Physiological and pathological effects of phase separation in the central nervous system
Jiaxin Wang,
Hongrui Zhu,
Ruijia Tian
et al.
Abstract:Phase separation, also known as biomolecule condensate, participates in physiological processes such as transcriptional regulation, signal transduction, gene expression, and DNA damage repair by creating a membrane-free compartment. Phase separation is primarily caused by the interaction of multivalent non-covalent bonds between proteins and/or nucleic acids. The strength of molecular multivalent interaction can be modified by component concentration, the potential of hydrogen, posttranslational modification, … Show more
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