Physiological assessment of in vivo human knee articular cartilage using sodium MR imaging at 1.5T

Hani, Ahmad Fadzil M.; Kumar, Dileep; Malik, Aamir Saeed; Razak, Ruslan

doi:10.1016/j.mri.2013.01.007

Cited by 13 publications

(5 citation statements)

References 15 publications

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“…Overall sodium MRI has limited clinical applicability as it requires dedicated coils and has limited SNR. Although researchers have performed imaging at 1.5T, most studies have been performed at 3T or higher field strength and focused on imaging of cartilage repair tissue and osteoarthritis. While sodium MRI has shown great promise, further hardware and software improvements are necessary to complete the translation of sodium MRI into a clinically feasible method for 3T systems .…”

Section: Compositional Imaging Techniques To Measure Cartilagementioning

confidence: 99%

Prestructural cartilage assessment using MRI

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Neumann

2016

Magnetic Resonance Imaging

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Cartilage loss is irreversible, and to date, no effective pharmacotherapies are available to protect or regenerate cartilage. Quantitative prestructural/compositional MR imaging techniques have been developed to characterize the cartilage matrix quality at a stage where abnormal findings are early and potentially reversible, allowing intervention to halt disease progression. The goal of this article is to critically review currently available technologies, present the basic concept behind these techniques, but also to investigate their suitability as imaging biomarkers including their validity, reproducibility, risk prediction and monitoring of therapy. Moreover, we highlighted important clinical applications. This review article focuses on the currently most relevant and clinically applicable technologies, such as T2 mapping, T2*, T1ρ, delayed gadolinium enhanced MRI of cartilage (dGEMRIC), sodium imaging and glycosaminoglycan chemical exchange saturation transfer (gagCEST). To date, most information is available for T2 and T1ρ mapping. dGEMRIC has also been used in multiple clinical studies, although it requires Gd contrast administration. Sodium imaging and gagCEST are promising technologies but are dependent on high field strength and sophisticated software and hardware. Level of Evidence: 5 J. Magn. Reson. Imaging 2017;45:949–965

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Section: Compositional Imaging Techniques To Measure Cartilagementioning

confidence: 99%

Prestructural cartilage assessment using MRI

Link

Neumann

2016

Magnetic Resonance Imaging

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“…), though the role of sodium imaging in clinical application remains to be more firmly established. One recent study was able to acquire sodium images of knee articular cartilage for assessing OA at 1.5T with an image quality reportedly acceptable to be in use in a clinical practice for quantitative assessment of cartilage degeneration . Further research on reproducibility and clinical correlations of this method remain to be performed.…”

Section: Radiographymentioning

confidence: 99%

Morphologic and quantitative magnetic resonance imaging of knee articular cartilage for the assessment of post‐traumatic osteoarthritis

Eagle

Potter

Koff

2016

Journal Orthopaedic Research

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Orthopedic trauma, such as anterior cruciate ligament (ACL) disruption, is a common source of osteoarthritis in the knee. Magnetic resonance imaging (MRI) is a non-invasive multi-planar imaging modality commonly used to evaluate hard and soft tissues of diarthrodial joints following traumatic injury. The contrast provided by generated images enables the evaluation of bone marrow lesions as well as delamination and degeneration of articular cartilage. We will provide background information about MRI signal generation and decay (T and T values), the utility of morphologic MRI, and the quantitative MRI techniques of T , T , and T * mapping, to evaluate subjects with traumatic knee injuries, such as ACL rupture. Additionally, we will provide information regarding the dGEMRIC, sodium, and gagCEST imaging techniques. Finally, the description and utility of newer post hoc analysis techniques, such as texture analysis, will be given. Continued development and refinement of these advanced MRI techniques will facilitate their clinical translation. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:412-423, 2017.

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“…The common GAG chain components found in cartilage are chondroitin sulfate and keratin sulfate. These long chains of negatively charged glycosaminoglycan attract cations such as sodium; therefore, sodium concentration in cartilage is found to be higher than surrounding fluid and sodium MRI provides quantitative assessment of cartilage loss in patients with osteoarthritis 6,7,8, 16,28,36 . The fixed charge density (FCD) derived from sodium MRI using ideal Donnan equilibrium has shown to be strongly correlated with FCD derived from GAG assays in natural cartilage 35 .…”

Section: Fcd Calculation From Sodium Mri Data and Gag Assaymentioning

confidence: 99%

“…Using sodium triple-quantum coherence NMR, it has been shown that engineered cartilage tissues are less anisotropic in vitro 24 . Sodium ions binds with negatively charged proteoglycans in the cartilage tissue, therefore sodium MRI has been used to assess cartilage integrity and to quantify proteoglycan loss in the case of osteoarthritis extensively 6,7,8,16,28,36 . However, the use of sodium MRI for the evaluation of proteoglycans in tissue-engineered cartilage has not been established yet.…”

Section: Introductionmentioning

confidence: 99%

High Field Sodium MRI Assessment of Stem Cell Chondrogenesis in a Tissue-Engineered Matrix

et al. 2015

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The development of non-invasive assessment techniques in vitro and in vivo is essential for monitoring and evaluating the growth of engineered cartilage tissues. Magnetic resonance imaging (MRI) is the leading non-invasive imaging modality used for assessing engineered cartilage. Typical MRI uses water proton relaxation times (T1 and T2) and apparent diffusion coefficient (ADC) to assess tissue growth. These techniques, while excellent in providing the first assurance of tissue growth, are unspecific to monitor the progress of engineered cartilage extracellular matrix components. In the current article, we present high field (11.7 T, (1)H freq. = 500 MHz) sodium MRI assessment of tissue-engineered cartilage at the early stage of tissue growth in vitro. We observed the chondrogenesis of human bone marrow derived stromal cells seeded in a gradient polymer-hydrogel matrix made out of poly(85 lactide-co-15 glycolide)--PuraMatrix™ for 4 weeks. We calculated the sodium concentration in the engineered constructs using a model of sodium MRI voxels that takes into account scaffold volume, cell density and amount of glycosaminoglycan (GAG). The sodium concentration was then converted to the fixed charge density (FCD) and compared with FCD derived from biochemical GAG analysis. Despite the small amount of GAG present in the engineered constructs, the sodium MRI derived FCD is found to be correlated (Pearson correlation coefficient R = 0.79) with the FCD derived from biochemical analysis. We conclude that sodium MRI could prove to be an invaluable tool in assessing engineered cartilage quantitatively during the repair or regeneration of cartilage defects.

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Physiological assessment of in vivo human knee articular cartilage using sodium MR imaging at 1.5T

Cited by 13 publications

References 15 publications

Prestructural cartilage assessment using MRI

Prestructural cartilage assessment using MRI

Morphologic and quantitative magnetic resonance imaging of knee articular cartilage for the assessment of post‐traumatic osteoarthritis

High Field Sodium MRI Assessment of Stem Cell Chondrogenesis in a Tissue-Engineered Matrix

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