Physiological cell death in endocrine‐dependent tissues: an ovarian perspective

Martimbeau, Stephanie; Tilly, Jonathan L.

doi:10.1046/j.1365-2265.1997.00157.x

Cited by 34 publications

(26 citation statements)

References 104 publications

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“…It has been postulated that FSH stimulates granulosa cells to secrete IGF-1, which in turn signals thecal cells to produce EGF and TGFα, thereby exerting an antiapoptotic response . In contrast, expression of TGFβ in hormone-deprived follicles may promote apoptosis (Martimbeau and Tilly 1997). Other pro-and antiapoptotic genes have been shown to affect follicular atresia.…”

Section: Ovarymentioning

confidence: 99%

“…Unlike the male reproductive tissues, however, cyclic endocrine-dependent cell death in these female tissues is a normal physiological process closely linked to the cyclic fluctuations in hormonal secretions (Martimbeau and Tilly 1997). The phases of the female ovarian and menstrual cycles closely correlate with alterations in hormonal levels (Gosden and Spears 1997;Kiess and Gallaher 1998;Martimbeau and Tilly 1997) (Fig.…”

Section: Endocrine Regulation Of Involution In the Ovary And Uterusmentioning

confidence: 99%

“…Here, we will focus on the influence of the endocrine system in maintaining tissue homeostasis in a healthy adult human being. Continuous tissue renewal by balancing cell division and cell deletion is mediated by circulating levels of specific hormones (Kiess and Gallaher 1998;Martimbeau and Tilly 1997;Tenniswood et al 1992;Thompson 1994). Additionally, hormonal availability also determines the expression of growth factors and cytokines, which modulate cell turnover in target tissues.…”

Section: Introductionmentioning

confidence: 99%

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Hormonal regulation of physiological cell turnover and apoptosis

Medh

Thompson

2000

Cell Tissue Res

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Physiological cell turnover plays an important role in maintaining normal tissue function and architecture. This is achieved by the dynamic balance of cellular regeneration and elimination, occurring periodically in tissues such as the uterus and mammary gland, or at constant rates in tissues such as the gastrointestinal tract and adipose tissue. Apoptosis has been identified as the prevalent mode of physiological cell loss in most tissues. Cell turnover is precisely regulated by the interplay of various endocrine and paracrine factors, which modulate tissue and cell-specific responses on proliferation and apoptosis, either directly, or by altering expression and function of key cell proliferative and/or death genes. Although recent studies have provided significant information on specific tissue systems, a clearly defined pathway that mediates cell turnover has not yet emerged for any tissue. Several similarities exist among the various tissues with regard to the intermediates that regulate tissue homeostasis, enabling a better understanding of the general mechanisms involved in the process. Here we review the mechanisms by which hormonal and cytokine factors mediate cell turnover in various tissues, emphasizing common themes and tissue-specific differences.

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Section: Ovarymentioning

confidence: 99%

Section: Endocrine Regulation Of Involution In the Ovary And Uterusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hormonal regulation of physiological cell turnover and apoptosis

Medh

Thompson

2000

Cell Tissue Res

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“…Using sensitive biochemical and molecular biological analyses, the occurrence of apoptosis in female germ cells, follicular granulosa cells, and luteal cells during ovarian development and cyclic function in laboratory and domestic animal species has been established (reviewed in Tilly, 1996;Martimbeau and Tilly, 1997). Moreover, identification of apoptosis as the underlying mechanism responsible for controlled cellular deletion in the ovary has sparked numerous investigations into the intracellular effector pathways that are either activated or repressed during execution of the cell death command.…”

Section: Introductionmentioning

confidence: 99%

Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary

et al. 1998

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Recent data support a role for apoptosis, under tight regulatory control by bcl-2, oxidative stress response, tumor suppressor, and CASP gene family members, in mediating granulosa cell demise during follicular atresia in the rodent and avian ovary. Herein we evaluated the occurrence of apoptosis in the human and baboon ovary relative to follicular health status, and analyzed expression of several cell death genes in these tissues.

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“…For GO 0015975 (energy deriva- March 2017, pp.64-79, © 2017 tion by oxidation of reduced inorganic compounds), endocrine diseases are related to oxidation of compounds (Olmez-Hanci et al, 2009). GO 0043067 (regulation of programmed cell death) regulates programmed cell death which affects endocrine-dependent tissues (Martimbeau and Tilly, 1997). GO 0031589 (cell-substrate adhesion) attaches a cell to the underlying substrate via adhesion molecules.…”

Section: Feature Analysismentioning

confidence: 99%

Biological Feature Selection and Disease Gene Identification using New Stepwise Random Forests

Hwang¹

2017

Industrial Engineering and Management Systems

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Identifying disease genes from human genome is a critical task in biomedical research. Important biological features to distinguish the disease genes from the non-disease genes have been mainly selected based on traditional feature selection approaches. However, the traditional feature selection approaches unnecessarily consider many unimportant biological features. As a result, although some of the existing classification techniques have been applied to disease gene identification, the prediction performance was not satisfactory. A small set of the most important biological features can enhance the accuracy of disease gene identification, as well as provide potentially useful knowledge for biologists or clinicians, who can further investigate the selected biological features as well as the potential disease genes. In this paper, we propose a new stepwise random forests (SRF) approach for biological feature selection and disease gene identification. The SRF approach consists of two stages. In the first stage, only important biological features are iteratively selected in a forward selection manner based on one-dimensional random forest regression, where the updated residual vector is considered as the current response vector. We can then determine a small set of important biological features. In the second stage, random forests classification with regard to the selected biological features is applied to identify disease genes. Our extensive experiments show that the proposed SRF approach outperforms the existing feature selection and classification techniques in terms of biological feature selection and disease gene identification.

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Physiological cell death in endocrine‐dependent tissues: an ovarian perspective

Cited by 34 publications

References 104 publications

Hormonal regulation of physiological cell turnover and apoptosis

Hormonal regulation of physiological cell turnover and apoptosis

Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary

Biological Feature Selection and Disease Gene Identification using New Stepwise Random Forests

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