Physiological and Pathological Consequences of Vascular BMP Signaling

Promoting angiogenesis and diabetic wound healing through delivery of protein transduction domain-BMP2 formulated nanoparticles with hydrogel

“…13 BMP2 also induces in vitro proliferation of human pulmonary artery and aortic ECs, increases migratory efficiency, and promotes tube formation in human dermal microvascular ECs, as well as human aortic and umbilical vein ECs. 13,15,[18][19][20][21] The angiogenic potential of BMP2 led us to hypothesize that it could improve diabetic wound healing. However, few studies have explored the association between BMP2 and wound healing.…”

“…6,7,9 Recombinant human bone morphogenetic protein-2 (rhBMP2) has received Food and Drug Administration (FDA) approval for bone regeneration. 11,12 Moreover, numerous studies have demonstrated the critical role of BMP2 in physiological development and vascular homeostasis, 13 including angiogenesis. [14][15][16] BMP signaling regulates mesoderm formation, vasculogenesis, sprouting angiogenesis, arteriovenous differentiation, endothelial barrier function, and endothelial-to-mesenchymal transition.…”

“…13 During sprouting angiogenesis, BMP signaling promotes vascular morphogenesis by controlling vascular activation and maturation. 13 BMP2 also induces in vitro proliferation of human pulmonary artery and aortic ECs, increases migratory efficiency, and promotes tube formation in human dermal microvascular ECs, as well as human aortic and umbilical vein ECs. 13,15,[18][19][20][21] The angiogenic potential of BMP2 led us to hypothesize that it could improve diabetic wound healing.…”

“… 14 – 16 BMP signaling regulates mesoderm formation, vasculogenesis, sprouting angiogenesis, arteriovenous differentiation, endothelial barrier function, and endothelial-to-mesenchymal transition. 13 , 17 Furthermore, BMP signaling influences endothelial cell (EC) migration, proliferation, and network formation. 13 During sprouting angiogenesis, BMP signaling promotes vascular morphogenesis by controlling vascular activation and maturation.…”

“… 13 , 17 Furthermore, BMP signaling influences endothelial cell (EC) migration, proliferation, and network formation. 13 During sprouting angiogenesis, BMP signaling promotes vascular morphogenesis by controlling vascular activation and maturation. 13 BMP2 also induces in vitro proliferation of human pulmonary artery and aortic ECs, increases migratory efficiency, and promotes tube formation in human dermal microvascular ECs, as well as human aortic and umbilical vein ECs.…”