Physiological antioxidative/oxidative status in bovine colostrum and mature milk

Marta, Kankofer; Lipko-Przybylska, Justyna

doi:10.2298/avb0803231k

Cited by 15 publications

(2 citation statements)

References 22 publications

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“…Apart from Ig, colostrum also provides antioxidants [ 26 ], defence cells (including macrophages), lipids and proteins that are sensitive to oxidation and contribute to the function of various antibacterial systems. However, colostrum itself is a source of oxidation-reduction reactions [ 27 ] and the Ig contained therein are molecules with high susceptibility to peroxidation [ 28 ]. As it was found in calves, the redox balance of the colostrum is closely associated with the IgG absorption [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Melatonin Administration in Pregnant Ewes with Growth, Redox Status and Immunity of Their Offspring

Bouroutzika

Ciliberti

Caroprese

et al. 2021

Animals

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In this study, the effects of melatonin treatment on growth, redox status and immunity in prenatally stressed newborn lambs were evaluated. Thirty-seven newborn lambs were allocated into two groups (melatonin-MEL and control-CON), based on whether their mothers were treated with melatonin implants or not, respectively. All pregnant ewes were exposed to heat stress. The body weight of lambs was recorded at birth (L0), and then on days 15 (L15) and 40 (L40). Redox biomarkers [total antioxidant capacity (TAC), glutathione (GSH), thiobarbituric acid reactive substances (TBARS)] were assayed in blood samples collected from lambs on days L0, L1, L2, L5, L10 and L40. Chemical analysis and antioxidant capacity were evaluated in colostrum and milk samples collected at the same time points with blood samples. Cytokines (IL-1β, IL-6, IL-10, IFN-γ) and immunoglobulin (IgG) were assayed in blood and colostrum samples collected from ewes on days L0 and L1, and in lambs’ blood on days L0, L1 and L2. The results revealed that body weight gain of newborn lambs did not differ between the two groups (p > 0.05). Better redox status was found in MEL lambs until L2, as well as higher antioxidant capacity in the colostrum of MEL ewes compared to CON ones on day L0 (p < 0.05). In MEL ewes’ colostrum, higher protein content was measured on day L0 and higher fat content on L1 compared to CON group (p < 0.05). The highest level of IL-6 was found in MEL ewes on L1, with a concomitant increase of IL-10 level in MEL lambs in comparison to CON lambs on L2. Moreover, CON colostrum resulted in a higher level of IL-10 within time, coupled with an increased level of IgG found in lambs’ plasma on L2 (p = 0.04). This study indicated that melatonin could be administered as antioxidant and immune-modulatory regime in prenatally stressed offspring in order to cope with the crucial first days of their life. This effect of melatonin was also amplified by crosstalk between IL-6, IL-10 and IgG production, resulting in an improved quality of produced milk.

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Section: Introductionmentioning

confidence: 99%

Association of Melatonin Administration in Pregnant Ewes with Growth, Redox Status and Immunity of Their Offspring

Bouroutzika

Ciliberti

Caroprese

et al. 2021

Animals

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“…Data obtained from the cow colostrum and the milk showed dynamic changes in total antioxidant capacity (TAC) within 7 days postpartum [9]. Albera and Kankofer [10] compared the activity of lactoperoxidase, lactoferrin, and ceruloplasmin between cows and sows.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant defence of colostrum and milk in consecutive lactations in sows

Lipko-Przybylska

Kankofer

2012

Ir Vet J

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BackgroundParturition is supposed to be related to oxidative stress, not only for the mother, but also for the newborn. Moreover, it is not clear whether consecutive pregnancies, parturitions, and lactations are similar to each other in regards to intensity of metabolic processes or differ from each other. The aim of the study was to compare dynamic changes of antioxidative parameters in colostrum and milk of sows taken during 72 h postpartum from animals in consecutive lactations. Activities of glutathione peroxidase (GSH-Px), glutathione transferase (GSH-Tr), and superoxide dismutase (SOD), and amount of vitamin A and C were measured. Healthy pregnant animals were divided into 4 groups according to the assessed lactation: A -1st lactation (n = 10), B - 2nd and 3rd lactation (n = 7), C - 4th and 5th lactation (n = 11), D - 6th - 8th lactation (n = 8). The colostrum was sampled immediately after parturition and after 6, 12, 18 and 36 h while the milk was assessed at 72 h after parturition. Spectrophotometric methods were used for measurements.ResultsThe activity of antioxidative enzymes and the concentration of vitamin A increased with time postpartum. The concentration of vitamin C was the highest between the 18th and 36th h postpartum.ConclusionsDynamic changes in the values of antioxidant parameters measured during the study showed that sows milk provides the highest concentration of antioxidants in the 2nd and 3rd and 4th and 5th lactation giving the best defence against reactive oxygen species to newborns and mammary glands.

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Effect of colostrum redox balance on the oxidative status of calves during the first 3 months of life and the relationship with passive immune acquisition

Abuelo

Pérez-Santos

Hernández

et al. 2014

The Veterinary Journal

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Physiological antioxidative/oxidative status in bovine colostrum and mature milk

Cited by 15 publications

References 22 publications

Association of Melatonin Administration in Pregnant Ewes with Growth, Redox Status and Immunity of Their Offspring

Association of Melatonin Administration in Pregnant Ewes with Growth, Redox Status and Immunity of Their Offspring

Antioxidant defence of colostrum and milk in consecutive lactations in sows

Effect of colostrum redox balance on the oxidative status of calves during the first 3 months of life and the relationship with passive immune acquisition

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