for human consumption.…”