Physiological Basis of Vagotomy

Ad, Beattie

doi:10.1136/bmj.1.4605.607

Cited by 9 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The intrinsic motility does differ from that seen in the abomasum (Duncan, 1953), omasum (Bueno & Rucksbusch, 1974) and human stomach (Grimson et al 1947, Beattie, 1949 in that it takes 1-2 weeks following vagotomy to become fully established. It seems likely that some reorganization within the myenteric plexus may take place during this period.…”

Section: Discussionmentioning

confidence: 86%

“…It is well known that the major contractions of the reticulo-rumen are controlled via the vagus nerves from gastric centres in the medulla oblongata (Mangold & Klein, 1927;Hoflund, 1940;Duncan, 1953;Bell & Lawn, 1955;Iggo, 1956;Andersson, P. C. GREGOR Y Kitchell & Persson, 1959;Beghelli, Borgatti & Parmeggiani, 1963;Howard, 1968; Harding & Leek, 1971), and that removal ofthis vagal control results in reticulo-rumen paralysis. This response contrasts markedly with that of the monogastric stomach of man (Grimson, Baylin, Taylor, Hesser & Rundles, 1947; Beattie, 1949) or dog (McCrea, McSwiney & Stopford, 1926) and with that of the abomasum, the ruminant counterpart ofthe monogastric stomach (Duncan, 1953), which all retain considerable activity after vagotomy although often with considerably modified emptying rates.…”

Section: Introductionmentioning

confidence: 76%

See 1 more Smart Citation

Forestomach motility in the chronically vagotomized sheep

Gregory¹

1982

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The motility of the reticulo-rumen and omasum in conscious sheep was studied by electromyography from chronically implanted nichrome wire electrodes. The sheep were subjected to vagotomy and were maintained totally by intragastric infusion of liquid nutrients before and after vagotomy. Before vagotomy the motility of the forestomach was essentially similar to that seen in roughage-fed sheep.2. Bilateral thoracic vagotomy transiently abolished all electrical activity of the reticulo-rumen and omasum, but within 1 day some activity returned. Frequent periods of rhythmic local small group discharges were seen over the reticulo-rumen, while the omasum showed prolonged (1-5 min) bursts of mainly slow wave activity.3. Within 1-2 weeks of vagotomy strong contractions of the reticulo-rumen were visible by radiography. Electromyographically, they comprised a rhythmic series of some two to five large group discharges recurring approximately once a minute. Each series of activity was separated from the next by a short period of quiescence. The discharges occurred almost simultaneously over the whole reticulo-rumen and so contrasted with the progressive forward or backward spread of activity seen in the intact animal. The bursts of activity in the omasum, lasting 05--2 min, were not co-ordinated with the activity of the reticulo-rumen as they are in the intact animal.4. The activity in the reticulo-rumen and omasum was not affected by bilateral section of the splanchnic nerves and removal of the coeliaco-mesenteric ganglia. Reticulo-rumen but not omasal activity was abolished by atropine (0-1 mg/kg) or hexamethonium (2 mg/kg), while both were stimulated by pentagastrin (3 jug/kg).5. Following vagotomy reticulo-rumen motility was no longer influenced by feeding, or by tactile stimulation of the buccal cavity or oesophagus. Severe distension of the abomasum caused a slight acceleration of the motility rhythm compared to the inhibition seen before vagotomy.6. It is concluded that the reticulo-rumen motility observed after vagotomy is an intrinsic cholinergic motility which is dependent upon the activity of the myenteric plexus. The motility ofthe omasum after vagotomy is similar to that seen in the intact animal and differs from that of the rumen in that it appears not to depend wholly upon cholinergic control.

show abstract

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 76%

Forestomach motility in the chronically vagotomized sheep

Gregory¹

1982

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…In 1950 Beattie reported a series of 164 cases of chronic duodenal ulcer treated by vagotomy and pylorectomy with two deaths and the remainder in excellent health. He stated (Beattie 1949): “There is little doubt that vagotomy will ultimately come to be accepted as the routine surgical treatment for chronic duodenal ulcer…. It may even find a place in the treatment of some varieties of chronic gastric ulcer.”…”

Section: Results Of Vagotomy and Pyloroplastymentioning

confidence: 99%

Vagotomy and Pyloroplasty in the treatment of Peptic Ulcer

Qvist¹

1965

Int J Clinical Practice

View full text Add to dashboard Cite

show abstract

“…The A-contractions were inhibited by distension of the canal or proximal region of C3, and either stimulated or inhibited by distension of the distal region of C3 or the hind stomach. In sheep primary reticulorumen contractions are inhibited by distension of the omasal canal (Bueno, 1975) or fundic region of the abomasum (Harding & Leek, 1972) and may be stimulated or inhibited by distension of the pyloric antrum of the abomasum (Phillipson, 1939;Titchen, 1958). Thus, forestomach emptying in both sheep and llama may be regulated according to the conditions in the more aboral stomach compartments.…”

Section: Discussionmentioning

confidence: 99%

“…It would seem therefore that the complex sequence of contractions causing mixing and emptying of a large organ like the reticulorumen or C 1 and C2 of the llama requires absolute central neural control, including central motor supply. In the more posterior stomach compartments, or the stomach of monogastric animals such as man (Beattie, 1949) or dog (McCrea, McSwiney & Stopford, 1926) it seems sufficient for the vagus nerves to regulate an intrinsic motility. The observation that adrenaline had an inhibitory effect on all stomach compartments suggests that the sympathetic nerves could also be involved in inhibitory control of motility, as seen in ruminants (Titchen, 1958), e.g.…”

Section: Discussionmentioning

confidence: 99%

CONTROL OF STOMACH MOTILITY IN THE LLAMA (LAMA GUANACOE F. GLAMA)

Gregory¹,

Heller²,

Engelhardt³

1985

Exp Physiol

View full text Add to dashboard Cite

SUMMARYManometric and electromyographic recordings of stomach motility were made in five conscious llamas to investigate the influence of distension of the stomach compartments, of temporary cervical vagal blockade and the influence of atropine, acetylcholine and adrenaline. The frequency of A-contractions was slowed by distension of the canal joining compartment 2 (C2) and compartment 3 (C3), or of the proximal region of C3, and either increased and/or reduced by distension of the distal region of C3 or the hind stomach. The number of B-contractions in a cycle was increased according to the degree of distension of the cranial sac of compartment 1 (C 1). B-contractions were also induced by distension of the canal or proximal region of C3 and were inhibited by distension of the distal region of C3 or the hind stomach. Contractions of C3 were not influenced by distension of Cl or C2 but were inhibited by distension of the canal, while distension within C3 caused a local excitation and an inhibition both proximal and distal to the point of stimulation. The hind stomach was only affected by local stimuli. Temporary vagal blockade abolished all contractions of C1, C2, the canal and C3, but had little effect on the motility of the hind stomach. Infusion of atropine (0-01 mg/kg), acetylcholine (7-33 1zg/kg. min) and adrenaline (0 3 Itg/kg. min) inhibited motility in all stomach compartments except the hind stomach where acetylcholine was stimulatory. it is concluded that while the hind stomach may have intrinsic motility, the contractions of Cl, C2, the canal and C3 of the llama stomach are dependent upon a vagal motor nerve supply and that the pattern of contractions observed is regulated at least partially according to the individual degree of distension of each of the stomach compartments.

show abstract

Physiological Basis of Vagotomy

Cited by 9 publications

References 7 publications

Forestomach motility in the chronically vagotomized sheep

Forestomach motility in the chronically vagotomized sheep

Vagotomy and Pyloroplasty in the treatment of Peptic Ulcer

CONTROL OF STOMACH MOTILITY IN THE LLAMA (LAMA GUANACOE F. GLAMA)

Contact Info

Product

Resources

About