Physiological and Pathophysiological Role of Large-Conductance Calcium-Activated Potassium Channels (BKCa) in HUVECs and Placenta

Neira, Fernanda; Neira, Nataly; Torres, Jimena; González-Ortiz, Marcelo

doi:10.1007/978-3-031-32554-0_3

Cited by 2 publications

(3 citation statements)

References 59 publications

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“…Their activity has been shown to be involved in numerous physiological or pathological processes. These include membrane excitability, Ca 2+ signaling, hormone or neurotransmitter release, stimulus-secretion coupling, muscle relaxation, and motor coordination [1,[3][4][5][6][7][8][9][10]. However, the specific roles and levels of abundance can vary between tissues and under different physiological or pathological conditions.…”

Section: Physiological Implications Of Large-conductance Ca 2+ -Activ...mentioning

confidence: 99%

“…It is worth noting, however, that a mitochondrial BK Ca channel has been previously identified in dermal fibroblasts and heart cells [15,18,19]. These channels are located within the inner mitochondrial membrane, where they contribute to the regulation of mitochondrial function and cellular bioenergetics [10,20].…”

Section: The Role Of Bk Ca Channel Activity Residing In Cardiac Fibro...mentioning

confidence: 99%

“…BKCa channel activity has been observed to contribute to membrane hyperpolarization in vascular endothelial cells, as part of endothelium-derived processes [10,20]. It is important to note that, unlike vascular smooth muscle cells, where the BK Ca channels employ a negative feedback mechanism to regulate the excessive increase of intracellular Ca 2+ ions, in vascular endothelial cells, the functioning of BK Ca channels in vascular endothelial cells relies on positive feedback mechanisms to control the intracellular elevation of Ca 2+ ions.…”

Section: The Role Of Bk Ca Channel Activity Residing In Cardiac Fibro...mentioning

confidence: 99%

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Exploring the Impact of BKCa Channel Function in Cellular Membranes on Cardiac Electrical Activity

Chen,

Shih,

et al. 2024

IJMS

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This review paper delves into the current body of evidence, offering a thorough analysis of the impact of large-conductance Ca2+-activated K+ (BKCa or BK) channels on the electrical dynamics of the heart. Alterations in the activity of BKCa channels, responsible for the generation of the overall magnitude of Ca2+-activated K+ current at the whole-cell level, occur through allosteric mechanisms. The collaborative interplay between membrane depolarization and heightened intracellular Ca2+ ion concentrations collectively contribute to the activation of BKCa channels. Although fully developed mammalian cardiac cells do not exhibit functional expression of these ion channels, evidence suggests their presence in cardiac fibroblasts that surround and potentially establish close connections with neighboring cardiac cells. When cardiac cells form close associations with fibroblasts, the high single-ion conductance of these channels, approximately ranging from 150 to 250 pS, can result in the random depolarization of the adjacent cardiac cell membranes. While cardiac fibroblasts are typically electrically non-excitable, their prevalence within heart tissue increases, particularly in the context of aging myocardial infarction or atrial fibrillation. This augmented presence of BKCa channels’ conductance holds the potential to amplify the excitability of cardiac cell membranes through effective electrical coupling between fibroblasts and cardiomyocytes. In this scenario, this heightened excitability may contribute to the onset of cardiac arrhythmias. Moreover, it is worth noting that the substances influencing the activity of these BKCa channels might influence cardiac electrical activity as well. Taken together, the BKCa channel activity residing in cardiac fibroblasts may contribute to cardiac electrical function occurring in vivo.

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Section: Physiological Implications Of Large-conductance Ca 2+ -Activ...mentioning

confidence: 99%

Section: The Role Of Bk Ca Channel Activity Residing In Cardiac Fibro...mentioning

confidence: 99%

Section: The Role Of Bk Ca Channel Activity Residing In Cardiac Fibro...mentioning

confidence: 99%

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Exploring the Impact of BKCa Channel Function in Cellular Membranes on Cardiac Electrical Activity

Chen,

Shih,

et al. 2024

IJMS

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Preeclampsia and transport of ions and small molecules: a literature review

Moura,

Nunes,

Crestani

et al. 2024

Placenta

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Physiological and Pathophysiological Role of Large-Conductance Calcium-Activated Potassium Channels (BKCa) in HUVECs and Placenta

Cited by 2 publications

References 59 publications

Exploring the Impact of BKCa Channel Function in Cellular Membranes on Cardiac Electrical Activity

Exploring the Impact of BKCa Channel Function in Cellular Membranes on Cardiac Electrical Activity

Preeclampsia and transport of ions and small molecules: a literature review

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