Physiological basis of obesity treatment by percutaneous vagus nerve stimulation

Kiselev, Anton R.; Shvartz, Elena; Джиоева, О. Н.; Drapkina, О. М.

doi:10.17116/profmed202225101111

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…Current knowledge of the vagus nerve anatomy in conjunction with evidence from basic experimental and clinical research has contributed to the fact that vagus nerve stimulation (VNS) is now actively investigated as a potential therapy for a number of conditions, including epilepsy [1][2][3], depression [4,5], migraine [6], tinnitus [7], heart failure [8][9][10], and other diseases [11][12][13][14]. There are two main methods of VNS: invasive and noninvasive (transcutaneous).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability

Shvartz,

Sizhazhev,

Sokolskaya

et al. 2023

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Many previous studies have demonstrated that transcutaneous vagus nerve stimulation (VNS) has the potential to exhibit therapeutic effects similar to its invasive counterpart. An objective assessment of VNS requires a reliable biomarker of successful vagal activation. Although many potential biomarkers have been proposed, most studies have focused on heart rate variability (HRV). Despite the physiological rationale for HRV as a biomarker for assessing vagal stimulation, data on its effects on HRV are equivocal. To further advance this field, future studies investigating VNS should contain adequate methodological specifics that make it possible to compare the results between studies, to replicate studies, and to enhance the safety of study participants. This article describes the design and methodology of a randomized study evaluating the effect of short-term noninvasive stimulation of the auricular branch of the vagus nerve on parameters of HRV. Primary records of rhythmograms of all the subjects, as well as a dataset with clinical, instrumental, and laboratory data of all the current study subjects are in the public domain for possible secondary analysis to all interested researchers. The physiological interpretation of the obtained data is not considered in the article.

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Section: Discussionmentioning

confidence: 99%

The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability

Shvartz,

Sizhazhev,

Sokolskaya

et al. 2023

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“…Researchers concluded that potential health risks in obese individuals were to a greater extent associated with autonomic dysfunction [5]. A variety of pathogenetic processes linking autonomic dysfunction to obesity have launched the development of methods for excess body weight correction via affecting the mechanisms of autonomic regulation (e.g., by stimulating the vagus nerve) [7].…”

Section: Introductionmentioning

confidence: 99%

Indices Of Heart Rate Variability Are Not Associated With Obesity In Patients 30-60 Years Of Age Without Chronic Noncommunicable Diseases

Olga N.,

Rogozhkina,

Shvartz

et al. 2023

Russ Open Med J

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Objective –– to compare heart rate variability (HRV) in patients aged 30-60 years without chronic noncommunicable diseases (CNCDs) with and without obesity. Methods –– The groups of obese (n=43) and nonobese (n=28) patients without CNCDs ranged 30 through 60 years of age. We assessed the conventional HRV indices according to the clinical guidelines, as well as the synchronization index (S) for low-frequency (LF) oscillations evaluated from HRV and photoplethysmogram (PPG). Results –– No statistically significant differences in HRV indices and S index were detected between the study groups. Conclusion –– HRV indices and synchronization of LF oscillations detected from HRV and PPG were not significantly associated with obesity in patients aged 30-60 years without CNCDs.

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Physiological basis of obesity treatment by percutaneous vagus nerve stimulation

Cited by 2 publications

References 56 publications

The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability

The Effect of Short-Term Transcutaneous Electrical Stimulation of Auricular Vagus Nerve on Parameters of Heart Rate Variability

Indices Of Heart Rate Variability Are Not Associated With Obesity In Patients 30-60 Years Of Age Without Chronic Noncommunicable Diseases

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